Opportunity Information: Apply for RFA HL 15 019
Apply for RFA HL 15 019
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Developing Improved Assessments of Tissue Oxygenation (R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Apr 16, 2014 and posted on Apr 15, 2014.
- Applicants must submit their applications by Nov 16, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The funding opportunity titled "Developing Improved Assessments of Tissue Oxygenation (R44)" (Funding Opportunity Number RFA-HL-15-019) is a National Institutes of Health (NIH) small business grant program focused on advancing tools that can measure how blood flow and oxygen delivery change over time in living tissue. The central goal is to support the development or meaningful improvement of devices that assess dynamic microvascular blood flow and tissue oxygenation, especially in ways that are useful for clinical research rather than purely laboratory or preclinical work. In practical terms, NIH is looking for technology that can capture the real-time or near-real-time behavior of perfusion and oxygenation in specific regions of the body, reflecting how well oxygen is being delivered at the microcirculatory level, not just what is happening in large vessels or what systemic vital signs suggest.
A particular emphasis of this opportunity is on devices that can measure temporal changes in regional perfusion and oxygen delivery in two clinically important scenarios. First, NIH highlights interest in technologies that can track how tissue perfusion and oxygenation respond after red blood cell transfusion. That focus reflects a need for better ways to understand whether transfusions are actually improving oxygen delivery to tissues in meaningful, measurable ways, and how that response evolves over time. Second, the announcement calls out peripheral vascular disease as another priority area, where compromised blood flow can lead to inadequate tissue oxygenation and where sensitive, localized, time-resolved measurements could strengthen clinical studies and potentially guide future clinical decision-making. The repeated emphasis on "dynamic changes" signals that static, single-time-point measurements are not the main target; instead, the program is oriented toward instruments that can detect trends, response curves, and physiologic fluctuations in microvascular perfusion and oxygenation.
From a funding and eligibility standpoint, this is a discretionary grant mechanism under the NIH umbrella, categorized within the health funding activity area and associated with CFDA number 93.839 (Blood Diseases and Resources Research). The eligible applicants are small businesses, consistent with the R44 mechanism, which is commonly used for Small Business Innovation Research (SBIR) projects that are moving beyond early feasibility toward further development and validation. The announcement anticipated making around two awards, with an estimated total funding amount of approximately $1,000,000 across the opportunity. The award ceiling listed is $500,000, which effectively frames the maximum budget NIH expected per award under this solicitation. There is no cost sharing or matching requirement, meaning applicants were not required to contribute non-federal funds as a condition of receiving an award.
Key administrative dates indicate the opportunity was posted in mid-April 2014 (Posted Date: April 15, 2014; Creation Date: April 16, 2014) and had a closing date of November 16, 2015, with the archive date listed as December 17, 2015. While those dates show the specific solicitation is no longer active, the summary of the FOA still provides a clear picture of NIH priorities at the time: encouraging small businesses to build or upgrade clinical research devices capable of tracking microvascular blood flow and tissue oxygenation over time, with special interest in evaluating physiologic responses after red blood cell transfusion and in the context of peripheral vascular disease. For applicants or researchers looking for the original full text, the opportunity referenced an NIH grants page for additional details, and provided NIH Office of Extramural Research (OER) webmaster contacts for access or technical linking issues.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Developing Improved Assessments of Tissue Oxygenation (R44)" and the Funding Opportunity Number (FON) is RFA-HL-15-019.
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity under the NIH small business grant program framework.
What is the main goal of the program?
The central goal is to support development or meaningful improvement of devices that can assess dynamic microvascular blood flow and tissue oxygenation over time in living tissue, especially in ways that are useful for clinical research rather than purely laboratory or preclinical work.
What kinds of measurements are being prioritized?
The program prioritizes tools that can capture real-time or near-real-time behavior of regional perfusion and oxygenation and reflect oxygen delivery at the microcirculatory level, rather than focusing only on large-vessel circulation or systemic vital signs.
Does NIH prefer dynamic (time-resolved) measurements or single time-point measurements?
Dynamic, time-resolved measurements are the clear emphasis. The repeated focus on "dynamic changes" indicates that static, single-time-point measurements are not the primary target of this solicitation.
What clinical research scenarios are specifically emphasized?
Two scenarios are explicitly highlighted: (1) tracking how tissue perfusion and oxygenation respond after red blood cell transfusion, and (2) measuring perfusion and oxygenation in the context of peripheral vascular disease.
Why is red blood cell transfusion response a priority area?
The FOA highlights a need for better ways to determine whether transfusions are improving oxygen delivery to tissues in meaningful, measurable ways, and to characterize how that response evolves over time.
Why is peripheral vascular disease a priority area?
Peripheral vascular disease can involve compromised blood flow that leads to inadequate tissue oxygenation. The announcement emphasizes that sensitive, localized, time-resolved measurements could strengthen clinical studies and potentially guide future clinical decision-making.
Is this opportunity intended for purely laboratory or preclinical tools?
The emphasis is on devices useful for clinical research rather than tools intended only for laboratory or preclinical work.
What mechanism does this funding opportunity use?
The solicitation uses the NIH R44 mechanism, commonly associated with Small Business Innovation Research (SBIR) projects that are moving beyond early feasibility toward further development and validation.
Who is eligible to apply?
Eligible applicants are small businesses, consistent with the R44 mechanism.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA 93.839, titled "Blood Diseases and Resources Research."
How much funding was expected to be available?
The opportunity anticipated a total of approximately $1,000,000 across the solicitation.
How many awards were anticipated?
The announcement anticipated making around two awards.
What was the maximum award amount (award ceiling)?
The listed award ceiling was $500,000, framing the maximum budget NIH expected per award under this solicitation.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was the opportunity posted and created?
The Posted Date was April 15, 2014, and the Creation Date was April 16, 2014.
What was the closing date for applications?
The closing date listed for the opportunity was November 16, 2015.
Is this funding opportunity still active?
No. The archive date is listed as December 17, 2015, indicating the specific solicitation is no longer active.
What is the best use of this FOA summary today if the solicitation is archived?
Even though it is no longer active, the summary still reflects NIH priorities at the time, particularly encouraging small businesses to build or upgrade clinical research devices capable of tracking microvascular blood flow and tissue oxygenation over time, with special interest in transfusion response and peripheral vascular disease.
Where could applicants look for the original full text or additional details?
The opportunity referenced an NIH grants page for additional details and provided NIH Office of Extramural Research (OER) webmaster contacts for access or technical linking issues.
What type of technology outcomes does NIH appear to be seeking?
Based on the description, NIH is seeking technology that can measure temporal changes, such as trends, response curves, and physiologic fluctuations in microvascular perfusion and tissue oxygenation, in specific regions of the body, and in a way that supports clinical research.
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