Opportunity Information: Apply for PA 12 210
Apply for PA 12 210
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Renal Function and Chronic Kidney Disease in Aging (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jun 13, 2012 and posted on Jun 13, 2012.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Private institutions of higher education Special district governments State governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) County governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Renal Function and Chronic Kidney Disease in Aging (R21) opportunity (Funding Opportunity Number PA 12-210) is a National Institutes of Health grant program issued by the National Institute on Aging (NIA) to support research that improves how chronic kidney disease (CKD) is understood, detected, and managed in the context of aging. The program is aimed at basic, clinical, and translational projects that can clarify why kidney function declines with age for some people, how CKD develops and progresses in older adults, and what the downstream consequences of CKD look like in later life. The overall intent is to build a stronger evidence base that can guide real-world decisions about diagnosis, prevention, and treatment of CKD specifically in older persons, where comorbidities, frailty, polypharmacy, and age-related physiological changes often complicate standard approaches.
The FOA highlights four broad research directions that applicants are expected to align with. First, it encourages work on the biology and pathophysiology of CKD in animal models, which can include mechanistic studies of kidney aging, cellular and molecular drivers of fibrosis or inflammation, vascular and metabolic contributors, and how systemic aging processes interact with renal function. Second, it calls for studies on the etiology and pathophysiology of CKD in older adults, including clinical and translational investigations that examine how CKD presents in late life, how progression differs from younger populations, and how aging-related changes in muscle mass, nutrition, or immune function may affect kidney biomarkers and disease trajectories. Third, it supports epidemiology and risk factor research focused on how CKD emerges with advancing age, which can involve population-level analyses of incidence and prevalence patterns, life-course risk exposures, health disparities, genetic and environmental contributions, and identification of modifiable factors that could reduce risk or slow decline. Fourth, it prioritizes research on diagnosis, medical management, and clinical outcomes, including improving diagnostic strategies for older adults, evaluating treatment approaches and care models, assessing benefits and harms of interventions in this age group, and studying outcomes that matter in geriatrics such as functional status, cognition, cardiovascular events, hospitalization, quality of life, and mortality.
This announcement uses the NIH R21 mechanism, which is generally intended for exploratory and developmental research that can generate early evidence, feasibility data, or proof-of-concept findings that may later support larger studies. The listed award ceiling is $200,000, and the opportunity is categorized as discretionary funding in the health area under CFDA 93.866 (Aging Research). Cost sharing or matching is not required, which means applicants are not expected to contribute non-federal funds as a condition of receiving an award.
Eligibility is broad and includes many organization types across academia, government, nonprofit, and industry. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations other than small businesses, and small businesses. Government entities at multiple levels are also eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes a range of mission-focused and underserved-serving organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and tribal organizations and governments (including federally recognized tribal governments and other tribal entities). Faith-based and community-based organizations, regional organizations, and eligible federal agencies are included as well. Importantly, non-U.S. entities (foreign institutions) may apply, and non-U.S. components of U.S. organizations are eligible; foreign components are allowed consistent with the NIH Grants Policy Statement.
Administratively, the FOA was posted on June 13, 2012, with an original and current closing date of January 7, 2016, and an archive date of February 7, 2016, indicating it is no longer active as a current competition but remains part of the historical NIH funding opportunity record. The sponsoring agency is NIH (NIA), and the full announcement was hosted through the NIH Grants Guide. For technical access issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV), which is intended for troubleshooting access or linking problems rather than scientific questions about project fit.
In practical terms, this grant announcement was designed to stimulate a pipeline of aging-focused CKD research spanning lab mechanisms, patient-oriented pathophysiology, population risk characterization, and clinical management questions, all centered on older adults. The expected payoff is stronger scientific clarity about how CKD intersects with aging and better evidence to support clinicians and health systems in preventing kidney decline, improving diagnostic accuracy, and optimizing treatment decisions for older people living with or at risk for CKD.
Frequently Asked Questions (FAQs)
What is the "Renal Function and Chronic Kidney Disease in Aging (R21)" opportunity?
It is a National Institutes of Health (NIH) grant opportunity (Funding Opportunity Number PA 12-210) issued by the National Institute on Aging (NIA). It supports research to improve how chronic kidney disease (CKD) is understood, detected, and managed specifically in the context of aging.
What is the main purpose or intent of this FOA?
The intent is to strengthen the evidence base that informs real-world decisions about diagnosis, prevention, and treatment of CKD in older adults. The FOA emphasizes that standard approaches can be complicated in later life due to comorbidities, frailty, polypharmacy, and age-related physiological changes.
What types of research projects does this program support?
The FOA is aimed at basic, clinical, and translational research projects. It is designed to support studies that clarify why kidney function declines with age for some people, how CKD develops and progresses in older adults, and what the downstream consequences look like in later life.
Who is the target population or focus area for the research?
The focus is CKD and renal function in aging, with an emphasis on older adults and late-life outcomes. The research is expected to be grounded in aging-related considerations that affect kidney disease presentation, progression, diagnosis, and management.
What are the four broad research directions highlighted in the FOA?
The FOA highlights four broad directions applicants are expected to align with:
- Biology and pathophysiology of CKD in animal models (e.g., mechanistic studies of kidney aging; cellular and molecular drivers of fibrosis or inflammation; vascular and metabolic contributors; interactions between systemic aging processes and renal function).
- Etiology and pathophysiology of CKD in older adults (e.g., clinical/translational studies on late-life presentation; how progression differs from younger populations; how aging-related changes in muscle mass, nutrition, or immune function affect biomarkers and trajectories).
- Epidemiology and risk factor research (e.g., incidence and prevalence patterns with advancing age; life-course exposures; health disparities; genetic and environmental contributions; identification of modifiable factors to reduce risk or slow decline).
- Diagnosis, medical management, and clinical outcomes (e.g., improved diagnostic strategies for older adults; evaluating treatment approaches and care models; benefits and harms in this age group; outcomes relevant to geriatrics such as functional status, cognition, cardiovascular events, hospitalization, quality of life, and mortality).
What is the NIH R21 mechanism and what does it imply for project scope?
This FOA uses the NIH R21 mechanism, which is generally intended for exploratory and developmental research. It is often used to generate early evidence, feasibility data, or proof-of-concept findings that could support later, larger studies.
What is the maximum award amount listed for this opportunity?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required, meaning applicants are not expected to contribute non-federal funds as a condition of receiving an award.
What is the funding classification and program area?
The opportunity is categorized as discretionary funding in the health area under CFDA 93.866 (Aging Research).
Which NIH Institute is sponsoring this FOA?
The sponsoring agency is NIH, and the issuing Institute for this FOA is the National Institute on Aging (NIA).
When was this FOA posted and is it still active?
The FOA was posted on June 13, 2012. It lists an original and current closing date of January 7, 2016, and an archive date of February 7, 2016. Based on these dates, it is no longer active as a current competition and is part of the historical NIH funding opportunity record.
Where was the full announcement hosted?
The full announcement was hosted through the NIH Grants Guide.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes organizations across academia, government, nonprofit, and industry, including:
- Public and private institutions of higher education
- Nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education)
- For-profit organizations other than small businesses
- Small businesses
- State, county, city or township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Eligible federal agencies
- Regional organizations
- Faith-based and community-based organizations
Are minority-serving and tribal-serving institutions explicitly included?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and tribal organizations and governments (including federally recognized tribal governments and other tribal entities).
Can non-U.S. (foreign) organizations apply?
Yes. Non-U.S. entities (foreign institutions) may apply, and non-U.S. components of U.S. organizations are eligible. Foreign components are allowed consistent with the NIH Grants Policy Statement.
Does the FOA say anything about outcomes that matter for older adults?
Yes. In the diagnosis/management/outcomes direction, it prioritizes outcomes that matter in geriatrics, including functional status, cognition, cardiovascular events, hospitalization, quality of life, and mortality.
What kinds of aging-related complications does the FOA highlight for CKD care in older adults?
It highlights that comorbidities, frailty, polypharmacy, and age-related physiological changes can complicate standard approaches to CKD diagnosis and treatment in older persons.
What kinds of questions might be a fit under the animal model research direction?
Examples mentioned include mechanistic studies of kidney aging, cellular and molecular drivers of fibrosis or inflammation, vascular and metabolic contributors, and research on how systemic aging processes interact with renal function.
What kinds of questions might be a fit under the clinical/translational direction in older adults?
Examples include examining how CKD presents in late life, how progression differs from younger populations, and how aging-related changes (such as muscle mass, nutrition, or immune function) may affect kidney biomarkers and disease trajectories.
What kinds of studies might be a fit under the epidemiology and risk factor direction?
Examples include population-level analyses of incidence and prevalence with advancing age, study of life-course risk exposures, health disparities, genetic and environmental contributors, and identification of modifiable factors that could reduce risk or slow decline.
What kinds of topics might be a fit under the diagnosis/management/outcomes direction?
Examples include improving diagnostic strategies for older adults, evaluating treatment approaches and care models, assessing benefits and harms of interventions in this age group, and studying outcomes relevant to late-life health and functioning.
Who should be contacted for technical access or linking issues with the announcement?
For technical access issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. The FOA notes this is for troubleshooting access or linking problems rather than scientific questions about project fit.
What is the expected payoff of the research supported by this FOA?
The FOA describes an expected payoff of stronger scientific clarity about how CKD intersects with aging, and better evidence to support clinicians and health systems in preventing kidney decline, improving diagnostic accuracy, and optimizing treatment decisions for older people living with or at risk for CKD.
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