Opportunity Information: Apply for PAR 12 206
Apply for PAR 12 206
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Decreasing Patient Radiation Dose from CT Imaging Achieving Sub mSv Studies (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health.
- This funding opportunity was created on Jul 27, 2012 and posted on Jun 13, 2012.
- Applicants must submit their applications by Sep 11, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments County governments Independent school districts Native American tribal governments (Federally recognized) Small businesses Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The grant opportunity "Decreasing Patient Radiation Dose from CT Imaging Achieving Sub mSv Studies (U01)" (Funding Opportunity Number PAR-12-206) is a National Institutes of Health (NIH) funding announcement aimed at pushing computed tomography (CT) imaging toward much lower radiation exposure while keeping the diagnostic value that makes CT so important in modern medicine. CT scans have become central to diagnosing and managing many conditions because they are fast, widely available, and produce detailed images that can guide treatment decisions. At the same time, CT uses ionizing radiation, and repeated exposure over a lifetime can add up. That cumulative dose is associated with a higher potential risk of radiation-related harms, including increased lifetime cancer risk, which is why clinicians are often careful to balance the expected clinical benefit of a CT scan against possible long-term risks and to consider non-ionizing alternatives when appropriate.
The core purpose of this FOA is to stimulate research that meaningfully reduces the radiation dose patients receive from CT imaging without sacrificing the image quality and clinical confidence needed for diagnosis. In practical terms, the announcement is looking for innovations that can shift the usual risk-benefit calculation further toward benefit by lowering the radiation component of the equation. The stated goal is ambitious: research outcomes should enable routine CT exams to be performed at patient radiation exposures below 1 millisievert (sub-mSv). For context, that target is meant to represent a substantial reduction from many common CT protocols, and it signals NIH interest in work that could change standard practice rather than only producing modest, incremental improvements.
This opportunity uses a U01 Cooperative Agreement mechanism, which generally indicates that NIH expects substantial programmatic involvement during the project period compared with a standard research grant. In cooperative agreements, awardees typically conduct the research while coordinating closely with NIH staff on milestones, progress, and program priorities, which fits a topic where translation into broadly usable methods, protocols, or technologies is a central objective. The funding activity category is Health, and the CFDA number listed is 93.286, identified as "Discovery and Applied Research for Technological Innovations to Improve Human Health." There is no cost sharing or matching requirement stated for applicants, reducing the need for institutions to bring additional mandatory funds to the project.
Eligibility is broad and includes many types of U.S.-based organizations and public entities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status; small businesses; and for-profit organizations other than small businesses. The FOA also calls out additional eligible groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, U.S. territories or possessions, and certain tribal governments (including federally recognized tribes and other Indian/Native American tribal governments). Foreign institutions (non-U.S. entities) are not eligible to apply, and foreign components as defined by the NIH Grants Policy Statement are not allowed. However, non-domestic components of U.S. organizations are eligible, which can matter for multi-site work where part of the effort or data may involve non-U.S. facilities under a U.S. applicant organization.
Administratively, the opportunity was posted on June 13, 2012, with a current closing date of September 11, 2014, and an archive date of October 12, 2014, meaning it is no longer accepting applications. The sponsoring agency is the National Institutes of Health, and the full announcement is referenced at http://grants.nih.gov/grants/guide/pa-files/PAR-12-206.html. For access or technical issues with the announcement, the contact point provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, the FOA is best understood as a targeted NIH push to accelerate research and development that makes very-low-dose CT clinically routine. It emphasizes solutions that reduce patient radiation exposure while preserving the diagnostic strengths of CT, with a clear performance destination of sub-1 mSv patient doses in everyday scanning rather than only in niche or experimental settings.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Decreasing Patient Radiation Dose from CT Imaging Achieving Sub mSv Studies (U01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-12-206.
Which agency is sponsoring this funding announcement?
The sponsoring agency is the National Institutes of Health (NIH).
What is the main purpose of PAR-12-206?
The FOA is intended to stimulate research that substantially reduces the radiation dose patients receive from computed tomography (CT) imaging while preserving the image quality and diagnostic confidence that make CT clinically valuable.
What specific dose target is NIH aiming for in this program?
The stated goal is to enable routine CT exams to be performed at patient radiation exposures below 1 millisievert (sub-mSv).
Why is reducing CT radiation dose an NIH priority in this announcement?
CT uses ionizing radiation, and cumulative exposure over a lifetime can increase the potential risk of radiation-related harms, including increased lifetime cancer risk. This FOA emphasizes shifting the risk-benefit balance by reducing the radiation component while maintaining diagnostic benefit.
Does the FOA focus on incremental improvements or major changes in practice?
The FOA signals interest in outcomes that could change standard practice by enabling very-low-dose (sub-1 mSv) CT in routine clinical scanning, rather than only modest or incremental dose reductions.
What funding mechanism is used for this opportunity?
This opportunity uses the U01 Cooperative Agreement mechanism.
What does it mean that this is a U01 Cooperative Agreement?
A cooperative agreement typically involves substantial NIH programmatic involvement during the project period. Awardees generally conduct the research while coordinating closely with NIH staff on milestones, progress, and program priorities.
What is the funding activity category for this FOA?
The funding activity category is Health.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.286, identified as "Discovery and Applied Research for Technological Innovations to Improve Human Health."
Is cost sharing or matching required?
No cost sharing or matching requirement is stated for applicants.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and public entities, including:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits with 501(c)(3) status (and other than institutions of higher education)
- Nonprofits without 501(c)(3) status (and other than institutions of higher education)
- Small businesses
- For-profit organizations other than small businesses
Are certain institution types specifically called out as eligible?
Yes. The FOA specifically calls out additional eligible groups, including:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Alaska Native and Native Hawaiian Serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Faith-based or community-based organizations
- Regional organizations
- Eligible federal agencies
- U.S. territories or possessions
- Certain tribal governments (including federally recognized tribes and other Indian/Native American tribal governments)
Are foreign institutions eligible to apply?
No. Foreign institutions (non-U.S. entities) are not eligible to apply.
Are foreign components allowed under this FOA?
No. Foreign components, as defined by the NIH Grants Policy Statement, are not allowed.
Can a U.S. organization include non-U.S. work or sites in any way?
Yes, the FOA notes that non-domestic components of U.S. organizations are eligible. This can matter for multi-site efforts where part of the work or data involves non-U.S. facilities that are part of a U.S. applicant organization.
When was this opportunity posted?
The opportunity was posted on June 13, 2012.
What was the closing date for applications?
The closing date listed is September 11, 2014.
Is this FOA still accepting applications?
No. The FOA has an archive date of October 12, 2014, and is no longer accepting applications.
Where can applicants or researchers view the full announcement?
The full announcement is referenced at: http://grants.nih.gov/grants/guide/pa-files/PAR-12-206.html
Who should be contacted for access or technical issues with the announcement?
For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
How should this FOA be understood at a high level?
It is a targeted NIH effort to accelerate research and development that makes very-low-dose CT clinically routine, emphasizing solutions that reduce patient radiation exposure while preserving the diagnostic strengths of CT, with a clear performance destination of sub-1 mSv patient doses in everyday scanning.
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