Developing Research Capacity in Africa for Studies on HIV Associated Malignancies (D43) | Apply Online

Opportunity Summary:

The grant opportunity "Developing Research Capacity in Africa for Studies on HIV Associated Malignancies (D43)" (Funding Opportunity Number RFA-CA-09-016) is a National Institutes of Health initiative, led through the National Cancer Institute, focused on building sustainable cancer research training capacity in sub-Saharan Africa. The central aim is to strengthen the ability of African institutions and investigators to conduct high-quality research on cancers linked to HIV infection, an area of major public health importance in the region. Rather than funding a single research project, the program is designed to support structured training efforts that expand local expertise, strengthen institutions, and lay the groundwork for future competitive, hypothesis-driven research studies.

A key feature of this FOA is the requirement for strategic, collaborative training programs built on partnerships between U.S. and African researchers. Applicants are expected to propose programs that do more than offer isolated workshops or short courses; the intent is to create durable, multidisciplinary research teams based in Africa. These teams should bring together the range of roles needed to carry out modern cancer and HIV-related research, including physicians and other clinical investigators, basic science researchers, epidemiologists, pathologists, data managers, and other essential personnel. The expectation is that training will be integrated and practical, helping institutions develop the full pipeline required for designing studies, collecting and managing data, handling specimens, performing analyses, and publishing results.

The long-term vision, explicitly described as extending beyond the immediate scope of this funding period, is that these African-led teams will become strong and efficient scientific partners in international collaborations focused on HIV-associated malignancies in sub-Saharan Africa. In other words, the program is meant to shift capacity toward locally anchored expertise so that African investigators and institutions can participate as equal partners in future research endeavors with investigators from the U.S. and other developed countries. To align with that goal, proposals are expected to be strongly oriented toward enabling future hypothesis-driven studies that could later compete successfully for support from other funding sources. The training plan should therefore be designed with an eye toward producing investigators and teams capable of developing fundable research questions, writing competitive grant applications, and carrying out rigorous studies.

This opportunity uses the NIH D43 mechanism, which is an international research training grant mechanism typically aimed at building research capacity through education and hands-on training. The FOA is categorized as discretionary funding and listed under education and health funding activities. The CFDA numbers associated with the announcement include 93.398 (Cancer Research Manpower) and 93.989 (International Research and Research Training), reflecting its emphasis on developing the human and institutional resources needed for cancer research in international settings.

In terms of funding, NIH anticipated a total investment of about $4,000,000 per year to support roughly 6 to 7 awards under this initiative. The award ceiling listed is $500,000. Facilities and administrative (indirect) costs are capped at 8% for all awards and subawards, which is a notable constraint for budgeting and is typical of some international training and capacity-building programs. There is no cost-sharing or matching requirement, meaning applicants are not required to provide matching funds as a condition of eligibility.

Eligible applicants include a range of U.S.-based organizations that can support international training partnerships: public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (both with and without 501(c)(3) status, as specified). While the eligible applicant types are U.S. entities, the program itself is clearly oriented toward building research capacity at African institutions through collaborative training structures, implying that strong, well-defined partnerships with African counterparts are essential for a credible application.

The announcement was posted and created on September 22, 2009, with an original and current closing date of December 17, 2009, and an archive date of January 17, 2010, indicating that this is an archived funding opportunity from that period. The full announcement was made available through the NIH grants guide, and contact support for technical access issues was provided through the NIH Office of Extramural Research (OER) webmaster.

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