Opportunity Information: Apply for EPA G2010 STAR C2
Apply for EPA G2010 STAR C2
- The Environmental Protection Agency in the environment sector is offering a public funding opportunity titled "Computational Toxicology Biologically Based Multi Scale Modeling" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.509 Science To Achieve Results (STAR) Research Program.
- This funding opportunity was created on Apr 15, 2010 and posted on Apr 15, 2010.
- Applicants must submit their applications by Jul 15, 2010 Please refer to the full announcement, including Section IV for additional information on submission methods and due dates.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Native American tribal governments (Federally recognized) Private institutions of higher education State governments County governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments.
- See Section III of the announcement for additional eligibility information.
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Opportunity Summary:
The EPA Science to Achieve Results (STAR) grant opportunity titled "Computational Toxicology Biologically Based Multi Scale Modeling" (Funding Opportunity Number EPA G2010 STAR C2) supports research that improves how scientists predict and explain toxic effects from environmental exposures using modern computational and quantitative approaches. The core focus is on building biologically based, quantitative dose-response models that connect an environmental agent (such as a chemical or pollutant) to toxicity pathways and resulting health or biological outcomes across multiple levels of biology. In practical terms, the agency is looking for projects that can link what happens at smaller scales like molecular interactions and cellular pathway perturbations to higher-level outcomes such as tissue responses, organ function changes, and organism-level toxicity, with models that are quantitatively grounded rather than purely descriptive.
A second major emphasis of the solicitation is data stewardship and usability. Alongside model development, applicants are encouraged to address how the underlying data that feed these models can be organized, managed, standardized, and shared so that other researchers and risk assessors can access them more easily and use them with less friction. This reflects a broader goal of making computational toxicology outputs more reproducible and more readily translated into regulatory and risk assessment contexts, where transparency, interpretability, and data provenance matter. Projects that consider not only the scientific modeling questions but also the practical infrastructure for data interpretation, integration, and community reuse are aligned with the intent of the announcement.
The award mechanism allows funding through either cooperative agreements or grants, and the program falls under the Environmental funding activity category within CFDA 66.509 (Science To Achieve Results (STAR) Research Program). The EPA anticipated making about four awards under this announcement, with an estimated total funding amount of $3,000,000. The maximum award size listed is $750,000, and there is no cost sharing or matching requirement, which can reduce barriers for eligible applicants that may not have discretionary funds to contribute.
Eligibility is broad across government and academic sectors, including federally recognized Native American tribal governments, state governments, county governments, and city or township governments, as well as public and state-controlled institutions of higher education and private institutions of higher education. The announcement also notes that additional types of applicants may be eligible depending on the specific criteria in the full notice, with further eligibility details referenced in Section III of the official announcement.
Key administrative dates associated with the opportunity include a posted and creation date of April 15, 2010, and an application closing date of July 15, 2010, with the archive date listed as August 14, 2010. Applicants were directed to consult the full announcement, especially Section IV, for submission methods and precise due date instructions. For technical problems accessing the complete announcement, the listed contact was Pasky Pascual at 202-343-9710.
FAQs: EPA STAR Grant - Computational Toxicology Biologically Based Multi Scale Modeling (EPA G2010 STAR C2)
What is this funding opportunity?
This is an EPA Science to Achieve Results (STAR) grant opportunity titled "Computational Toxicology Biologically Based Multi Scale Modeling" (Funding Opportunity Number EPA G2010 STAR C2). It supports research aimed at improving how toxic effects from environmental exposures are predicted and explained using modern computational and quantitative methods.
What is the main scientific focus of the solicitation?
The core focus is building biologically based, quantitative dose-response models that connect an environmental agent (for example, a chemical or pollutant) to toxicity pathways and resulting health or biological outcomes across multiple levels of biology.
What does "biologically based, quantitative dose-response" mean in the context of this announcement?
Based on the description provided, it means models should be grounded in biology and provide quantitative relationships between exposure (dose) and response (effect), rather than remaining purely descriptive. The intent is to connect mechanistic biological understanding with measurable outcomes.
What does "multi-scale modeling" refer to here?
It refers to linking processes across biological scales: smaller-scale events such as molecular interactions and cellular pathway perturbations should be connected to higher-level outcomes such as tissue responses, organ function changes, and organism-level toxicity.
What kinds of environmental agents are in scope?
The opportunity describes environmental agents such as chemicals or pollutants. The key requirement is that the work connects an environmental exposure to toxicity pathways and outcomes through quantitative modeling.
What types of outcomes should the models be able to connect?
The models are expected to connect low-level biological events (molecular and cellular pathway changes) to higher-level outcomes (tissue responses, organ function changes, and organism-level toxicity), with quantitative grounding across these levels.
Is the EPA only looking for model development?
No. A second major emphasis is data stewardship and usability. Applicants are encouraged not only to develop models but also to address how the underlying data can be organized, managed, standardized, and shared to support easier access and reuse by other researchers and risk assessors.
What is meant by "data stewardship and usability" in this opportunity?
It means considering practical approaches for organizing, managing, standardizing, and sharing the data used by or produced for the models so others can access and use them with less friction. This aligns with goals of reproducibility, transparency, interpretability, and clear data provenance.
Why does the announcement emphasize sharing and standardizing data?
The description indicates this emphasis reflects a broader goal of making computational toxicology outputs more reproducible and more readily translated into regulatory and risk assessment settings, where transparency, interpretability, and data provenance are important.
How many awards did the EPA expect to make?
The EPA anticipated making about four awards under this announcement.
What is the estimated total funding amount for this opportunity?
The estimated total funding amount is $3,000,000.
What is the maximum award size?
The maximum award size listed is $750,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What funding mechanisms are available?
The award mechanism allows funding through either cooperative agreements or grants.
Which program and CFDA number is this opportunity associated with?
This opportunity falls under the Environmental funding activity category within CFDA 66.509, the Science To Achieve Results (STAR) Research Program.
Who is eligible to apply?
Eligibility is described as broad across government and academic sectors, including federally recognized Native American tribal governments, state governments, county governments, city or township governments, public and state-controlled institutions of higher education, and private institutions of higher education.
Are any other applicant types eligible?
The announcement notes that additional types of applicants may be eligible depending on the specific criteria in the full notice. It points applicants to Section III of the official announcement for further eligibility details.
When was the opportunity posted?
The posted and creation date listed is April 15, 2010.
What was the application closing date?
The application closing date is listed as July 15, 2010.
When was the opportunity archived?
The archive date is listed as August 14, 2010.
Where should applicants look for submission methods and exact due date instructions?
Applicants were directed to consult the full announcement, especially Section IV, for submission methods and precise due date instructions.
Who should be contacted for technical problems accessing the complete announcement?
For technical problems accessing the complete announcement, the listed contact was Pasky Pascual at 202-343-9710.
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