Opportunity Information: Apply for RFA HL 15 007
Apply for RFA HL 15 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Developing Improved Assessments of Tissue Oxygenation (R41)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Apr 16, 2014 and posted on Apr 15, 2014.
- Applicants must submit their applications by Jun 30, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $150,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The grant opportunity "Developing Improved Assessments of Tissue Oxygenation (R41)" (Funding Opportunity Number RFA-HL-15-007) is a National Institutes of Health (NIH) small business funding announcement focused on advancing device technologies that can measure how microvascular blood flow and tissue oxygenation change over time. The central idea is to support development and refinement of tools that can capture dynamic, real-time or near-real-time shifts in regional perfusion (blood flow through small vessels) and oxygen delivery to tissues in ways that are useful for clinical research. Rather than emphasizing static, one-time measurements, this opportunity targets technologies capable of tracking temporal patterns and physiologic responses, which is often where current clinical and research tools fall short.
A major emphasis of the announcement is on devices that can assess how tissue perfusion and oxygenation respond after red blood cell transfusion, as well as devices applicable to peripheral vascular disease. In practical terms, this means the NIH was looking for measurement approaches that can show whether transfused red blood cells actually improve oxygen delivery at the tissue level, and how quickly or effectively those changes occur. Similarly, in peripheral vascular disease, where impaired blood flow can lead to pain, poor wound healing, and tissue damage, the program highlights the need for improved monitoring of localized perfusion and oxygenation changes over time. The overall intent is to enable better clinical research endpoints and mechanistic insights by using devices that provide more sensitive, time-resolved, and region-specific data about microcirculation and oxygenation.
This is an R41 mechanism, which indicates it is part of the Small Business Innovation Research (SBIR) pathway and corresponds to a Phase I award. As a result, the eligible applicants are limited to small businesses, and the funded work is expected to be early-stage, feasibility-oriented development that demonstrates scientific and technical merit and positions the technology for further development. The opportunity is categorized as a discretionary grant in the health activity area, and it is tied to CFDA 93.839 (Blood Diseases and Resources Research), signaling alignment with heart, lung, and blood-related research priorities and the infrastructure around blood and vascular function.
In terms of funding specifics, the announcement anticipated one award, with an estimated total funding amount of $150,000 and an award ceiling of $150,000. There was no cost sharing or matching requirement, which is typical for many NIH SBIR solicitations and lowers the barrier for small businesses to propose high-risk, high-reward technical development. Key dates associated with the opportunity include a posted date of April 15, 2014, and an original and current closing date of June 30, 2014, with an archive date of July 31, 2014, indicating this specific solicitation cycle is no longer active.
The administering agency is the NIH, and the announcement provided a reference link to the full solicitation on the NIH grants site. For access or technical issues related to the electronic posting, the contact listed is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV). Overall, the opportunity was narrowly targeted: it sought small business-led device innovation that could materially improve how clinical researchers measure and interpret microvascular blood flow and tissue oxygenation dynamics, especially in settings where understanding oxygen delivery changes over time is clinically and scientifically important, such as transfusion response and peripheral vascular disease.
FAQs: Developing Improved Assessments of Tissue Oxygenation (R41) (RFA-HL-15-007)
What is the main goal of this grant opportunity?
The opportunity focuses on advancing device technologies that can measure how microvascular blood flow and tissue oxygenation change over time. The aim is to support tools that capture dynamic, real-time or near-real-time shifts in regional perfusion and oxygen delivery in ways that are useful for clinical research.
What kinds of measurements are emphasized: static or time-resolved?
This announcement emphasizes time-resolved measurements rather than one-time, static readings. It targets technologies capable of tracking temporal patterns and physiologic responses, especially where existing clinical and research tools often fall short.
What does "microvascular blood flow" mean in this context?
Here, microvascular blood flow refers to blood flow through the small vessels (microcirculation) in tissues. The program interest is in measuring regional perfusion and how that perfusion changes over time.
What does the grant mean by "tissue oxygenation"?
Tissue oxygenation refers to oxygen delivery to tissues and how well tissues are being supplied with oxygen. The opportunity is concerned with assessing how oxygenation changes dynamically over time and across specific regions.
What types of technologies are being sought?
The solicitation is aimed at device technologies that can provide more sensitive, time-resolved, and region-specific data about microcirculation and oxygenation. The intent is to improve clinical research endpoints and mechanistic understanding by capturing dynamic changes.
Why is there an emphasis on red blood cell transfusion?
A major emphasis is on devices that can assess how tissue perfusion and oxygenation respond after red blood cell transfusion. In practical terms, the NIH was looking for measurement approaches that can show whether transfused red blood cells actually improve oxygen delivery at the tissue level, and how quickly or effectively those changes occur.
How does peripheral vascular disease fit into the scope?
The opportunity also highlights devices applicable to peripheral vascular disease, where impaired blood flow can lead to pain, poor wound healing, and tissue damage. The program underscores the need for improved monitoring of localized perfusion and oxygenation changes over time in these settings.
Is this funding intended for early-stage development or later-stage commercialization?
This is intended for early-stage, feasibility-oriented development. The funded work is expected to demonstrate scientific and technical merit and position the technology for further development.
What does the R41 mechanism indicate?
R41 indicates the Small Business Innovation Research (SBIR) pathway and corresponds to a Phase I award. That generally signals a focus on feasibility and early proof-of-concept development within a small business-led project structure.
Who is eligible to apply?
Eligible applicants are limited to small businesses, consistent with the SBIR Phase I (R41) mechanism.
How many awards were anticipated under this announcement?
The announcement anticipated one award.
What was the total anticipated funding amount and the award ceiling?
The estimated total funding amount was $150,000, and the award ceiling was $150,000.
Was cost sharing or matching required?
No. The opportunity indicated there was no cost sharing or matching requirement.
What is the CFDA number associated with this opportunity, and what does it indicate?
The opportunity is tied to CFDA 93.839 (Blood Diseases and Resources Research). This signals alignment with heart, lung, and blood-related research priorities and work connected to blood and vascular function.
What agency administered this funding opportunity?
The administering agency is the National Institutes of Health (NIH).
What is the Funding Opportunity Number?
The Funding Opportunity Number is RFA-HL-15-007.
Is this opportunity still open?
No. The posted date was April 15, 2014, the original and current closing date was June 30, 2014, and the archive date was July 31, 2014. That timeline indicates the solicitation cycle described is no longer active.
What were the key dates listed in the announcement?
Key dates included: Posted date (April 15, 2014), closing date (June 30, 2014), and archive date (July 31, 2014).
What is the activity area and award type?
The opportunity was categorized as a discretionary grant in the health activity area.
What is the central research use case for the devices supported here?
The central research use case is enabling better clinical research endpoints and mechanistic insights by measuring dynamic, region-specific changes in microvascular perfusion and tissue oxygenation over time, particularly in transfusion response and peripheral vascular disease contexts.
What should applicants do if they have trouble accessing the electronic posting?
For access or technical issues related to the electronic posting, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Where could applicants find the full solicitation?
The announcement referenced a link to the full solicitation on the NIH grants site.
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