Opportunity Information: Apply for EPA G2010 STAR C4
Apply for EPA G2010 STAR C4
- The Environmental Protection Agency in the environment sector is offering a public funding opportunity titled "Computational Toxicology Biologically Based Multi Scale Modeling" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.509 Science To Achieve Results (STAR) Research Program.
- This funding opportunity was created on Apr 15, 2010 and posted on Apr 15, 2010.
- Applicants must submit their applications by Jul 15, 2010 Please refer to the full announcement, including Section IV for additional information on submission methods and due dates.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: County governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments City or township governments Native American tribal governments (Federally recognized) Private institutions of higher education.
- See Section III of the announcement for additional eligibility information.
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Opportunity Summary:
The Environmental Protection Agency (EPA) released this Science to Achieve Results (STAR) funding opportunity to support research that strengthens computational toxicology by building biologically based, multi-scale models that connect environmental exposures to measurable toxic effects. The core scientific goal is to develop quantitative dose-response models that can explain, predict, and clarify how specific environmental agents (for example, chemicals or pollutants) interact with toxicity pathways and ultimately lead to adverse outcomes. A key emphasis is spanning multiple levels of biological organization, meaning applicants are expected to bridge information across scales such as molecular and cellular pathway activity, tissue and organ responses, and whole-organism outcomes. In practical terms, the EPA is looking for modeling approaches that can translate mechanistic data into actionable dose-response relationships that are useful for understanding hazard, potency, and risk.
In addition to model development, the solicitation highlights a second major need: better management and sharing of the data that feed these models. The EPA is explicitly calling for research that improves how underlying datasets are organized, curated, stored, documented, and made accessible so that other researchers and risk assessors can find them, interpret them consistently, and reuse them with minimal friction. This includes improving transparency and usability of model inputs and outputs, which is especially important when models are intended to inform broader regulatory science and community risk assessment work. The overall intent is not only to advance modeling methods, but also to make the resulting data and modeling products easier to adopt and apply beyond the original research team.
This opportunity is a discretionary funding competition under Funding Opportunity Number EPA G2010 STAR C4, titled "Computational Toxicology Biologically Based Multi Scale Modeling." The funding instruments include cooperative agreements and grants, and it is categorized under environmental research activities. The EPA anticipated making about four awards, with an estimated total funding amount of $3,000,000. Individual awards were expected to be as high as $750,000, and the program did not require cost sharing or matching funds.
Eligibility was broad and included public and private institutions of higher education, as well as various government entities such as state governments, county governments, city or township governments, and federally recognized Native American tribal governments. The announcement notes that additional eligibility details were provided in Section III of the full solicitation, which applicants would need to consult for any specific restrictions or clarifications.
Key dates associated with the competition show it was posted and created on April 15, 2010, with an original and current closing date of July 15, 2010, and an archive date of August 14, 2010. The program is associated with CFDA number 66.509, the STAR Research Program. For applicants who had trouble accessing the full announcement, the EPA provided a point of contact: Pasky Pascual at (202) 343-9710.
Frequently Asked Questions (FAQs)
What is this EPA funding opportunity?
This is an Environmental Protection Agency (EPA) Science to Achieve Results (STAR) discretionary funding opportunity titled "Computational Toxicology Biologically Based Multi Scale Modeling" under Funding Opportunity Number EPA G2010 STAR C4.
What is the main purpose of the opportunity?
The opportunity is intended to support research that strengthens computational toxicology by developing biologically based, multi-scale models that connect environmental exposures to measurable toxic effects.
What is the core scientific goal of the research being funded?
The core goal is to develop quantitative dose-response models that can explain, predict, and clarify how specific environmental agents (such as chemicals or pollutants) interact with toxicity pathways and ultimately lead to adverse outcomes.
What kinds of environmental agents does the EPA mention?
The description gives examples such as chemicals or pollutants, in the context of agents that can interact with toxicity pathways and cause adverse outcomes.
What does "biologically based, multi-scale" mean in this solicitation?
It means applicants are expected to bridge information across multiple levels of biological organization, such as molecular and cellular pathway activity, tissue and organ responses, and whole-organism outcomes.
What types of models is the EPA looking for?
The EPA is looking for modeling approaches that translate mechanistic data into actionable dose-response relationships that are useful for understanding hazard, potency, and risk.
Is the opportunity focused only on model development?
No. In addition to model development, the solicitation highlights a second major need: improving the management and sharing of the data that feed the models.
What data-related improvements does the EPA call for?
The EPA explicitly calls for research that improves how underlying datasets are organized, curated, stored, documented, and made accessible so they can be found, interpreted consistently, and reused with minimal friction.
Why does the solicitation emphasize transparency and usability of data and models?
Because models are intended to inform broader regulatory science and community risk assessment work, the EPA emphasizes making model inputs and outputs transparent and usable so others can adopt and apply the products beyond the original research team.
What is the overall intent of the program beyond advancing modeling methods?
The intent is to advance modeling methods and also make resulting data and modeling products easier to adopt and apply by other researchers and risk assessors.
What type of funding instrument will be used?
The solicitation states that the funding instruments include cooperative agreements and grants.
How many awards were anticipated?
The EPA anticipated making about four awards.
What is the estimated total funding amount for the competition?
The estimated total funding amount was $3,000,000.
What is the maximum expected amount per award?
Individual awards were expected to be as high as $750,000.
Is cost sharing or matching required?
No. The program did not require cost sharing or matching funds.
Who is eligible to apply?
Eligibility was broad and included public and private institutions of higher education and government entities such as state governments, county governments, city or township governments, and federally recognized Native American tribal governments.
Are there additional eligibility rules or restrictions?
Yes. The announcement notes that additional eligibility details were provided in Section III of the full solicitation, which applicants would need to consult for any specific restrictions or clarifications.
What category or activity area is this opportunity under?
It is categorized under environmental research activities.
What is the CFDA number associated with this program?
The program is associated with CFDA number 66.509, the STAR Research Program.
When was the opportunity posted?
The opportunity was posted (and created) on April 15, 2010.
What was the closing date?
The original and current closing date was July 15, 2010.
When was the opportunity archived?
The archive date was August 14, 2010.
Who should be contacted for help accessing the full announcement?
The EPA provided a point of contact for applicants who had trouble accessing the full announcement: Pasky Pascual at (202) 343-9710.
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