Opportunity Information: Apply for RFA AA 15 004

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Research Projects (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
  • This funding opportunity was created on Dec 16, 2014 and posted on Dec 16, 2014.
  • Applicants must submit their applications by Mar 6, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $4,100,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 8 candidate(s).
  • Eligible applicants include: Special district governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts State governments City or township governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education For profit organizations other than small businesses County governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

The Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Research Projects (U01) opportunity (Funding Opportunity Number RFA-AA-15-004) is a National Institutes of Health cooperative agreement program designed to fund coordinated, multi-institution research that clarifies how repeated alcohol exposure during adolescence can cause long-lasting changes in the brain and behavior that persist into adulthood. The central scientific aim is to illuminate enduring alterations in complex brain function and behavior relationships that follow adolescent alcohol exposure, with an emphasis on how such exposure may disrupt brain maturation and influence adult capabilities.

This announcement specifically supports collaborative projects that operate as part of a broader NADIA consortium. Because it uses the U01 cooperative agreement mechanism, awardees are expected to work in close coordination with the NIH (including substantial programmatic involvement typical of cooperative agreements) and with other funded teams across institutions, rather than conducting fully independent, stand-alone studies. The overall structure is meant to accelerate progress by aligning methods, sharing insights, and producing more integrated conclusions about adolescent alcohol effects than any single lab could achieve alone.

A key boundary of the program is that it is limited to animal studies only. The rationale given is that the National Institute on Alcohol Abuse and Alcoholism (NIAAA) is prioritizing experimental work where alcohol dose levels and exposure windows can be carefully controlled. In practical terms, that means proposals are expected to use animal models to examine the consequences of repeated adolescent alcohol exposure, including how exposure timing, pattern, and dose may shape developmental trajectories and later adult outcomes. The intent is to leverage experimental control to make stronger causal inferences about how adolescent alcohol exposure alters neurobiological development and adult behavior.

Financially, the FOA anticipated making about 8 awards, with an estimated total funding level of $4,100,000. It is categorized as a discretionary funding opportunity, the activity category is health, and it falls under CFDA 93.273 (Alcohol Research Programs). There is no cost sharing or matching requirement, so applicants are not required to contribute non-federal funds as a condition of award.

Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations other than small businesses, small businesses, independent school districts, and a wide range of government bodies such as state governments, county governments, city or township governments, special district governments, public housing authorities/Indian housing authorities, and Native American tribal governments (federally recognized) as well as tribal organizations that are not federally recognized. The FOA also explicitly includes various mission-focused institution types and communities, such as Historically Black Colleges and Universities, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions, along with faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.

At the same time, there are clear restrictions on foreign participation. Non-domestic (non-U.S.) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed. In short, this initiative is designed for U.S.-based research organizations conducting animal studies under the consortium framework.

In terms of timing and status, the FOA was posted and created on December 16, 2014, with an original and final application closing date of March 6, 2015. The opportunity was archived on April 6, 2015, meaning it is no longer open for applications, but it remains useful as a reference point for the goals, structure, and requirements of the NADIA consortium approach.

For those looking for the full original announcement details, the FOA provided an NIH grants guide link (http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-15-004.html). For technical difficulties accessing the announcement, the contact listed was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

Frequently Asked Questions (FAQs)

What is the NADIA Research Projects (U01) funding opportunity?

This opportunity, titled "The Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Research Projects (U01)," is an NIH cooperative agreement program intended to support coordinated, multi-institution research on how repeated alcohol exposure during adolescence can produce lasting changes in the brain and behavior that persist into adulthood.

What is the Funding Opportunity Number (FOA) for this announcement?

The Funding Opportunity Number is RFA-AA-15-004.

What is the primary scientific goal of the program?

The central aim is to clarify enduring alterations in complex brain function and behavior relationships that follow repeated adolescent alcohol exposure, with emphasis on how alcohol exposure may disrupt brain maturation and influence adult capabilities.

What type of award mechanism is used (and what does it mean for applicants)?

The program uses the U01 cooperative agreement mechanism. This means funded projects are expected to involve substantial NIH programmatic involvement and to work in close coordination with NIH and other funded consortium teams, rather than operating as fully independent, stand-alone studies.

Does this FOA require participation in a consortium?

Yes. The announcement specifically supports collaborative projects that operate as part of the broader NADIA consortium structure, with an expectation of coordination across institutions and research teams.

Are human studies allowed under this opportunity?

No. A key boundary of the program is that it is limited to animal studies only.

Why does the FOA limit the research to animal studies?

The rationale described is that NIAAA is prioritizing experimental work where alcohol dose levels and exposure windows can be carefully controlled, enabling stronger causal inferences about how adolescent alcohol exposure alters neurobiological development and adult behavior.

What kinds of research questions or variables are emphasized?

Proposals are expected to use animal models to examine consequences of repeated adolescent alcohol exposure, including how the timing, pattern, and dose of exposure may shape developmental trajectories and later adult outcomes.

How many awards were anticipated, and what was the total expected funding level?

The FOA anticipated making about 8 awards, with an estimated total funding level of $4,100,000.

Is cost sharing or matching required?

No. There is no cost sharing or matching requirement; applicants are not required to contribute non-federal funds as a condition of award.

What is the activity category and CFDA number associated with this opportunity?

The activity category is health, and it falls under CFDA 93.273 (Alcohol Research Programs).

What types of organizations were eligible to apply?

Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include (as described in the announcement): public and state-controlled institutions of higher education; private institutions of higher education; nonprofits (501(c)(3) and non-501(c)(3)); for-profit organizations other than small businesses; small businesses; independent school districts; and government entities including state, county, and city/township governments, special district governments, public housing authorities/Indian housing authorities, and Native American tribal governments (federally recognized), as well as tribal organizations that are not federally recognized. The FOA also explicitly includes HBCUs, HSIs, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.

Are foreign (non-U.S.) organizations eligible to apply?

No. Non-domestic (non-U.S.) entities are not eligible to apply.

Can a U.S. organization include a non-U.S. (non-domestic) component?

No. Non-domestic components of U.S. organizations are not eligible under this opportunity.

Are foreign components allowed if defined under NIH policy?

No. Foreign components (as defined by NIH policy) are not allowed.

When was the FOA posted, and what were the application due dates?

The FOA was posted/created on December 16, 2014. The original and final application closing date was March 6, 2015.

Is this funding opportunity still open for applications?

No. The opportunity was archived on April 6, 2015, meaning it is no longer open for applications.

Where can someone find the full original announcement?

The FOA referenced the NIH Grants Guide page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-15-004.html

Who was listed as the contact for technical difficulties accessing the announcement?

The contact listed for technical difficulties was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

What is the overall program rationale for using a coordinated, multi-institution approach?

The structure is intended to accelerate progress by aligning methods, sharing insights, and producing more integrated conclusions about adolescent alcohol effects than any single lab could achieve alone.

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