Opportunity Information: Apply for EPA G2010 STAR C3
Apply for EPA G2010 STAR C3
- The Environmental Protection Agency in the environment sector is offering a public funding opportunity titled "Computational Toxicology Biologically Based Multi Scale Modeling" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.509 Science To Achieve Results (STAR) Research Program.
- This funding opportunity was created on Apr 15, 2010 and posted on Apr 15, 2010.
- Applicants must submit their applications by Jul 15, 2010 Please refer to the full announcement, including Section IV for additional information on submission methods and due dates.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Native American tribal governments (Federally recognized) State governments City or township governments County governments Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Private institutions of higher education.
- See Section III of the announcement for additional eligibility information.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The Environmental Protection Agency (EPA) announced this Science to Achieve Results (STAR) research opportunity to push forward computational toxicology methods that can better connect environmental exposures to biological effects in a rigorous, quantitative way. The core focus is on building biologically based, multi-scale models that describe dose-response relationships and explain how an environmental agent interacts with toxicity pathways, starting at lower levels such as molecular or cellular events and linking those effects upward through tissues, organs, and whole-organism outcomes. In practical terms, the EPA was looking for projects that go beyond simple correlation and instead produce models that are mechanistic or biologically grounded enough to improve how scientists and risk assessors predict toxicity from exposure and interpret what a measured biological change actually means for health outcomes.
A second major emphasis of the solicitation is the data foundation behind these models. Because multi-scale modeling depends on pulling together diverse datasets (for example, high-throughput screening results, omics data, pathway information, and in vivo or epidemiological findings), the EPA explicitly called for research on how those underlying data can be managed, organized, documented, and shared so they are easier for other researchers and risk assessors to access and reuse. That means attention not only to model development, but also to practical solutions for data standards, metadata, curation approaches, and sharing mechanisms that reduce barriers to interpretation and enable broader community use. The overall intent is to make these modeling and data systems more interoperable and transparent so that outputs can more readily support environmental decision-making and risk assessment.
Administratively, this was a discretionary funding opportunity offered as grants and cooperative agreements under CFDA 66.509 (Science to Achieve Results (STAR) Research Program). EPA anticipated making about four awards, with an estimated total program funding level of $3,000,000 and a maximum award size (ceiling) of $750,000. There was no cost sharing or matching requirement listed. The opportunity was posted on April 15, 2010, with an application deadline (closing date) of July 15, 2010, and it was archived on August 14, 2010.
Eligible applicants included federally recognized Native American tribal governments, state governments, and local governments such as cities/townships and counties, along with public/state-controlled institutions of higher education and private institutions of higher education. The announcement also indicated that other entities might be eligible depending on the detailed eligibility language in Section III of the full solicitation, which applicants were expected to consult for any additional restrictions or clarifications. For those who could not access the full announcement electronically, the contact listed was Pasky Pascual at 202-343-9710.
Frequently Asked Questions (FAQs)
What is this EPA STAR funding opportunity about?
This Environmental Protection Agency (EPA) Science to Achieve Results (STAR) research opportunity focuses on advancing computational toxicology methods that connect environmental exposures to biological effects in a rigorous, quantitative way. The goal is to improve how toxicity is predicted from exposure and how measured biological changes are interpreted for potential health outcomes.
What kinds of research approaches is EPA emphasizing?
The solicitation emphasizes biologically based, multi-scale modeling. Projects are expected to develop models that describe dose-response relationships and explain how an environmental agent interacts with toxicity pathways, starting from lower-level biological events (such as molecular or cellular changes) and linking those effects up through tissues, organs, and whole-organism outcomes.
What does "multi-scale" mean in this context?
Multi-scale refers to linking biological effects across different levels of biological organization. For example, a model might begin with molecular or cellular events and then connect those to tissue-level changes, organ-level impacts, and ultimately outcomes observed at the whole-organism level.
Does the opportunity prioritize mechanistic models over correlations?
Yes. EPA was looking for projects that go beyond simple correlation and instead produce mechanistic or biologically grounded models. The intent is to create models that are strong enough to support improved toxicity prediction from exposure and clearer interpretation of biological changes in terms of health outcomes.
What is meant by "dose-response" in the solicitation?
Dose-response refers to the relationship between the amount of exposure to an environmental agent and the resulting biological effect. The opportunity calls for models that can quantitatively describe and explain these relationships in a biologically based way.
How does "toxicity pathways" fit into the research focus?
The solicitation highlights explaining how an environmental agent interacts with toxicity pathways. In practice, that means linking exposures to the biological pathways involved in toxicity, starting at early biological events and connecting them to higher-level outcomes.
Is data management part of what EPA wants funded?
Yes. A major emphasis is the data foundation needed for multi-scale modeling. EPA explicitly called for research on how underlying data can be managed, organized, documented, and shared to improve access and reuse by other researchers and risk assessors.
What types of data are implied as relevant for these models?
The solicitation describes pulling together diverse datasets, including examples such as high-throughput screening results, omics data, pathway information, and in vivo or epidemiological findings.
What kinds of data-related solutions does EPA mention?
The opportunity points to practical solutions such as data standards, metadata, curation approaches, and sharing mechanisms. The intent is to reduce barriers to interpretation and enable broader community use of the modeling and data systems.
Why does EPA emphasize interoperability and transparency?
The overall intent is to make modeling and data systems more interoperable and transparent so outputs can more readily support environmental decision-making and risk assessment.
What type of funding mechanism is being used?
This is a discretionary funding opportunity offered as grants and cooperative agreements under CFDA 66.509, the Science to Achieve Results (STAR) Research Program.
How many awards did EPA expect to make?
EPA anticipated making about four awards under this opportunity.
What was the total estimated funding level for the program?
The estimated total program funding level was $3,000,000.
What is the maximum award amount?
The maximum award size (ceiling) listed was $750,000.
Is there a cost-sharing or matching requirement?
No cost sharing or matching requirement was listed in the information provided.
When was the opportunity posted and when was it due?
The opportunity was posted on April 15, 2010, and the application deadline (closing date) was July 15, 2010.
Is the opportunity still open?
No. The opportunity was archived on August 14, 2010.
Who was eligible to apply based on the announcement summary?
Eligible applicants included federally recognized Native American tribal governments, state governments, and local governments (such as cities/townships and counties), along with public/state-controlled institutions of higher education and private institutions of higher education.
Could other organizations be eligible too?
The announcement indicated that other entities might be eligible depending on the detailed eligibility language in Section III of the full solicitation. Applicants were expected to consult the full solicitation for additional restrictions or clarifications.
What should applicants do if they need the detailed eligibility rules?
The summary points applicants to Section III of the full solicitation for detailed eligibility language and any additional restrictions or clarifications.
Who is the contact if the full announcement could not be accessed electronically?
The listed contact was Pasky Pascual at 202-343-9710 for those who could not access the full announcement electronically.
What is the CFDA number associated with this opportunity?
The opportunity is under CFDA 66.509, the Science to Achieve Results (STAR) Research Program.
How does this research relate to risk assessment and decision-making?
The intent is for biologically based models and improved data systems to make outputs more usable in environmental decision-making and risk assessment, including better prediction of toxicity from exposure and better interpretation of biological measurements for health outcomes.
Browse more opportunities from the same category: Environment
Next opportunity: Computational Toxicology Biologically Based Multi Scale Modeling
Previous opportunity: Computational Toxicology Biologically Based Multi Scale Modeling
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for EPA G2010 STAR C3
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (EPA G2010 STAR C3) also looked into and applied for these:
| Funding Opportunity |
|---|
| Computational Toxicology Biologically Based Multi Scale Modeling Apply for EPA G2010 STAR C4 Funding Number: EPA G2010 STAR C4 Agency: Environmental Protection Agency Category: Environment Funding Amount: $750,000 |
| Sand Resource Evaluation on the Outer Continental Shelf by the Florida Geological Survey, Louisiana Office of Coastal Protection and Restoration, and Virginia Division of Geology and Mineral Resources Apply for M10AS00005 Funding Number: M10AS00005 Agency: Bureau of Ocean Energy Management Category: Environment Funding Amount: $220,000 |
| Aerial Pesticide Applicator Training and Outreach Request for Applications (RFA) Apply for EPA OPP 2010 003 Funding Number: EPA OPP 2010 003 Agency: Environmental Protection Agency Category: Environment Funding Amount: $50,000 |
| National Tribal Air Association Operations Apply for EPA OAR IO 10 06 Funding Number: EPA OAR IO 10 06 Agency: Environmental Protection Agency Category: Environment Funding Amount: $335,000 |
| Cleaner Production Private Sector Partnerships Apply for S OES 10 RFA 0010 Funding Number: S OES 10 RFA 0010 Agency: Ocean and International Environmental Scientific Category: Environment Funding Amount: $693,000 |
| Monitoring, Data Management, and Special Studies South Florida Geographic Initiative, Water Quality Protection Program for the Florida Keys National Marine Sanctuary, and the Southeast Florida Coral Reef Initiative/Land Based Sources of Pollution Apply for EPA R4 WPD 2010 SFL Funding Number: EPA R4 WPD 2010 SFL Agency: Environmental Protection Agency Category: Environment Funding Amount: Case Dependent |
| Red Bluff Construction Technical Support Apply for R10AS20015 Funding Number: R10AS20015 Agency: Bureau of Reclamation Mid Pacific Region Category: Environment Funding Amount: $2,000,000 |
| Coral Reef Crime Scene Investigation Program Illegal Trade in Wildlife Products Derived from Coral Reef Ecosystems Apply for S OES 10 RFA 0012 Funding Number: S OES 10 RFA 0012 Agency: Ocean and International Environmental Scientific Category: Environment Funding Amount: $198,000 |
| Heart of the Highlands Trails System Project Apply for FWS R5 RW 10 048 Funding Number: FWS R5 RW 10 048 Agency: Fish and Wildlife Service Category: Environment Funding Amount: $500,000 |
| Rosewood Creek Area A Restoration Project Apply for R10AS20016 Funding Number: R10AS20016 Agency: Bureau of Reclamation Mid Pacific Region Category: Environment Funding Amount: $2,000,000 |
| Targeted Air Shed Grant Program Apply for EPA OAR IO 10 07 Funding Number: EPA OAR IO 10 07 Agency: Environmental Protection Agency Category: Environment Funding Amount: $3,350,000 |
| CESU Quantify the Frequency and Severity of Interactions bwteen Cruise Ships and Humpback Whales in Glacier Bay National Park Preserve Apply for J9815100613 Funding Number: J9815100613 Agency: National Park Service Category: Environment Funding Amount: $500,000 |
| Outdoor Information Center Apply for L10AS00071 Funding Number: L10AS00071 Agency: Bureau of Land Management Category: Environment Funding Amount: $350,000 |
| Tribal Environmental Education, Outreach and Support Program Apply for EPA OAR IO 10 08 Funding Number: EPA OAR IO 10 08 Agency: Environmental Protection Agency Category: Environment Funding Amount: Case Dependent |
| Chesapeake Bay Program Office Fiscal Year 2010 Request for Proposals (RFP) for the Development and Implementation of the Chesapeake Bay Innovative Nutrient and Sediment Reduction Program Apply for EPA R3 CBP 10 06 Funding Number: EPA R3 CBP 10 06 Agency: Environmental Protection Agency Category: Environment Funding Amount: $6,000,000 |
| FY10 Region 04 Wetland Program Development Grants Apply for EPA REG04WPDG 2010 Funding Number: EPA REG04WPDG 2010 Agency: Environmental Protection Agency Category: Environment Funding Amount: $600,000 |
| FY10 Region 8 Wetland Program Development Grants Apply for EPA REG8WPDG 2010 Funding Number: EPA REG8WPDG 2010 Agency: Environmental Protection Agency Category: Environment Funding Amount: $250,000 |
| Lake Tahoe Regional Development Program Apply for R10AF20021 Funding Number: R10AF20021 Agency: Bureau of Reclamation Mid Pacific Region Category: Environment Funding Amount: $400,000 |
| Arizona Hazardous Fuels Reduction Project Utilizing Veterans Apply for L10AS00072 Funding Number: L10AS00072 Agency: Bureau of Land Management Category: Environment Funding Amount: $500,000 |
| CERCLA SECTION 128(a) STATE IMPLEMENTATION SUPPORT GRANT Apply for EPA OSWER OBLR 10 07 Funding Number: EPA OSWER OBLR 10 07 Agency: Environmental Protection Agency Category: Environment Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "EPA G2010 STAR C3", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.