Opportunity Information: Apply for RFA HL 10 022
Apply for RFA HL 10 022
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Coordinating Center for Systems Biology Approach to the Mechanisms of Tuberculosis (TB) Latency and Reactivation (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Dec 9, 2009 and posted on Dec 9, 2009.
- Applicants must submit their applications by Mar 24, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,450,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Private institutions of higher education Independent school districts City or township governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments State governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This grant opportunity (RFA-HL-10-022) from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, seeks applications to serve as the single Data Coordinating Center for a larger research program called the NHLBI Systems Biology Approach to the Mechanisms of Tuberculosis (TB) Latency and Reactivation. The overall program is structured around multiple TB Systems Biology Centers (funded under a companion announcement, RFA-HL-10-015) plus one centralized coordinating hub. The scientific aim across the full program is to better understand why Mycobacterium tuberculosis can persist in a latent state and what host and microbial factors drive reactivation, with an emphasis on processes occurring in the lung.
A key feature of the program is its use of integrated systems biology. In practical terms, this means bringing together biologists, computational scientists, and engineers to study TB latency and reactivation as a complex, multi-factor biological system rather than a single pathway or isolated mechanism. The FOA emphasizes multiscale computational modeling, meaning models that can connect events across different biological levels (for example, molecular and cellular behavior, immune signaling networks, tissue-level lung responses, and broader host-pathogen interaction dynamics). The research focus is explicitly on host lung responses to M. tuberculosis and on host-microbial interactions that shape whether infection remains contained (latency) or progresses back to active disease (reactivation).
Another central expectation is deep integration of different data types. Applicants and the overall program are expected to combine data from omics approaches (such as genomics, transcriptomics, proteomics, metabolomics, or similar high-dimensional datasets) with biological and immunological measurements to support model building and validation. The resulting theoretical and computational models are expected to be usable in ways that allow real testing, specifically in humans or in non-human primates, rather than remaining purely descriptive or exploratory.
Human samples and/or human data are required for this program, reflecting the goal of generating insights that are directly relevant to human TB latency and reactivation. At the same time, the FOA encourages the use of animal models and animal datasets as complementary tools to help build, refine, and test models, as long as the work supports a better understanding of the human condition. In other words, animal work is positioned as a way to strengthen inference and validation, not as a substitute for human-based evidence.
From an administrative and funding standpoint, this is a discretionary NIH grant using the R01 mechanism, categorized under Health and associated with CFDA 93.838 (Lung Diseases Research). The FOA was posted on December 9, 2009, with an original and current closing date of March 24, 2010, and an archive date of April 24, 2010. The estimated total funding listed is $3,450,000 for the opportunity, with no cost sharing or matching requirement.
Eligibility is broad and includes many organization types: public and private institutions of higher education, nonprofits (including 501(c)(3) and those without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, state and local governments (including counties, cities/townships, special districts), independent school districts, public housing authorities, and tribal governments and organizations. Additional eligible applicants explicitly include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based and community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
In short, the opportunity is not asking for a standalone TB research project so much as it is asking for an institution to act as the program-wide coordinating backbone for a multi-center systems biology effort. The Coordinating Center role is meant to support and unify the broader NHLBI-funded TB Systems Biology Centers by enabling organized, integrated handling of complex, multi-source datasets and by facilitating collaboration around model-driven research on TB latency and reactivation in the lung.
Frequently Asked Questions (FAQs)
What is the funding opportunity number for this grant?
The funding opportunity announcement (FOA) is RFA-HL-10-022.
Which agency is offering this opportunity?
This opportunity is offered by the National Heart, Lung, and Blood Institute (NHLBI), which is part of the National Institutes of Health (NIH).
What is the purpose of this FOA?
The FOA seeks applications to serve as the single Data Coordinating Center (DCC) for the NHLBI research program titled "Systems Biology Approach to the Mechanisms of Tuberculosis (TB) Latency and Reactivation."
Is this grant for a standalone tuberculosis research project?
No. The opportunity is primarily for an institution to act as the program-wide coordinating backbone (the Data Coordinating Center) for a multi-center systems biology effort, rather than proposing an independent TB research project disconnected from the larger program.
How is the overall program structured?
The program includes multiple TB Systems Biology Centers funded under a companion announcement (RFA-HL-10-015) plus one centralized Data Coordinating Center funded under this FOA (RFA-HL-10-022).
What is the companion announcement referenced by this FOA?
The companion announcement is RFA-HL-10-015, which funds the TB Systems Biology Centers that will work in coordination with the single Data Coordinating Center.
What scientific problem is the overall program trying to address?
The overall program aims to better understand why Mycobacterium tuberculosis can persist in a latent state and what host and microbial factors drive reactivation, with an emphasis on processes occurring in the lung.
What does "systems biology" mean in the context of this program?
In this program, systems biology refers to an integrated approach that brings together biologists, computational scientists, and engineers to study TB latency and reactivation as a complex, multi-factor biological system rather than focusing on a single pathway or isolated mechanism.
What is meant by "multiscale computational modeling" here?
Multiscale computational modeling refers to models designed to connect biological events across different levels, such as molecular and cellular behavior, immune signaling networks, tissue-level lung responses, and broader host-pathogen interaction dynamics.
What is the specific research focus area emphasized by the FOA?
The FOA emphasizes host lung responses to M. tuberculosis and host-microbial interactions that influence whether infection remains latent or reactivates to active disease.
What kinds of data are expected to be integrated across the program?
The program expects deep integration of multiple data types, including omics datasets (for example genomics, transcriptomics, proteomics, metabolomics, or similar high-dimensional datasets) along with biological and immunological measurements to support model building and validation.
Are the computational models expected to be testable?
Yes. Theoretical and computational models are expected to be usable in ways that support real testing and validation, specifically in humans or in non-human primates, rather than remaining purely descriptive or exploratory.
Are human samples or human data required?
Yes. Human samples and/or human data are required as part of the program, reflecting the goal of producing insights directly relevant to human TB latency and reactivation.
Are animal models allowed or encouraged?
Yes. The FOA encourages the use of animal models and animal datasets as complementary tools to build, refine, and test models, as long as the work supports improved understanding of the human condition and is not used as a substitute for human-based evidence.
What role does the lung play in the program's emphasis?
The program places explicit emphasis on processes occurring in the lung, including lung-specific host responses and tissue-level dynamics relevant to TB latency and reactivation.
What NIH grant mechanism is used for this opportunity?
This is a discretionary NIH grant using the R01 mechanism.
What is the CFDA number and category associated with this opportunity?
The opportunity is associated with CFDA 93.838, categorized as Lung Diseases Research.
What is the estimated total funding amount listed for this opportunity?
The estimated total funding listed is $3,450,000.
Is cost sharing or matching required?
No. The opportunity states that there is no cost sharing or matching requirement.
When was the FOA posted?
The FOA was posted on December 9, 2009.
What is the closing date for applications?
The original and current closing date listed is March 24, 2010.
When is the archive date?
The archive date listed is April 24, 2010.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofits (including 501(c)(3) and nonprofits without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and a wide range of government entities.
Are state and local government entities eligible?
Yes. Eligible applicants include state governments and local governments, including counties, cities/townships, and special districts.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations are included in the eligibility list.
Are independent school districts eligible?
Yes. Independent school districts are specifically included as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities are included as eligible applicants.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are listed among eligible applicants.
Are minority-serving institutions included in the eligible applicant types?
Yes. The eligibility list explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Can faith-based and community-based organizations apply?
Yes. Faith-based and community-based organizations are explicitly listed as eligible applicants.
Are regional organizations eligible?
Yes. Regional organizations are included in the eligibility list.
Are eligible federal agencies allowed to apply?
Yes. The eligibility list includes eligible federal agencies.
What is the central role expected of the Data Coordinating Center?
The Data Coordinating Center is expected to serve as the centralized coordinating hub that supports and unifies the TB Systems Biology Centers by enabling organized, integrated handling of complex, multi-source datasets and facilitating collaboration around model-driven research on TB latency and reactivation in the lung.
How does this coordinating role relate to collaboration across the program?
The FOA describes the coordinating center as a unifying hub intended to facilitate collaboration among multiple TB Systems Biology Centers, particularly around integrating datasets and supporting modeling and validation efforts across the program.
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