Opportunity Information: Apply for RFA AG 12 011
Apply for RFA AG 12 011
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Demonstration Projects for Systems Biology of Aging in Saccharomyces cerevisiae (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Aug 5, 2011 and posted on Aug 5, 2011.
- Applicants must submit their applications by Nov 4, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $800,000.00 to eligible and selected applicants.
- Eligible applicants include: Private institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education State governments Native American tribal governments (Federally recognized) Independent school districts City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public housing authorities/Indian housing authorities Small businesses Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institute on Aging (NIA), part of the National Institutes of Health (NIH), offered this grant opportunity to support demonstration-style research projects testing whether systems-level approaches can uncover new, meaningful insights into the molecular mechanisms of aging. The focus organism is Saccharomyces cerevisiae (baker's yeast), a single-celled model that has a long track record in aging research because it is genetically tractable, inexpensive to work with at scale, and well suited to both classic molecular genetics and modern high-throughput biology. The central idea behind the announcement is to push beyond studying individual genes or pathways in isolation and instead evaluate whether integrating data across biological layers (for example, genome, transcriptome, proteome, metabolome, and cellular phenotypes) can reveal emergent properties of aging that are not obvious from reductionist experiments alone.
This opportunity was structured as an R01 research project grant, meaning it was intended for substantial, hypothesis-driven projects rather than small pilot studies, but with a strong emphasis on "demonstration" value: applicants were expected to show, in a clear and convincing way, that systems biology methods can actually change what we learn about aging biology in yeast. In practice, that implies projects that generate or integrate large-scale datasets, build predictive or explanatory models, and connect those models back to experimentally testable mechanisms. While the summary does not list specific required methods, the wording signals interest in comprehensive analyses such as network modeling, multi-omics integration, quantitative and computational approaches, and experimental designs that can validate systems-level predictions in vivo within yeast aging paradigms.
Administratively, the announcement was listed as a discretionary grant program within the health funding activity category and mapped to CFDA number 93.866 (Aging Research). There was no cost sharing or matching requirement. The posting date and creation date were both August 5, 2011, with an original and final application due date of November 4, 2011, and the program archive date was December 5, 2011, indicating the opportunity is historical and no longer open. The estimated total funding listed was $800,000, which likely reflected the approximate amount NIA planned to commit to awards under this specific solicitation for that cycle.
Eligibility was broad and included many categories of U.S.-based organizations that commonly participate in NIH funding. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a variety of government entities such as state governments, county governments, city or township governments, special district governments, and independent school districts. The eligibility language also explicitly included tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments), public housing authorities/Indian housing authorities, and regional organizations. Additional eligible groups named included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, and U.S. territories or possessions. This broad eligibility reflects NIH's general openness to strong scientific proposals regardless of institutional type, as long as the applicant can carry out the required research.
For applicants seeking the full official terms, the announcement referenced an NIH grants page hosting the complete solicitation under Funding Opportunity Number RFA-AG-12-011, titled "Demonstration Projects for Systems Biology of Aging in Saccharomyces cerevisiae (R01)." The contact information provided was oriented toward technical access issues (for example, difficulties accessing or linking to the announcement) through the NIH Office of Extramural Research (OER) webmaster email address, rather than a dedicated scientific or grants management contact listed in the excerpt.
Frequently Asked Questions (FAQs)
What is this grant opportunity?
This was a National Institute on Aging (NIA), National Institutes of Health (NIH) grant opportunity for research projects titled "Demonstration Projects for Systems Biology of Aging in Saccharomyces cerevisiae (R01)." The Funding Opportunity Number referenced is RFA-AG-12-011.
Which NIH institute offered the opportunity?
The opportunity was offered by the National Institute on Aging (NIA), which is part of the National Institutes of Health (NIH).
What type of award mechanism was used?
The announcement was structured as an NIH R01 research project grant. That mechanism is generally used for substantial, hypothesis-driven research projects (not small pilot studies), and in this case it also emphasized strong "demonstration" value.
What was the main scientific goal of the program?
The goal was to support demonstration-style research testing whether systems-level approaches can uncover new, meaningful insights into the molecular mechanisms of aging. The intent was to move beyond studying individual genes or pathways in isolation and instead integrate information across multiple biological layers to identify emergent properties of aging.
What organism was the focus of the research?
The focus organism was Saccharomyces cerevisiae (baker's yeast), a single-celled model organism widely used in aging research.
Why was baker's yeast (Saccharomyces cerevisiae) selected for this aging research program?
Based on the description, yeast was emphasized because it is genetically tractable, inexpensive to work with at scale, and well suited for both classic molecular genetics and modern high-throughput biology. It also has a long track record as a model in aging research.
What does "systems biology of aging" mean in the context of this opportunity?
In this context, systems biology refers to approaches that integrate data across multiple biological layers (for example, genome, transcriptome, proteome, metabolome, and cellular phenotypes) to build models and uncover relationships that may not be apparent from reductionist, single-gene or single-pathway studies.
What kinds of data integration were implied or encouraged?
The summary specifically points to integrating information across biological layers such as the genome, transcriptome, proteome, metabolome, and cellular phenotypes. The overall emphasis suggests projects that either generate large-scale datasets, integrate existing and new datasets, or both.
What kinds of methods were signaled as relevant to competitive projects?
While the excerpt does not list required methods, it signals interest in comprehensive systems-level analyses, such as network modeling, multi-omics integration, quantitative and computational approaches, and experimental designs that can validate systems-level predictions in vivo within yeast aging paradigms.
What does "demonstration" mean for this R01?
The emphasis on "demonstration" meant applicants were expected to show clearly and convincingly that systems biology approaches can change what is learned about aging biology in yeast. In practice, that implies building predictive or explanatory models and then connecting those models back to experimentally testable mechanisms.
Was this opportunity focused on small pilot projects or larger hypothesis-driven projects?
It was positioned as an R01 program intended for substantial, hypothesis-driven projects, rather than small pilot studies, with an added requirement that the work demonstrate the value of systems approaches for aging biology in yeast.
What was the funding activity category and CFDA number?
The program was listed as a discretionary grant program in the health funding activity category, and it was mapped to CFDA number 93.866 (Aging Research).
How much total funding was estimated for this solicitation?
The estimated total funding listed was $800,000, described as the approximate amount NIA planned to commit to awards under this specific solicitation for that cycle.
Was cost sharing or matching required?
No. The announcement stated there was no cost sharing or matching requirement.
When was the opportunity posted?
The posting date and creation date were both August 5, 2011.
What were the application due dates?
The original application due date and the final application due date were both November 4, 2011.
Is this funding opportunity still open?
No. The program archive date was December 5, 2011, and the provided timeline indicates the opportunity is historical and no longer open.
Who was eligible to apply?
Eligibility was broad and included many U.S.-based organization types commonly eligible for NIH funding. The excerpt lists public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other for-profits); and multiple government entities (state, county, city or township, special district governments, and independent school districts).
Were tribal governments and tribal organizations eligible?
Yes. The eligibility language explicitly included tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments).
Were U.S. territories or possessions eligible?
Yes. The eligibility list explicitly included U.S. territories or possessions.
Were minority-serving institutions explicitly included in the eligibility language?
Yes. The excerpt explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Were faith-based or community-based organizations eligible?
Yes. The eligibility language explicitly included faith-based or community-based organizations.
Were federal agencies eligible to apply?
Yes. The eligibility list included eligible agencies of the federal government.
Were public housing authorities eligible?
Yes. The eligibility language included public housing authorities/Indian housing authorities.
Were regional organizations eligible?
Yes. Regional organizations were explicitly listed as eligible applicants.
What was the central research strategy encouraged by the announcement?
The core strategy was to evaluate whether integrating multi-layer biological data and using systems-level modeling can produce insights into aging mechanisms that are not obvious from studying isolated genes or pathways, and then to connect those insights back to experimentally testable mechanisms in yeast.
Did the excerpt provide a dedicated scientific or grants management contact?
No. The contact information provided in the excerpt was oriented toward technical access issues (such as difficulties accessing or linking to the announcement) via the NIH Office of Extramural Research (OER) webmaster email address, rather than listing a dedicated scientific or grants management contact.
Where could applicants find the full official solicitation details?
The excerpt references an NIH grants page hosting the complete solicitation under Funding Opportunity Number RFA-AG-12-011, titled "Demonstration Projects for Systems Biology of Aging in Saccharomyces cerevisiae (R01)."
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