Opportunity Information: Apply for RFA CA 16 007
Apply for RFA CA 16 007
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Coordinating Center for Barrett's Esophagus Translational Research Network (BETRNet)(U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.396.
- This funding opportunity was created on Mar 17, 2016 and posted on Mar 17, 2016.
- Applicants must submit their applications by May 23, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Coordinating Center for the Barrett's Esophagus Translational Research Network (BETRNet) (U24) is a National Cancer Institute (NCI) cooperative agreement funding opportunity designed to support the central hub of a larger, multi-site research network focused on Barrett's esophagus and esophageal adenocarcinoma. The overall purpose of BETRNet is to respond to the increasing incidence of esophageal adenocarcinoma in the United States by accelerating translational research that clarifies the underlying biology of both the cancer and its main precursor condition, Barrett's esophagus. The long-term intent is that a stronger biological understanding will lead to validated prevention approaches and better patient management strategies, rather than fragmented or purely exploratory efforts.
Under this program structure, BETRNet is made up of three to four multi-institutional, trans-disciplinary Research Centers supported through a companion announcement (RFA-CA-16-006), plus a single Coordinating Center supported through this announcement (RFA-CA-16-007). The Coordinating Center is not simply an administrative office; it is expected to actively integrate and enable collaboration across the network so that the separate Research Centers function as a cohesive program with shared standards, shared resources, and coordinated scientific activity.
The Coordinating Center's core responsibilities concentrate on three major areas. First, it is responsible for network interactions and collaborations, meaning it helps organize communication, align research activities across sites, and support the day-to-day mechanisms that make multi-institutional work feasible (such as coordinating meetings, facilitating cross-center working groups, and supporting common processes that reduce duplication and improve consistency). Second, it participates in the patient registry and virtual biorepository, which is intended to serve as a centralized, shared resource for the entire BETRNet program. The goal of this registry-virtual biorepository component is to enable researchers across the network to access well-organized patient-related data and associated biospecimen information through a unified framework, improving the ability to conduct robust, comparable analyses and to validate findings across cohorts. Third, the Coordinating Center supports cross-BETRNet pilot projects, which are collaborative efforts spanning multiple centers and intended to spark new directions, test shared hypotheses, or rapidly evaluate promising translational concepts that benefit from network-wide participation.
From an administrative standpoint, this is a discretionary award made as a cooperative agreement (U24), which typically indicates substantial programmatic involvement from the funding agency compared with a standard grant. The opportunity is listed under health-related activity categories and includes CFDA numbers 93.393, 93.394, and 93.396. Eligible applicants are broad and include state and county governments, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education where specified), for-profit organizations other than small businesses, small businesses, and other entities as further clarified in the full eligibility text. The agency is HHS-NIH (specifically NCI). The FOA was posted March 17, 2016, with an application closing date of May 23, 2016.
Funding details indicate a single Coordinating Center award is expected, with an award ceiling of $250,000. In practical terms, the funding is meant to support the infrastructure and coordination functions that allow the broader BETRNet research enterprise to operate effectively, including enabling consistent collaboration across the Research Centers, ensuring participation in and utility of the shared registry/virtual biorepository, and catalyzing pilot projects that leverage the full network. The unifying theme is to create a coordinated, resource-sharing environment that increases the pace and quality of translational discoveries relevant to preventing and managing Barrett's esophagus progression to esophageal adenocarcinoma.
Frequently Asked Questions (FAQs)
What is the BETRNet Coordinating Center (U24) funding opportunity?
The Coordinating Center for the Barrett's Esophagus Translational Research Network (BETRNet) (U24) is a National Cancer Institute (NCI) cooperative agreement funding opportunity. It supports the central hub of a larger, multi-site research network focused on Barrett's esophagus and esophageal adenocarcinoma.
What is the overall purpose of BETRNet?
BETRNet is intended to respond to the increasing incidence of esophageal adenocarcinoma in the United States by accelerating translational research. The network aims to clarify the underlying biology of esophageal adenocarcinoma and its main precursor condition, Barrett's esophagus, with a long-term goal of enabling validated prevention approaches and better patient management strategies.
Which agency is offering this opportunity?
The sponsoring agency is HHS-NIH, specifically the National Cancer Institute (NCI).
What type of award is this, and what does that imply?
This is a discretionary award made as a cooperative agreement (U24). A cooperative agreement typically indicates substantial programmatic involvement from the funding agency compared with a standard grant mechanism.
How is BETRNet structured?
BETRNet is composed of three to four multi-institutional, trans-disciplinary Research Centers supported through a companion announcement (RFA-CA-16-006), plus a single Coordinating Center supported through this announcement (RFA-CA-16-007).
Is the Coordinating Center only an administrative office?
No. The Coordinating Center is expected to actively integrate and enable collaboration across the network so the Research Centers function as a cohesive program with shared standards, shared resources, and coordinated scientific activity.
What are the major responsibility areas for the Coordinating Center?
The Coordinating Center responsibilities are organized around three major areas: (1) network interactions and collaborations, (2) participation in the patient registry and virtual biorepository, and (3) support for cross-BETRNet pilot projects.
What does "network interactions and collaborations" include?
This includes organizing communication and aligning research activities across sites, and supporting mechanisms that make multi-institutional work feasible. Examples described include coordinating meetings, facilitating cross-center working groups, and supporting common processes to reduce duplication and improve consistency.
What is the patient registry and virtual biorepository component?
It is intended to be a centralized, shared resource for the entire BETRNet program. It is designed to enable researchers across the network to access well-organized patient-related data and associated biospecimen information through a unified framework.
Why is the registry/virtual biorepository important for BETRNet?
The shared framework is meant to improve the ability to conduct robust, comparable analyses and to validate findings across cohorts by standardizing access to patient-related data and biospecimen information across the network.
What are cross-BETRNet pilot projects?
These are collaborative efforts spanning multiple centers. They are intended to spark new directions, test shared hypotheses, or rapidly evaluate promising translational concepts that benefit from network-wide participation.
How many Coordinating Center awards are expected?
A single Coordinating Center award is expected.
What is the maximum (ceiling) amount of funding for this award?
The award ceiling is $250,000.
What is the funding intended to support in practical terms?
The funding is intended to support infrastructure and coordination functions that allow the broader BETRNet research enterprise to operate effectively. This includes enabling consistent collaboration across Research Centers, ensuring participation in and utility of the shared registry/virtual biorepository, and catalyzing pilot projects that leverage the full network.
What are the key scientific focus areas of the overall network?
The network focuses on Barrett's esophagus and esophageal adenocarcinoma, with emphasis on translational research that clarifies underlying biology and supports progress toward validated prevention approaches and improved patient management.
What is the relationship between this announcement and the companion Research Center announcement?
This announcement (RFA-CA-16-007) supports the single Coordinating Center. The companion announcement (RFA-CA-16-006) supports three to four Research Centers that, together with the Coordinating Center, make up BETRNet.
Who is eligible to apply?
Eligible applicants are broad and include: state and county governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education where specified); for-profit organizations other than small businesses; small businesses; and other entities as further clarified in the full eligibility text.
What activity categories and CFDA numbers are associated with this opportunity?
The opportunity is listed under health-related activity categories and includes CFDA numbers 93.393, 93.394, and 93.396.
When was the FOA posted and when was the application due?
The FOA was posted on March 17, 2016, and the application closing date was May 23, 2016.
What is the main value of having a Coordinating Center within BETRNet?
The Coordinating Center is intended to prevent fragmented or purely exploratory efforts by creating a coordinated, resource-sharing environment. It helps ensure shared standards, shared resources, and coordinated scientific activity across multiple sites, increasing the pace and quality of translational discoveries.
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