Opportunity Information: Apply for RFA AI 12 042
Apply for RFA AI 12 042
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Delivering Therapeutics to Residual Active HIV Reservoirs (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jan 15, 2013 and posted on Jan 15, 2013.
- Applicants must submit their applications by Jul 24, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education State governments Public housing authorities/Indian housing authorities Special district governments Independent school districts County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NIH funding opportunity "Delivering Therapeutics to Residual Active HIV Reservoirs (R01)" (Funding Opportunity Number RFA-AI-12-042) is a discretionary grant announcement that supports research projects aimed at a specific and persistent barrier to curing HIV: cellular reservoirs that continue producing virus in tissue compartments even when standard antiretroviral therapy has successfully suppressed HIV levels in the blood (plasma viremia). In practical terms, the FOA is focused on the problem that a person can look fully suppressed on routine blood tests while HIV is still active in certain tissues and cell populations, sustaining inflammation, ongoing infection risk at the tissue level, and long-term persistence of the virus.
The central scientific goal is to generate and test new ideas for eliminating, disabling, or clearing these residual active HIV reservoirs by improving how therapeutics reach the right places and the right cells. The announcement emphasizes that conventional systemic dosing may not adequately penetrate certain anatomical sites or may not effectively target the specific cell types that harbor or produce HIV in these compartments. As a result, the FOA encourages strategies that enhance delivery of antiretrovirals or other anti-HIV agents to tissues where active reservoirs persist, or that enable more precise targeting of relevant cell populations. The intended impact is multi-part: to block continued virus production and new infection events within tissues, to reduce HIV-associated inflammation driven by ongoing local viral activity, and to facilitate clearance of the reservoir cells that sustain infection despite otherwise effective treatment.
Administratively, this opportunity uses the NIH R01 mechanism, indicating support for investigator-initiated, hypothesis-driven research projects at a scale typical for mature, multi-year biomedical studies. The activity category is Health, and the opportunity is associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research), 93.856 (Microbiology and Infectious Diseases Research), and it is also cross-referenced with 93.242 (Mental Health Research Grants), reflecting NIH cataloging rather than a requirement that projects address mental health. There is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of award.
The eligible applicant pool is broad and includes many types of U.S. organizations and governments as well as non-U.S. entities. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations (other than small businesses), state and local governments (including counties, cities or townships, special district governments, and independent school districts), public housing authorities/Indian housing authorities, and federally recognized Native American tribal governments as well as other tribal organizations. The FOA also explicitly notes eligibility for a wide range of mission-driven or capacity-building institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs), along with faith-based and community-based organizations and eligible federal agencies. Importantly, foreign organizations and foreign institutions are eligible to apply, and non-U.S. components of U.S. organizations are also eligible; foreign components are allowed as defined by the NIH Grants Policy Statement. This openness signals an interest in drawing on global expertise, infrastructure, and tissue-compartment research that may be best supported through international collaborations.
Key dates indicate this was posted and created on January 15, 2013, with an original and current closing date of July 24, 2013, and an archive date of August 24, 2013. The sponsoring agency is the National Institutes of Health, and the full announcement was hosted on the NIH grants site. For technical issues accessing the posting, the listed support contact is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV), which is a standard point of contact for electronic access and linking problems rather than programmatic questions.
Overall, the FOA can be understood as a call for innovative delivery-focused HIV cure research: not simply developing new drugs, but solving the biological and pharmacologic problem of getting effective antiretroviral or anti-HIV interventions into hard-to-reach tissue reservoirs and into the exact cell types that remain active sources of virus during otherwise successful therapy, with the broader aim of reducing ongoing viral activity, limiting inflammation, and enabling elimination of the reservoir cells that maintain HIV persistence.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Delivering Therapeutics to Residual Active HIV Reservoirs (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AI-12-042.
What type of award mechanism does this opportunity use?
This opportunity uses the NIH R01 mechanism, which supports investigator-initiated, hypothesis-driven research projects typically conducted over multiple years.
What problem is this FOA trying to address in HIV research?
It targets a key barrier to curing HIV: residual active cellular reservoirs that can keep producing virus in tissue compartments even when standard antiretroviral therapy has suppressed HIV levels in the blood (plasma viremia).
What does "residual active HIV reservoirs" mean in practical terms?
It refers to situations where routine blood tests show HIV is fully suppressed, but HIV remains active in certain tissues and cell populations. This ongoing tissue-level activity can sustain inflammation and contribute to long-term persistence of the virus.
What is the central scientific goal of the FOA?
The central goal is to generate and test new approaches to eliminate, disable, or clear residual active HIV reservoirs by improving how therapeutics reach the right anatomical sites and the right cell types where HIV remains active.
Is this FOA mainly about developing new drugs?
The FOA is framed as delivery-focused HIV cure research. It is not limited to inventing new drugs; it emphasizes solving the biological and pharmacologic problem of getting effective antiretroviral or other anti-HIV interventions into hard-to-reach tissue reservoirs and into the specific cell types that remain active sources of virus during otherwise successful therapy.
Why is therapeutic delivery a major focus here?
The announcement highlights that conventional systemic dosing may not adequately penetrate certain anatomical sites and may not effectively target the specific cell types that harbor or produce HIV in these compartments. Improving delivery is positioned as a key step toward blocking ongoing virus production and enabling reservoir clearance.
What kinds of strategies does the FOA encourage?
It encourages strategies that enhance delivery of antiretrovirals or other anti-HIV agents to tissues where active reservoirs persist, or that enable more precise targeting of the relevant cell populations within those tissues.
What outcomes or impacts is NIH aiming for through this research?
The intended impact includes: blocking continued virus production and new infection events within tissues, reducing HIV-associated inflammation driven by ongoing local viral activity, and facilitating clearance of the reservoir cells that sustain infection despite otherwise effective treatment.
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What is the activity category for this opportunity?
The activity category is Health.
Which CFDA numbers are associated with this FOA?
The opportunity is associated with CFDA 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), and it is also cross-referenced with 93.242 (Mental Health Research Grants).
Does the CFDA 93.242 cross-reference mean proposals must address mental health?
No. The cross-reference is described as NIH cataloging rather than a requirement that projects address mental health.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, so applicants are not required to provide non-federal matching funds as a condition of award.
Who is eligible to apply?
Eligibility is broad and includes many U.S. organizations and governments as well as non-U.S. entities. Eligible applicants include public and private institutions of higher education; nonprofits with or without 501(c)(3) status; small businesses; for-profit organizations (other than small businesses); and a variety of government entities (state, local, county, city/township, special district, and independent school districts), plus public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible, and the FOA also includes other tribal organizations as eligible applicants.
Are specific institution types like HBCUs, HSIs, and TCCUs eligible?
Yes. The FOA explicitly notes eligibility for institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs).
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are included in the eligible applicant pool.
Can federal agencies apply?
Yes. The FOA notes that eligible federal agencies may apply.
Are foreign organizations allowed to apply?
Yes. Foreign organizations and foreign institutions are eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. Non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by the NIH Grants Policy Statement.
What does the FOA suggest about international collaboration?
By allowing foreign organizations and foreign components, the FOA signals an interest in drawing on global expertise and infrastructure, including tissue-compartment research that may be well supported through international collaborations.
When was this FOA posted?
It was posted (and created) on January 15, 2013.
What was the closing date for applications?
The original and current closing date listed is July 24, 2013.
When was the FOA archived?
The archive date is August 24, 2013.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants website.
Who should be contacted for technical issues accessing the posting?
For technical issues related to accessing the posting, the listed support contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Is the listed contact meant for programmatic or scientific questions?
The listed contact is described as a standard point of contact for electronic access and linking problems rather than programmatic questions.
Browse more opportunities from the same category: Health
Next opportunity: Innovation for HIV Vaccine Discovery (R01)
Previous opportunity: BJA FY 13 Enhanced Collaborative Model to Combat Human Trafficking
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA AI 12 042
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA AI 12 042) also looked into and applied for these:
| Funding Opportunity |
|---|
| Innovation for HIV Vaccine Discovery (R01) Apply for RFA AI 13 007 Funding Number: RFA AI 13 007 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Technical assistance in support of clinical training and mentoring for HIV treatment and prevention services in the Republic of Zimbabwe under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1329 Funding Number: CDC RFA GH13 1329 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $6,900,000 |
| Scaling up Voluntary Medical Male Circumcision through improvements in the availability, integration and quality of HIV prevention, care and treatment services in Zimbabwe under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1328 Funding Number: CDC RFA GH13 1328 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $12,000,000 |
| Support Services from the World Health Organization (WHO) for the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1327 Funding Number: CDC RFA GH13 1327 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $15,000,000 |
| Autoimmunity Centers of Excellence, Basic Research Program (U19) Apply for RFA AI 12 060 Funding Number: RFA AI 12 060 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Autoimmunity Centers of Excellence, Clinical Research Program (UM1) Apply for RFA AI 12 059 Funding Number: RFA AI 12 059 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Family Planning and Reproductive Health Methods APS Apply for SOL OAA 13 000024 Funding Number: SOL OAA 13 000024 Agency: Agency for International Development Category: Health Funding Amount: $80,000,000 |
| Statewide Consumer Network Grant Apply for SM 13 004 Funding Number: SM 13 004 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $70,000 |
| Implementing Public Health Programs and Strengthening Public Health Capacity in Guatemala and Central American Apply for CDC RFA GH13 1306 Funding Number: CDC RFA GH13 1306 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $4,000,000 |
| Engaging Parents in Prevention of Child Sexual Abuse and Sexual Risk Behaviors Targeting Youth Scaling up the Implementation of Families Matter in the United Republic of Tanzania under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1324 Funding Number: CDC RFA GH13 1324 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,200,000 |
| Clinical Neuroscience and Entertainment Software Pilot Partnership Program to Develop Neuropsychiatric Interventions (R43/R44) Apply for RFA MH 14 010 Funding Number: RFA MH 14 010 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01) Apply for RFA AG 13 018 Funding Number: RFA AG 13 018 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIMHD Minority Health and Health Disparities International Research Training (T37) Apply for RFA MD 13 002 Funding Number: RFA MD 13 002 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Biodynamics Grant Opportunity Apply for 13 01 Funding Number: 13 01 Agency: DOT FAA Aviation Research Grants Category: Health Funding Amount: $750,000 |
| Small Rural Hospital Improvement Grant Program (SHIP) Apply for HRSA 13 163 Funding Number: HRSA 13 163 Agency: Health Resources and Services Administration Category: Health Funding Amount: $9,000 |
| New Access Point Grants Apply for HRSA 13 228 Funding Number: HRSA 13 228 Agency: Health Resources and Services Administration Category: Health Funding Amount: $650,000 |
| Saving Lives at Birth A Grand Challenge for Development (Round 3) Apply for RFA OAA 13 000004 Funding Number: RFA OAA 13 000004 Agency: Agency for International Development Category: Health Funding Amount: Case Dependent |
| Strengthen Brazils National Response to HIV and other diseases through innovative and evidence based approaches in laboratory, strategic information, prevention and care activities and foster partnerships between Brazil, Angola and Mozambique (PEPFAR Apply for CDC RFA GH13 1343 Funding Number: CDC RFA GH13 1343 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $3,500,000 |
| Tanzanian Ministry of Health and Social Welfare System Strengthening for Enhanced Evidence Based Decision Making and Management and Delivery of Quality Health Services in the United Republic of Tanzania under the Presidents Emergency Plan for AIDS Re Apply for CDC RFA GH13 1319 Funding Number: CDC RFA GH13 1319 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $2,000,000 |
| Rural Training Track Technical Assistance Demonstration Program Apply for HRSA 13 247 Funding Number: HRSA 13 247 Agency: Health Resources and Services Administration Category: Health Funding Amount: $300,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA AI 12 042", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.