Opportunity Information: Apply for EPA G2010 STAR C1
Apply for EPA G2010 STAR C1
- The Environmental Protection Agency in the environment sector is offering a public funding opportunity titled "Computational Toxicology Biologically Based Multi Scale Modeling" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.509 Science To Achieve Results (STAR) Research Program.
- This funding opportunity was created on Apr 15, 2010 and posted on Apr 15, 2010.
- Applicants must submit their applications by Jul 15, 2010 Please refer to the full announcement, including Section IV for additional information on submission methods and due dates.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) State governments City or township governments County governments Public and State controlled institutions of higher education.
- See Section III of the announcement for additional eligibility information.
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Opportunity Summary:
The Environmental Protection Agency (EPA), through its Science to Achieve Results (STAR) Research Program, offered this funding opportunity to push forward computational toxicology research focused on biologically based, multi-scale modeling. The central aim is to support projects that build quantitative dose-response models capable of connecting environmental exposures (chemical, biological, or other environmental agents) to specific toxicity pathways, while explicitly linking effects across different levels of biological organization. In practice, this means the EPA is looking for modeling approaches that can bridge what happens at the molecular or cellular level to outcomes observed in tissues, organs, whole organisms, or even populations, so that researchers and risk assessors can better understand how exposures translate into harmful effects and at what doses those effects emerge.
A second major emphasis of the solicitation is the data foundation behind these models. Beyond building models, applicants are asked to address how model-related data can be organized, curated, managed, and shared so it becomes easier for the broader research and risk assessment communities to access, interpret, reuse, and compare. This reflects a practical goal: multi-scale computational toxicology depends heavily on diverse datasets (for example, high-throughput screening results, omics data, in vitro assay outputs, animal study data, and exposure or toxicokinetic information), and the EPA is signaling that the value of new models increases substantially if the supporting data and assumptions are transparent and usable by others.
Administratively, the opportunity is listed as a discretionary EPA funding program using grants and cooperative agreements as the funding instruments. The funding opportunity number is EPA G2010 STAR C1, and the title is "Computational Toxicology Biologically Based Multi Scale Modeling." The total estimated funding available was $3,000,000, with an anticipated four awards, implying projects of meaningful scope but limited in number. The maximum award amount (ceiling) was $750,000, and there was no cost-sharing or matching requirement, which typically lowers the barrier for academic and public-interest research teams to compete.
Eligibility was broad and included private institutions of higher education as well as public and state-controlled colleges and universities. It also allowed applications from various government entities, including state governments, counties, and city or township governments, along with federally recognized Native American tribal governments. The announcement notes that additional eligibility details are provided in Section III of the full solicitation, so applicants would need to confirm any specific conditions, limitations, or partnership requirements described there.
Key dates show that the announcement was posted and created on April 15, 2010, with an original and current closing date of July 15, 2010, and an archive date of August 14, 2010. The program is associated with CFDA number 66.509 (STAR Research Program). For submission procedures and exact due-date instructions, the announcement directs applicants to consult Section IV of the full announcement. For technical issues accessing the full announcement, the listed contact was Pasky Pascual at 202-343-9710.
Frequently Asked Questions (FAQs)
What is this EPA funding opportunity?
This is an Environmental Protection Agency (EPA) Science to Achieve Results (STAR) Research Program funding opportunity titled "Computational Toxicology Biologically Based Multi Scale Modeling."
What is the funding opportunity number?
The funding opportunity number is EPA G2010 STAR C1.
Which EPA program is sponsoring this solicitation?
The solicitation is offered through the EPA STAR Research Program.
What is the main research focus of this opportunity?
The central focus is computational toxicology research that advances biologically based, multi-scale modeling, especially quantitative dose-response models that link environmental exposures to specific toxicity pathways across multiple biological levels.
What does "biologically based, multi-scale modeling" mean in this context?
In this solicitation, it refers to modeling approaches that explicitly connect effects across different levels of biological organization, such as linking molecular or cellular events to outcomes in tissues, organs, whole organisms, or even populations.
What kinds of models is EPA looking to support?
EPA is looking to support quantitative dose-response models that can connect exposures (to chemical, biological, or other environmental agents) to defined toxicity pathways, while bridging impacts from lower-level biological mechanisms up to higher-level adverse outcomes.
What types of environmental exposures are included?
The opportunity references environmental exposures broadly, including chemical, biological, or other environmental agents.
Why is dose-response modeling emphasized?
The solicitation emphasizes dose-response modeling to help researchers and risk assessors understand how exposures translate into harmful effects and at what doses those effects emerge.
Is the opportunity only about building models?
No. A major emphasis is also placed on the data foundation behind the models, including how model-related data are organized, curated, managed, and shared for broader access and reuse.
What data-related expectations are mentioned?
Applicants are asked to address how model-related data can be organized, curated, managed, and shared so that other researchers and risk assessors can access, interpret, reuse, and compare the information more easily.
Why does EPA emphasize data organization and sharing?
The solicitation notes that multi-scale computational toxicology relies on diverse datasets, and that new models become more valuable when supporting data and assumptions are transparent and usable by others.
What kinds of datasets are relevant to this solicitation?
Examples mentioned include high-throughput screening results, omics data, in vitro assay outputs, animal study data, and exposure or toxicokinetic information.
What funding instruments are used for this opportunity?
The opportunity is described as a discretionary EPA funding program using grants and cooperative agreements as the funding instruments.
How much total funding was estimated to be available?
The total estimated funding available was $3,000,000.
How many awards were anticipated?
The solicitation anticipated four awards.
What is the maximum award amount?
The maximum award amount (ceiling) was $750,000.
Is cost-sharing or matching required?
No. The announcement states there was no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility includes private institutions of higher education and public or state-controlled colleges and universities, as well as several government entity types such as state governments, counties, city or township governments, and federally recognized Native American tribal governments.
Are there additional eligibility conditions beyond the summary?
Yes. The announcement notes that additional eligibility details are provided in Section III of the full solicitation, so applicants should confirm any specific conditions or limitations there.
When was the opportunity posted?
The announcement was posted (and created) on April 15, 2010.
What was the application deadline?
The original and current closing date listed is July 15, 2010.
When was the opportunity archived?
The archive date is August 14, 2010.
What is the CFDA number associated with this program?
The program is associated with CFDA number 66.509 (STAR Research Program).
Where are the submission procedures and due-date instructions provided?
The announcement directs applicants to consult Section IV of the full announcement for submission procedures and exact due-date instructions.
Who should be contacted for technical issues accessing the full announcement?
For technical issues accessing the full announcement, the listed contact is Pasky Pascual at 202-343-9710.
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