Opportunity Information: Apply for RFA AI 13 007
Apply for RFA AI 13 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Innovation for HIV Vaccine Discovery (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jan 15, 2013 and posted on Jan 15, 2013.
- Applicants must submit their applications by Jul 24, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,050,000.00 to eligible and selected applicants.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Special district governments Public housing authorities/Indian housing authorities County governments Private institutions of higher education City or township governments For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Innovation for HIV Vaccine Discovery (R01) opportunity (Funding Opportunity Number RFA-AI-13-007) is a National Institutes of Health (NIH) research grant designed to push early-stage HIV vaccine science in bold new directions. The central goal is to support innovative, high-risk, high-impact projects that identify fresh vaccine concepts, new biological targets, or unconventional strategies that could ultimately help researchers design an effective HIV immunogen. In practical terms, NIH is looking for discovery research that can open up new ways to think about HIV vaccination, especially ideas that could reshape how immunogens are designed or how immunization regimens are constructed to provide long-term protection against HIV acquisition.
A key feature of this FOA is its deliberate emphasis on creativity and “outside-the-box†thinking rather than incremental development. The announcement highlights early discovery work, meaning projects are expected to focus on identifying and validating novel concepts and targets, generating compelling proof-of-principle data, and establishing a scientific foundation that could later support more advanced vaccine development. The intent is to broaden the pipeline of HIV vaccine ideas by bringing in approaches that may not fit neatly within standard vaccine development pathways, while still aiming for clear relevance to eventual protective vaccination.
The program is explicitly open to both established investigators and newer researchers, and it does not require applicants to already have a background in HIV prevention research. That detail matters because it signals an effort to attract talent and methods from other fields, for example immunology, structural biology, systems biology, computational modeling, protein engineering, microbiology, or novel platform technologies, and apply them to HIV vaccine discovery. The FOA is structured to encourage cross-disciplinary entries where the innovation itself is the primary value, even if the team is relatively new to HIV.
Administratively, this is a discretionary grant using the NIH R01 funding instrument, categorized under the health activity area. It is associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). The opportunity does not require cost sharing or matching funds, which reduces the financial barrier for applicants and helps keep the focus on scientific merit and innovation.
Eligibility is broad and includes a wide range of U.S. and non-U.S. organizations. Domestic eligible applicants listed include nonprofit organizations (with or without 501(c)(3) status), public and private institutions of higher education, state and local governments (including county and city/township governments), special district governments, independent school districts, public housing authorities/Indian housing authorities, tribal governments and tribal organizations (including federally recognized tribes and other tribal entities), and for-profit organizations (including small businesses and other for-profits). The FOA also makes clear that non-domestic entities are eligible: foreign organizations and foreign institutions may apply, non-domestic components of U.S. organizations may apply, and foreign components (as defined by the NIH Grants Policy Statement) are allowed. It additionally calls out categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, AANAPISIs, faith-based or community-based organizations, U.S. territories or possessions, and eligible federal agencies, reinforcing the intent to attract a diverse applicant pool.
From a timeline standpoint, the FOA was posted and created on January 15, 2013, with an original and current closing date of July 24, 2013, and an archive date of August 24, 2013. The estimated total funding amount listed is $3,050,000, indicating NIH planned a modest but meaningful investment aimed at seeding multiple innovative projects rather than funding a single large program.
For applicants who need the full official text and requirements, the FOA points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-13-007.html. Contact support is directed to the NIH Office of Extramural Research (OER) Webmaster for technical access or linking issues via FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the Innovation for HIV Vaccine Discovery (R01) opportunity?
The Innovation for HIV Vaccine Discovery (R01) is an NIH research grant opportunity focused on advancing early-stage HIV vaccine science in bold new directions. It is designed to support discovery research that identifies fresh vaccine concepts, new biological targets, or unconventional strategies that could ultimately contribute to designing an effective HIV immunogen.
What is the Funding Opportunity Number (FOA) for this grant?
The Funding Opportunity Number is RFA-AI-13-007.
What is the main goal of this funding opportunity?
The central goal is to support innovative, high-risk, high-impact discovery projects that can open new ways of thinking about HIV vaccination, particularly approaches that could reshape immunogen design or how immunization regimens are constructed for long-term protection against HIV acquisition.
What types of projects is NIH looking to fund under this FOA?
NIH is looking for discovery research that emphasizes creativity and outside-the-box thinking rather than incremental development. Projects are expected to focus on identifying and validating novel concepts and targets, generating compelling proof-of-principle data, and establishing a scientific foundation that could later support more advanced vaccine development.
Is this opportunity focused on early-stage research or later-stage vaccine development?
This FOA emphasizes early discovery work. The intent is to seed innovative ideas and generate proof-of-principle evidence that could later enable more advanced HIV vaccine development efforts.
Does an applicant need prior HIV prevention research experience to apply?
No. The program is explicitly open to investigators who may be new to HIV prevention research. This is intended to attract talent, tools, and perspectives from other scientific fields and apply them to HIV vaccine discovery.
Who can apply: established investigators, early-career researchers, or both?
Both established investigators and newer researchers are eligible to apply.
What kinds of disciplines or approaches does this FOA encourage?
The FOA encourages cross-disciplinary approaches and seeks innovation as the primary value. It specifically signals interest in bringing in methods from areas such as immunology, structural biology, systems biology, computational modeling, protein engineering, microbiology, and novel platform technologies, among others, as long as they are relevant to HIV vaccine discovery.
What funding mechanism does this program use?
This opportunity uses the NIH R01 research grant funding instrument.
Is this a discretionary grant?
Yes. The FOA describes it as a discretionary grant using the NIH R01 funding instrument.
What health activity area is associated with this opportunity?
The opportunity is categorized under the health activity area.
What CFDA numbers are associated with this FOA?
The FOA is associated with CFDA 93.855 (Allergy and Infectious Diseases Research) and CFDA 93.856 (Microbiology and Infectious Diseases Research).
Does this grant require cost sharing or matching funds?
No. The opportunity does not require cost sharing or matching funds.
Which organizations are eligible to apply?
Eligibility is broad and includes domestic and non-domestic entities. Domestic eligibility includes nonprofit organizations (with or without 501(c)(3) status), public and private institutions of higher education, state and local governments (including county and city/township governments), special district governments, independent school districts, public housing authorities/Indian housing authorities, tribal governments and tribal organizations, and for-profit organizations (including small businesses and other for-profits).
Are for-profit organizations allowed to apply?
Yes. For-profit organizations, including small businesses and other for-profit entities, are listed as eligible applicants.
Are foreign organizations eligible to apply?
Yes. The FOA states that foreign organizations and foreign institutions may apply. It also allows non-domestic components of U.S. organizations to apply, and foreign components (as defined by the NIH Grants Policy Statement) are allowed.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations (including federally recognized tribes and other tribal entities) are included in the eligible applicant categories.
Does the FOA encourage applications from diverse institution types?
Yes. The FOA calls out a range of institution categories, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, AANAPISIs, faith-based or community-based organizations, U.S. territories or possessions, and eligible federal agencies.
What is the total estimated funding amount for this opportunity?
The estimated total funding amount listed is $3,050,000.
When was this FOA posted and created?
The FOA was posted and created on January 15, 2013.
What was the application closing date?
The original and current closing date listed is July 24, 2013.
When was the opportunity archived?
The archive date listed is August 24, 2013.
Where can applicants find the official FOA text and full requirements?
The FOA directs applicants to the NIH Grants Guide page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-13-007.html.
Who should be contacted for technical access or linking issues related to the FOA?
Technical access or linking issues are directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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