Opportunity Information: Apply for PAR 14 160
Apply for PAR 14 160
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research.
- This funding opportunity was created on Mar 24, 2015 and posted on Mar 19, 2014.
- Applicants must submit their applications by Jan 29, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses County governments Private institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Independent school districts Public housing authorities/Indian housing authorities Special district governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply.Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01)" (Funding Opportunity Number PAR-14-160) is a National Institutes of Health program led by the National Cancer Institute (NCI). It is structured as a cooperative agreement (U01), which generally means the award supports a project where NCI staff are expected to have substantial involvement alongside the awardee, especially around coordination, shared expectations, and stewardship of core resources. The focus is not on a single hypothesis-driven research study in the traditional sense, but on building and sustaining the essential infrastructure that makes large cancer epidemiology cohorts scientifically productive over time, while also encouraging methodological work that improves how cohort science is conducted.
At its core, the FOA is designed to strengthen Cancer Epidemiology Cohorts (CECs) by funding the functions that keep cohorts viable, usable, and high impact. This includes support for the "core functions" that make cohorts work: maintaining cohort operations, ensuring high-quality data collection and management, supporting follow-up and outcome ascertainment, managing biospecimens where relevant, and enabling secure, efficient access and use of cohort resources by investigators. The announcement makes clear that NCI intends this support to apply both to cohorts that already exist and to new cohorts being developed, as long as the application is centered on infrastructure and core operational capacity rather than only stand-alone research aims. The FOA also notes that it can provide support for core functions of cohorts that are currently funded under other mechanisms within NCI, particularly within the Epidemiology and Genomics Research Program (EGRP) and other groups in the Division of Cancer Control and Population Sciences (DCCPS). In practice, that signals an effort to stabilize and standardize cohort support across NCI and to keep critical cohort resources from being fragmented across multiple short-term project grants.
A second major emphasis is methodological research tied to cohort science. While the backbone of the award is infrastructure, the FOA explicitly welcomes work that improves methods used in cancer epidemiology cohorts. That can include innovations in study design, participant recruitment and retention strategies, approaches to exposure assessment, outcome validation, biospecimen handling and quality control, data harmonization across studies, linkage methods (for example, linking cohort data to cancer registries, mortality files, electronic health records, or claims), and analytic methods that address common cohort challenges like missing data, selection bias, measurement error, time-varying exposures, or complex sampling. The intent is to fund methodological advances that are practically grounded in cohort operations and that improve the rigor, efficiency, and reproducibility of cohort-based cancer research.
This opportunity is categorized as discretionary funding and is listed under CFDA 93.393 (Cancer Cause and Prevention Research). It does not require cost sharing or matching, which lowers the barrier for many applicants that might otherwise struggle to provide non-federal contributions for infrastructure-heavy projects. The announcement was posted March 19, 2014, with record creation noted March 24, 2015, and it shows multiple dates related to closing and archiving, including an original closing date of March 10, 2017, a current closing date listed as January 29, 2015, and an archive date of March 1, 2015. Those dates indicate this is an older, now-archived opportunity, so anyone looking to apply today would typically need to find a current, active successor FOA or contact NCI program staff to identify the appropriate modern mechanism.
Eligibility is broad and intentionally inclusive, reflecting the fact that cancer cohort infrastructure can be housed in many different organizational settings. Eligible applicants include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes tribal governments and tribal organizations (federally recognized and other than federally recognized), tribally controlled colleges and universities, and regional organizations. Importantly, non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions, and foreign components of U.S. organizations are allowed consistent with NIH policy. The eligibility language also highlights a range of institution types often emphasized in federal outreach and equity efforts, including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, and eligible federal agencies.
In summary, PAR-14-160 is best understood as an NCI-driven effort to keep cancer epidemiology cohorts strong, functional, and methodologically modern by funding the infrastructure that supports cohort operations and by encouraging practical methodological advances that improve the quality and usability of cohort data and resources. It is a cooperative agreement meant to enable coordination and shared priorities between NCI and awardees, with broad eligibility across academic, nonprofit, governmental, tribal, and international organizations. The full archived announcement and details were provided through the NIH Grants Guide webpage associated with PAR-14-160.
FAQs: Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01) - PAR-14-160
What is the name of this grant opportunity?
The opportunity is titled "Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-14-160.
Which federal agency and NIH institute lead this program?
This is a National Institutes of Health (NIH) program led by the National Cancer Institute (NCI).
What type of award mechanism is this?
This opportunity uses a cooperative agreement (U01) mechanism.
What does a cooperative agreement (U01) generally mean for how the project is run?
A U01 cooperative agreement generally indicates that NCI staff are expected to have substantial involvement with the awardee. That involvement is described in terms of coordination, shared expectations, and stewardship of core cohort resources, rather than the award operating with minimal federal involvement.
What is the main purpose of this FOA?
The FOA is designed to build and sustain essential infrastructure that keeps large cancer epidemiology cohorts scientifically productive over time, while also supporting methodological work that improves how cohort science is conducted.
Is this FOA mainly about funding a single hypothesis-driven research study?
No. The focus is not on a single traditional hypothesis-driven research study. The emphasis is on core infrastructure and operational capacity for cohorts, plus practical methodological improvements tied to cohort science.
What are "Cancer Epidemiology Cohorts (CECs)" in the context of this FOA?
In this FOA, CECs refers to large cohort resources used for cancer epidemiology research, where the funding priority is ensuring the cohort remains viable, usable, and high impact through strong core operations and modern methods.
What kinds of "core functions" can be supported for a cohort?
The FOA describes support for core functions such as maintaining cohort operations, ensuring high-quality data collection and management, supporting follow-up and outcome ascertainment, managing biospecimens where relevant, and enabling secure and efficient access to cohort resources by investigators.
Does this FOA support both existing cohorts and new cohorts?
Yes. The FOA indicates support can apply to cohorts that already exist and to new cohorts being developed, as long as the application is centered on infrastructure and core operational capacity rather than only stand-alone research aims.
Can this FOA support core functions for cohorts already funded under other NCI mechanisms?
Yes. The FOA notes it can provide support for core functions of cohorts that are currently funded under other mechanisms within NCI, particularly within the Epidemiology and Genomics Research Program (EGRP) and other groups in the Division of Cancer Control and Population Sciences (DCCPS).
Why does the FOA emphasize infrastructure support across NCI?
Based on the description provided, the FOA signals an intent to stabilize and standardize cohort support and reduce the risk that critical cohort resources become fragmented across multiple short-term project grants.
What is the methodological research component meant to do?
While infrastructure is the backbone of the award, the FOA welcomes methodological research that improves methods used in cancer epidemiology cohorts in ways that are practically grounded in cohort operations.
What kinds of methodological topics are explicitly encouraged?
Examples described include innovations in study design; participant recruitment and retention; exposure assessment; outcome validation; biospecimen handling and quality control; data harmonization across studies; linkage methods (such as linking to cancer registries, mortality files, electronic health records, or claims); and analytic methods addressing missing data, selection bias, measurement error, time-varying exposures, and complex sampling.
Are data linkages specifically mentioned as an area of interest?
Yes. The FOA mentions linkage methods, including linking cohort data to sources such as cancer registries, mortality files, electronic health records, and claims.
What is the intended outcome of funding methodological work under this FOA?
The intent is to support advances that improve the rigor, efficiency, and reproducibility of cohort-based cancer research and increase the quality and usability of cohort data and resources.
What is the CFDA number and program area listed for this opportunity?
This opportunity is listed under CFDA 93.393, described as Cancer Cause and Prevention Research.
Does the FOA require cost sharing or matching funds?
No. The opportunity states that it does not require cost sharing or matching.
Is this an active funding opportunity?
The dates provided indicate this is an older, archived opportunity. The announcement shows multiple closing/archiving-related dates, suggesting it is not currently open for new applications and that applicants would typically need to identify a current successor FOA or contact NCI program staff for updated guidance.
What dates are shown for posting, record creation, closing, and archiving?
The information provided states the FOA was posted March 19, 2014, with record creation noted March 24, 2015. It lists multiple dates including an original closing date of March 10, 2017, a current closing date listed as January 29, 2015, and an archive date of March 1, 2015.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations (including small businesses and other for-profits); and many government entities (state, county, city/township, special district, independent school districts, and public housing authorities/Indian housing authorities).
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes tribal governments (federally recognized and other than federally recognized), tribal organizations, and tribally controlled colleges and universities.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA states that non-U.S. entities are eligible, including foreign organizations and foreign institutions, and that foreign components of U.S. organizations are allowed consistent with NIH policy.
Does the eligibility language mention specific institution categories often included in federal outreach efforts?
Yes. The provided eligibility language highlights institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations, as well as eligible federal agencies.
Where were the official details for this opportunity made available?
The full (archived) announcement and details were provided through the NIH Grants Guide webpage associated with PAR-14-160.
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