Opportunity Information: Apply for RFA RM 12 024
Apply for RFA RM 12 024
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Determinants and Consequences of Personalized Health Care and Prevention (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Nov 21, 2012 and posted on Nov 21, 2012.
- Applicants must submit their applications by Feb 28, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,700,000.00 to eligible and selected applicants.
- Eligible applicants include: State governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Special district governments Native American tribal governments (Federally recognized) Small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Private institutions of higher education City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity titled "Determinants and Consequences of Personalized Health Care and Prevention (U01)" (Funding Opportunity Number RFA-RM-12-024) supported economic research focused on why personalization happens in health care and prevention, how it plays out in real-world settings, and what its broader effects are. The award mechanism was a U01 cooperative agreement, meaning funded projects were expected to involve an ongoing, more collaborative relationship with NIH than a typical research grant. The central goal was to build foundational, generalizable economic knowledge and analytic frameworks about individualized interventions, rather than to run or evaluate a single named clinical program or a disease-specific personalized intervention.
At the core of the program was an interest in the economic determinants of tailoring health care and preventive services to individual characteristics or preferences, and the downstream consequences of doing so. The FOA emphasized research that can explain how personalization creates value (or fails to) for different stakeholders, including patients and families, clinicians, health systems, insurers and other payers, and society overall. It also highlighted the need to understand the incentives and constraints faced by the organizations that design, deliver, and finance personalized approaches. That includes research organizations, providers, payers, and also industry actors such as drug and device manufacturers, all of whom can influence whether personalization is adopted, how it is implemented, and whether it is used in ways that are efficient, equitable, and cost-effective.
The kinds of projects envisioned were broad economic analyses and the development of research tools that make later applied work stronger and more comparable across settings. This could include, for example, methods to measure the value of personalization under uncertainty, frameworks for modeling patient heterogeneity and preference variation, approaches to quantify tradeoffs between cost, outcomes, and patient experience, or tools that help evaluate how different payment and coverage policies affect the adoption of tailored interventions. The FOA also pointed to studies of how actual personalization differs from what might be considered "optimal" personalization from an economic perspective, and what factors explain that gap. In practical terms, it encouraged research that can clarify when personalization improves outcomes and lowers costs, when it increases spending without commensurate benefit, and what policy or market conditions tend to push systems toward one outcome versus the other.
A distinctive requirement was that the Program Director(s)/Principal Investigator(s) on funded projects had to participate in a Steering Committee. That committee was meant to coordinate thinking across projects and help identify key strategies that would accelerate progress in the field. This signals that NIH wanted the portfolio to add up to more than isolated studies, with shared direction and cross-project learning aimed at building a stronger base of economic evidence and common conceptual approaches.
In terms of eligibility, the announcement was open to a wide range of applicants, including state, county, city, township, and special district governments; public and private institutions of higher education; nonprofit organizations (including those with and without 501(c)(3) status); for-profit organizations (other than small businesses as well as small businesses); tribal governments and tribal organizations; public housing authorities; independent school districts; and a number of mission-specific institution types such as Historically Black Colleges and Universities, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and AANAPISI institutions. Importantly, non-U.S. entities were also eligible, including foreign organizations and foreign institutions, and foreign components of U.S. organizations were allowed consistent with NIH policy.
Administratively, this was a discretionary NIH opportunity in the health funding activity category (CFDA 93.310) with no cost sharing or matching requirement. The FOA was posted on November 21, 2012, with an application due date of February 28, 2013, and it was later archived on March 31, 2013. NIH listed an estimated total funding level of $2,700,000 for the program. For applicants or readers needing the official text, NIH provided the full announcement through its grants guide and offered NIH Office of Extramural Research (OER) webmaster contact points for access or linking issues.
Overall, the opportunity was essentially an effort to strengthen the economic science behind personalized health care and prevention by building general frameworks, models, and measurement approaches that can be reused across diseases, technologies, and delivery contexts. The emphasis was on understanding the broad drivers and impacts of personalization in health and prevention systems, not on testing a particular personalized treatment or running a condition-specific demonstration project.
Frequently Asked Questions (FAQs)
What is this NIH funding opportunity?
This opportunity was an NIH Funding Opportunity Announcement (FOA) titled "Determinants and Consequences of Personalized Health Care and Prevention (U01)" with Funding Opportunity Number RFA-RM-12-024. It supported economic research on why personalization occurs in health care and prevention, how it operates in real-world settings, and what its broader effects are.
What is the main purpose of the FOA?
The central goal was to build foundational, generalizable economic knowledge and analytic frameworks about individualized (personalized) interventions. The emphasis was on reusable methods, models, and measures that could strengthen future applied work across many diseases, technologies, and delivery settings, rather than running or evaluating a single named clinical program or a disease-specific personalized intervention.
What does "personalized health care and prevention" mean in this FOA?
In this FOA, personalization refers to tailoring health care and preventive services to individual characteristics or preferences. The FOA focused on the economic determinants of that tailoring and the downstream consequences of doing so.
What kind of research did NIH want to fund under this announcement?
The FOA envisioned broad economic analyses and the development of research tools that would make later applied research stronger and more comparable across settings. It encouraged research aimed at explaining how personalization creates value (or fails to) for different stakeholders and how incentives and constraints shape adoption and implementation.
Was the focus on evaluating a single clinical program or a specific disease area?
No. The FOA explicitly emphasized building general frameworks and economic evidence about individualized interventions. It was not primarily about testing one particular personalized treatment, running a condition-specific demonstration, or evaluating a single named program.
What award mechanism was used?
The FOA used the U01 cooperative agreement mechanism.
What does a U01 cooperative agreement imply for how projects are run?
A U01 cooperative agreement means funded projects were expected to involve an ongoing, more collaborative relationship with NIH than a typical research grant.
What were the key themes or questions the FOA wanted economic research to address?
Based on the FOA description, NIH was interested in research that clarifies:
- Why personalization happens in health care and prevention (its economic determinants).
- How personalization plays out in real-world settings (implementation and adoption).
- What the broader effects of personalization are (its consequences).
- When personalization improves outcomes and lowers costs versus when it increases spending without commensurate benefit.
- Which policy or market conditions tend to push systems toward more efficient, equitable, and cost-effective use of personalization.
Which stakeholders were explicitly mentioned as being affected by personalization?
The FOA highlighted value and impacts for multiple stakeholders, including patients and families, clinicians, health systems, insurers and other payers, and society overall.
Did the FOA address incentives and constraints in the health system?
Yes. A major emphasis was understanding the incentives and constraints faced by organizations that design, deliver, and finance personalized approaches. The FOA pointed to organizations such as research organizations, providers, payers, and industry actors (including drug and device manufacturers) as influencing adoption, implementation, and whether personalization is used efficiently and equitably.
What kinds of methods or tools did the FOA suggest could be developed?
Examples mentioned in the FOA included:
- Methods to measure the value of personalization under uncertainty.
- Frameworks for modeling patient heterogeneity and preference variation.
- Approaches to quantify tradeoffs among cost, outcomes, and patient experience.
- Tools to evaluate how payment and coverage policies affect adoption of tailored interventions.
Did the FOA encourage comparing "actual" personalization to "optimal" personalization?
Yes. The FOA pointed to studies examining how real-world personalization differs from what might be considered "optimal" personalization from an economic perspective, and research into what factors explain that gap.
Was participation in a Steering Committee required?
Yes. A distinctive requirement was that the Program Director(s)/Principal Investigator(s) on funded projects had to participate in a Steering Committee.
What was the purpose of the Steering Committee?
The Steering Committee was intended to coordinate thinking across projects and identify key strategies that would accelerate progress in the field. This reflected NIH's intent for cross-project learning and shared direction so that the overall portfolio would add up to more than isolated studies.
Who was eligible to apply?
The FOA was open to a wide range of applicants, including:
- State, county, city, township, and special district governments.
- Public and private institutions of higher education.
- Nonprofit organizations (with and without 501(c)(3) status).
- For-profit organizations (including small businesses and other than small businesses).
- Tribal governments and tribal organizations.
- Public housing authorities and independent school districts.
- Mission-specific institution types such as HBCUs, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and AANAPISI institutions.
Were non-U.S. organizations eligible?
Yes. Non-U.S. entities were eligible, including foreign organizations and foreign institutions. Foreign components of U.S. organizations were also allowed consistent with NIH policy.
Was cost sharing or matching required?
No. The FOA specified that there was no cost sharing or matching requirement.
What was the estimated total funding level?
NIH listed an estimated total funding level of $2,700,000 for the program.
What is the funding activity category and CFDA number?
The FOA was described as a discretionary NIH opportunity in the health funding activity category, with CFDA number 93.310.
When was the FOA posted, when were applications due, and when was it archived?
The FOA was posted on November 21, 2012. The application due date was February 28, 2013. The announcement was later archived on March 31, 2013.
Where could applicants find the official announcement text?
NIH provided the full announcement through its grants guide. NIH also offered NIH Office of Extramural Research (OER) webmaster contact points for access or linking issues.
What was NIH trying to achieve overall with this opportunity?
Overall, the opportunity aimed to strengthen the economic science behind personalized health care and prevention by developing general frameworks, models, and measurement approaches that could be reused across diseases, technologies, and delivery contexts. The focus was on understanding broad drivers and impacts of personalization in health and prevention systems.
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