Opportunity Information: Apply for RFA NS 14 012
Apply for RFA NS 14 012
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Detect, Define and Measure the Progression of Chronic Traumatic Encephalopathy (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Jul 29, 2014 and posted on Jul 29, 2014.
- Applicants must submit their applications by Oct 31, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,300,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Independent school districts County governments City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments State governments Native American tribal governments (Federally recognized) Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NIH grant opportunity titled "Detect, Define and Measure the Progression of Chronic Traumatic Encephalopathy (U01)" (Funding Opportunity Number RFA-NS-14-012) is a discretionary research program offered through a cooperative agreement mechanism. Its core aim is to support a tightly coordinated, multi-year effort to identify and track signs of neurodegeneration in people who meet criteria for a probable or possible diagnosis of chronic traumatic encephalopathy (CTE). Rather than focusing on CTE only after death, the initiative emphasizes studying living individuals using brain imaging and other biological markers to improve how CTE is recognized, characterized, and monitored as it changes over time.
The scientific purpose centers on detecting, characterizing, and measuring disease progression over a longitudinal window of roughly three to five years. Applicants are expected to follow participants over time and generate evidence that links changes in imaging and biomarker measures to clinical changes, with the broader intent of clarifying underlying neurological mechanisms. In practical terms, the opportunity is designed to move the field toward better tools for in vivo detection and staging of CTE, addressing a major challenge in the area: the lack of widely accepted methods to diagnose and track CTE progression during life.
A major deliverable implied by the announcement is the development of a consensus diagnosis framework that can be used consistently across studies and, importantly, can serve as a foundation for future clinical trials. By establishing more reliable ways to identify who likely has CTE and how quickly it is progressing, the project is meant to set up the next generation of trials aimed at preventing CTE or slowing its neurodegenerative course. The cooperative agreement (U01) structure signals that NIH intends to be actively involved with the funded team, typically through substantial programmatic input, coordination expectations, milestones, and ongoing collaboration between the awardees and NIH staff. That mechanism is often used when a project requires standardized methods, shared protocols, or coordinated decision-making to produce results that the wider research community can adopt.
From a funding and administrative standpoint, the announcement anticipated a single award, with an estimated total funding level of about $2.3 million. There was no cost-sharing or matching requirement. The activity falls under the health category and the CFDA listing 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders), reflecting its alignment with NIH neuroscience priorities and neurological disease research.
Eligibility was broad and included many U.S.-based organizational types across government, academic, nonprofit, and business sectors. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (with the noted limitation that certain non-501(c)(3) nonprofits must not be institutions of higher education), small businesses, and other for-profit organizations (excluding small businesses where specified). Various governmental entities could apply, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Tribal governments and tribal organizations were also included, with coverage for federally recognized tribal governments as well as other tribal organizations, and tribally controlled colleges and universities.
The opportunity also explicitly recognized a range of mission-focused institutions and community-based entities as eligible, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs), along with faith-based or community-based organizations and eligible federal agencies. Non-U.S. organizations (foreign institutions) were not eligible to apply as the primary applicant, but the announcement allowed foreign components as defined in NIH policy, and it allowed non-domestic components of U.S. organizations to participate, which is a common NIH approach when specific expertise, assays, cohorts, or analytic capabilities may reside outside the United States while keeping the prime award domestically based.
Key dates indicate this was posted on July 29, 2014, with an original and current closing date of October 31, 2014, and an archive date of December 1, 2014. The sponsoring agency was the National Institutes of Health, and the full announcement was available through the NIH grants guide at the provided link. For access or technical issues, the contact point listed was the NIH Office of Extramural Research webmaster, reflecting that the main support channel for this posting was the standard NIH electronic announcement system rather than a scientific program contact listed in the excerpt provided.
Overall, the opportunity is best understood as a targeted NIH effort to push the field toward practical, evidence-based methods for identifying CTE in living individuals and quantifying how it changes, using imaging and biomarker strategies across several years. By prioritizing longitudinal measurement and consensus diagnostic development, it aims to create the scientific infrastructure needed for credible, well-designed clinical trials that can eventually test interventions to prevent CTE or slow its progression.
Frequently Asked Questions (FAQs)
What is the official title of this NIH funding opportunity?
The opportunity is titled "Detect, Define and Measure the Progression of Chronic Traumatic Encephalopathy (U01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-NS-14-012.
What type of funding mechanism is being used?
This opportunity uses a cooperative agreement mechanism (U01), which generally indicates substantial NIH program involvement in the funded project, including coordination expectations, milestones, and collaboration between awardees and NIH staff.
Is this a discretionary research program?
Yes. The announcement describes it as a discretionary research program.
What is the main goal of the project this opportunity is trying to support?
The core aim is to support a tightly coordinated, multi-year effort to identify and track signs of neurodegeneration in living people who meet criteria for a probable or possible diagnosis of chronic traumatic encephalopathy (CTE), using brain imaging and other biological markers.
Does this opportunity focus on diagnosing CTE only after death?
No. A central emphasis is studying living individuals (in vivo) rather than focusing on CTE only after death, with the goal of improving how CTE is recognized, characterized, and monitored over time.
What scientific approach is emphasized in this funding opportunity?
The opportunity emphasizes longitudinal study of participants over time and the use of brain imaging and other biological markers (biomarkers) to detect, characterize, and measure changes associated with CTE progression.
How long is the expected longitudinal follow-up window?
The announcement describes a longitudinal window of roughly three to five years.
What kinds of outcomes or evidence are applicants expected to generate?
Applicants are expected to follow participants over time and generate evidence linking changes in imaging and biomarker measures to clinical changes, with an intent to clarify underlying neurological mechanisms and enable better tracking of disease progression during life.
What problem in the field is this opportunity trying to address?
It targets a major challenge: the lack of widely accepted methods to diagnose and track CTE progression during life.
What deliverable is implied as a major outcome of the initiative?
A major implied deliverable is the development of a consensus diagnosis framework that can be used consistently across studies and can serve as a foundation for future clinical trials.
How does this opportunity relate to future clinical trials?
By developing more reliable ways to identify individuals who likely have CTE and to measure how quickly it is progressing, the project is intended to help set up the next generation of clinical trials aimed at preventing CTE or slowing its neurodegenerative course.
Why is a U01 cooperative agreement used instead of a standard research grant?
The U01 structure is typically used when the project requires standardized methods, shared protocols, or coordinated decision-making to produce results the broader research community can adopt, and when NIH intends to be actively involved programmatically.
How many awards were anticipated?
The announcement anticipated a single award.
What was the estimated total funding level?
The estimated total funding level was about $2.3 million.
Is cost sharing or matching required?
No. The announcement states there was no cost-sharing or matching requirement.
What is the CFDA number associated with this opportunity?
The CFDA listing is 93.853, titled "Extramural Research Programs in the Neurosciences and Neurological Disorders."
What general category does this funding opportunity fall under?
It falls under the health category and aligns with NIH neuroscience priorities and neurological disease research.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
When was this opportunity posted?
The posting date was July 29, 2014.
What was the application closing date?
The original and current closing date was October 31, 2014.
When was the opportunity archived?
The archive date was December 1, 2014.
Is this opportunity still open?
No. Based on the closing date (October 31, 2014) and the archive date (December 1, 2014), this specific funding opportunity is closed and archived.
What types of U.S. organizations were eligible to apply?
Eligibility was broad and included multiple U.S.-based organizational types across government, academic, nonprofit, and business sectors, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (with certain limitations noted in the announcement), small businesses, and other for-profit organizations (excluding small businesses where specified).
Which government entities were eligible to apply?
Eligible governmental entities included state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility included federally recognized tribal governments, other tribal organizations, and tribally controlled colleges and universities.
Were minority-serving institutions specifically recognized as eligible?
Yes. The opportunity explicitly recognized institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs) as eligible.
Were faith-based or community-based organizations eligible?
Yes. The announcement explicitly included faith-based or community-based organizations as eligible.
Could federal agencies apply?
Yes. The opportunity indicated eligible federal agencies were included among eligible applicants.
Are non-U.S. (foreign) organizations eligible to apply as the primary applicant?
No. Foreign institutions were not eligible to apply as the primary applicant.
Are foreign components allowed in the project?
Yes. The announcement allowed foreign components as defined in NIH policy, and it also allowed non-domestic components of U.S. organizations to participate.
Where could applicants find the full announcement?
The full announcement was available through the NIH grants guide at the link referenced in the posting.
Who was listed as the contact for access or technical issues?
The contact point listed was the NIH Office of Extramural Research webmaster, indicating support through the standard NIH electronic announcement system (no scientific program contact was included in the excerpt provided).
What makes this initiative "tightly coordinated"?
The description points to a coordinated, multi-year effort and the use of a U01 cooperative agreement, which typically involves NIH programmatic involvement, coordination expectations, milestones, and collaboration aimed at producing standardized, broadly adoptable outputs (such as shared protocols or consensus diagnostic approaches).
What is the overall intent of the funded work, in practical terms?
In practical terms, the opportunity is designed to move the field toward better tools for in vivo detection and staging of CTE by using imaging and biomarker strategies over several years to quantify changes and relate them to clinical progression.
Browse more opportunities from the same category: Health
Next opportunity: Enhance global health security and implementation of International Health Regulations.
Previous opportunity: Digital Archival Film Photograph Collections at San Francisco Maritime National Historical Park (SAFR)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA NS 14 012
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA NS 14 012) also looked into and applied for these:
| Funding Opportunity |
|---|
| Enhance global health security and implementation of International Health Regulations. Apply for EP IDS 14 014 Funding Number: EP IDS 14 014 Agency: Assistant Secretary for Preparedness and Response Category: Health Funding Amount: $350,000 |
| Office of Tribal Self Governance Program Planning Cooperative Agreement Apply for HHS 2014 IHS TSGP 0001 Funding Number: HHS 2014 IHS TSGP 0001 Agency: Indian Health Service Category: Health Funding Amount: $120,000 |
| Tuskegee University Apology Commemoration Activities Apply for CDC RFA PS15 1504 Funding Number: CDC RFA PS15 1504 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $300,000 |
| Enhancing Cross National Research within the Health and Retirement Study Family of Studies (R01) Apply for RFA AG 15 015 Funding Number: RFA AG 15 015 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NHLBI Career Transition Award for Intramural Fellows (K22) Apply for PAR 14 302 Funding Number: PAR 14 302 Agency: National Institutes of Health Category: Health Funding Amount: $249,000 |
| The NIGMS Human Genetic Cell Repository (U42) Apply for RFA GM 15 005 Funding Number: RFA GM 15 005 Agency: National Institutes of Health Category: Health Funding Amount: $2,800,000 |
| Institutional Development Award (IDeA) Program Infrastructure for Clinical and Translational Research (IDeA CTR)(U54) Apply for PAR 14 303 Funding Number: PAR 14 303 Agency: National Institutes of Health Category: Health Funding Amount: $4,000,000 |
| USAID/Uganda Karamoja Health Apply for RFA 617 14 000010 Funding Number: RFA 617 14 000010 Agency: Uganda USAID Kampala Category: Health Funding Amount: $20,000,000 |
| Immune and Inflammatory Mechanisms in Alzheimers Disease (R01) Apply for RFA AG 15 018 Funding Number: RFA AG 15 018 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| USAID/Uganda Social Marketing Activity Apply for RFA 617 14 000011 Funding Number: RFA 617 14 000011 Agency: Uganda USAID Kampala Category: Health Funding Amount: $24,000,000 |
| NIMH Mentoring Networks for Mental Health Research Education (R25) Apply for PAR 14 304 Funding Number: PAR 14 304 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| NIMH Short Courses for Mental Health Related Research Education (R25) Apply for PAR 14 305 Funding Number: PAR 14 305 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| NIMH Research Education Programs for Psychiatry Residents (R25) Apply for PAR 14 306 Funding Number: PAR 14 306 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Platform Delivery Technologies for Nucleic Acid Therapeutics (R43/R44) Apply for PA 14 307 Funding Number: PA 14 307 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Platform Delivery Technologies for Nucleic Acid Therapeutics (R41/R42) Apply for PA 14 308 Funding Number: PA 14 308 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Molecular and Cellular Substrates of Complex Brain Disorders (R01) Apply for PAR 14 309 Funding Number: PAR 14 309 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Molecular and Cellular Substrates of Complex Brain Disorders (R21) Apply for PAR 14 310 Funding Number: PAR 14 310 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| ACVVR FY 14 Apply for EP IDS 14 016 Funding Number: EP IDS 14 016 Agency: Assistant Secretary for Preparedness and Response Category: Health Funding Amount: $700,000 |
| Childrens Hospitals Graduate Medical Education (CHGME) Payment Program Apply for HRSA 15 018 Funding Number: HRSA 15 018 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Enhancing Public Health Surveillance of Autism Spectrum Disorder and Other Developmental Disabilities through the Autism and Developmental Disabilities Monitoring (ADDM) Network Apply for CDC RFA DD15 1501 Funding Number: CDC RFA DD15 1501 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $475,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA NS 14 012", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.