Opportunity Information: Apply for RFA HL 15 003
Apply for RFA HL 15 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Developing Improved Assessments of Tissue Oxygenation (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Apr 16, 2014 and posted on Apr 15, 2014.
- Applicants must submit their applications by Jun 30, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $450,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Small businesses.
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Opportunity Summary:
Developing Improved Assessments of Tissue Oxygenation (R43/R44) is a National Institutes of Health (NIH) small business funding opportunity focused on creating or upgrading device-based tools that can measure how microvascular blood flow and tissue oxygenation change over time. The goal is to support clinical research by improving the ability to track dynamic, real-time shifts in regional perfusion (blood delivery at the tissue level) and oxygen delivery, rather than relying only on static or indirect measurements. A major emphasis is on devices that can capture temporal changes in tissue perfusion and oxygenation after red blood cell transfusion, as well as tools useful for studying or monitoring peripheral vascular disease, where impaired blood flow can lead to tissue ischemia and downstream complications.
This opportunity is offered under the SBIR/STTR-style mechanisms R43/R44, meaning it is aimed specifically at small businesses developing innovative biomedical technologies that are not yet fully mature but are ready for structured research and development. The announcement anticipates a small number of awards (about three total) with an estimated total funding amount of approximately $450,000 across all awards. The program falls under the NIH health research mission and is associated with CFDA 93.839, Blood Diseases and Resources Research. There is no cost-sharing or matching requirement, which reduces financial barriers for small companies that may not have large reserves of non-federal capital.
Key administrative details include a posting date of April 15, 2014, with the application closing date set for June 30, 2014, and an archive date of July 31, 2014. The funding opportunity number is RFA-HL-15-003. Eligible applicants are limited to small businesses, reflecting the intent to push forward translational device innovation that can move from concept and prototyping into practical clinical research tools. The full announcement and official requirements were provided through the NIH grants portal, and NIH’s Office of Extramural Research (OER) webmaster contact information was included for applicants needing help accessing or linking to the complete funding notice.
In practical terms, the FOA is trying to address a persistent clinical research gap: even when systemic measures like blood pressure, hemoglobin, or arterial oxygen saturation look acceptable, tissue-level oxygen delivery can still be inadequate due to microvascular dysfunction, regional perfusion deficits, or impaired oxygen extraction. By encouraging better devices for measuring these tissue-level dynamics, NIH is signaling interest in technologies that could produce more sensitive endpoints for clinical studies, help interpret the physiologic impact of transfusion beyond hemoglobin change alone, and improve the assessment of diseases where blood flow to extremities is compromised. Potentially relevant device concepts could include noninvasive or minimally invasive sensors, imaging or spectroscopy-based approaches, or other physiologic monitoring platforms, as long as they meaningfully improve the measurement of changing microvascular perfusion and tissue oxygenation in a clinical research setting.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Developing Improved Assessments of Tissue Oxygenation (R43/R44).
Which agency is offering this grant?
This opportunity is offered by the National Institutes of Health (NIH).
What is the funding opportunity number (FOA number)?
The FOA number is RFA-HL-15-003.
What is the main goal of this FOA?
The goal is to support the creation or improvement of device-based tools that can measure how microvascular blood flow and tissue oxygenation change over time, with an emphasis on capturing dynamic, real-time shifts in regional perfusion and oxygen delivery for clinical research.
What specific measurement problem is NIH trying to solve?
The FOA targets a clinical research gap where standard systemic measures (for example, blood pressure, hemoglobin, or arterial oxygen saturation) can look acceptable while tissue-level oxygen delivery remains inadequate due to factors such as microvascular dysfunction, regional perfusion deficits, or impaired oxygen extraction. The intent is to enable better measurement of these tissue-level dynamics.
What types of technologies or products does this FOA focus on?
The FOA focuses on device-based assessment tools for tracking microvascular perfusion and tissue oxygenation over time. Examples mentioned as potentially relevant include noninvasive or minimally invasive sensors, imaging approaches, spectroscopy-based approaches, and other physiologic monitoring platforms, as long as they meaningfully improve measurement of changing microvascular perfusion and tissue oxygenation in a clinical research setting.
Does the FOA emphasize static measurements or dynamic measurements?
The FOA emphasizes dynamic measurements, specifically the ability to track temporal changes and real-time shifts in regional perfusion and oxygen delivery, rather than relying only on static or indirect measures.
What clinical research area receives major emphasis in this FOA?
A major emphasis is on devices that can capture temporal changes in tissue perfusion and oxygenation after red blood cell transfusion.
Is peripheral vascular disease included in the intended use cases?
Yes. The FOA also highlights tools useful for studying or monitoring peripheral vascular disease, where impaired blood flow can contribute to tissue ischemia and downstream complications.
What do R43/R44 mean in this announcement?
R43/R44 are SBIR/STTR-style mechanisms used by NIH for small business research and development efforts. In this FOA, they are described as supporting small businesses developing innovative biomedical technologies that are not fully mature but are ready for structured R&D.
Who is eligible to apply?
Eligible applicants are limited to small businesses.
Is cost-sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
How many awards are expected?
The FOA anticipates a small number of awards, described as about three total.
What is the estimated total funding amount?
The estimated total funding amount is approximately $450,000 across all awards.
What NIH program classification is associated with this FOA (CFDA number)?
The FOA is associated with CFDA 93.839, titled Blood Diseases and Resources Research.
When was the opportunity posted?
The posting date is April 15, 2014.
What is the application closing date?
The application closing date is June 30, 2014.
When does the announcement archive?
The archive date is July 31, 2014.
Where can applicants find the full official requirements?
The full announcement and official requirements were provided through the NIH grants portal.
Is there a contact for help accessing or linking to the funding notice?
Yes. The information provided notes that NIH’s Office of Extramural Research (OER) webmaster contact information was included for applicants needing help accessing or linking to the complete funding notice.
What kind of outcomes does NIH hope improved devices will enable in clinical research?
NIH is signaling interest in technologies that could produce more sensitive endpoints for clinical studies, help interpret the physiologic impact of red blood cell transfusion beyond hemoglobin change alone, and improve assessment in conditions where blood flow to extremities is compromised.
Does this FOA focus on clinical care deployment or clinical research tools?
Based on the information provided, the FOA is focused on improving measurement capabilities specifically to support clinical research, particularly for tracking dynamic changes in regional perfusion and tissue oxygenation.
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