Opportunity Information: Apply for PAR 09 264
Apply for PAR 09 264
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "NIH Blueprint for Neuroscience Research Competitive Revisions for Studies Focused on Neuropathic Pain or Neural Plasticity to Promote Collaborative Pain Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.361 Nursing Research 93.389 National Center for Research Resources 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Sep 22, 2009 and posted on Sep 22, 2009.
- Applicants must submit their applications by Nov 23, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $375,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $75,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public and State controlled institutions of higher education State governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH Blueprint for Neuroscience Research Competitive Revisions for Studies Focused on Neuropathic Pain or Neural Plasticity to Promote Collaborative Pain Research (R01) (Funding Opportunity Number PAR-09-264) was a National Institutes of Health grant opportunity designed to spark new, cross-disciplinary collaborations aimed at understanding how acute pain becomes chronic pain. Issued under the NIH Blueprint for Neuroscience Research, a partnership of 16 NIH Institutes, Centers, and Offices that jointly support neuroscience, the opportunity specifically tried to bring together two communities that do not always work side by side: pain researchers and non-pain neuroscientists who study neural plasticity. The central idea was that many fields of neuroscience have deep experience studying how biological systems shift from normal function to disease states, and NIH wanted to apply that expertise to the maladaptive neuroplastic changes believed to drive the transition from acute to chronic pain, including neuropathic pain.
Rather than funding entirely new, standalone R01 projects, this announcement focused on competitive revisions to active NIH R01 grants. Applicants were expected to propose either a collaborative, one-year pilot study or a new specific aim that would be added onto an already funded parent grant. Importantly, the parent award could be rooted in pain research or could come from neural plasticity research outside of pain; the key requirement was that the revision would create a genuine partnership bridging these areas. NIH framed these revisions as a way to generate early data, build working relationships, and lay the groundwork for later, more ambitious and innovative applications that more fully tackle mechanisms of the acute-to-chronic pain transition.
The funding mechanism was the NIH Competitive Revision (often called a revision or supplement to an existing award, but competed and peer reviewed) using the R01 activity code. NIH anticipated supporting roughly five to six competitive revisions under this FOA, with participating Blueprint Institutes committing at least $375,000 in total funding for fiscal year 2010, and signaling an intent to provide at least an additional $375,000 per year for two more years after a reissue of the announcement. Individual awards were capped with an award ceiling of $75,000. As with most federal opportunities, awards depended on the availability of funds and on receiving enough high-quality, meritorious applications.
The opportunity was broadly open in terms of institutional eligibility. Eligible applicants included a wide range of organizations such as public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), small businesses and other for-profit organizations (with limitations noted in NIH policies), local and state governments, tribal governments and tribal organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities and regional organizations. The listing also explicitly mentioned eligibility for institutions serving specific populations, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian-serving institutions, as well as faith-based and community-based organizations and eligible federal agencies. There was no cost sharing or matching requirement.
Key administrative details reflect that this was a time-limited announcement. It was posted on September 22, 2009, with an application due date (closing date) of November 23, 2009, and an archive date of December 24, 2009. The program sat within NIH’s broader neuroscience and health research portfolio and was associated with multiple CFDA program numbers spanning neuroscience, mental health, aging, child health, vision, drug and alcohol research, nursing research, and related biomedical areas, reflecting the cross-cutting Blueprint structure.
Overall, the FOA’s core message was collaborative and translational in a mechanistic sense: use short, targeted revision funding to quickly connect investigators across pain and neural plasticity research, generate pilot data, and accelerate insights into the neuroplastic mechanisms that shift pain from an acute protective signal into a persistent, maladaptive chronic condition. For full program requirements and instructions, NIH directed applicants to the detailed announcement at http://grants.nih.gov/grants/guide/pa-files/PAR-09-264.html.
Frequently Asked Questions (FAQs)
What is PAR-09-264?
PAR-09-264 is an NIH Blueprint for Neuroscience Research funding opportunity titled "Competitive Revisions for Studies Focused on Neuropathic Pain or Neural Plasticity to Promote Collaborative Pain Research (R01)." It was designed to encourage new, cross-disciplinary collaborations to better understand how acute pain transitions into chronic pain.
What was the main goal of this funding opportunity?
The main goal was to spark genuine collaborations between two groups that do not always work closely together: (1) pain researchers and (2) non-pain neuroscientists who study neural plasticity. NIH wanted to apply the broader neuroscience community's expertise in how normal biological function shifts into disease states to the maladaptive neuroplastic changes believed to drive chronic pain, including neuropathic pain.
What scientific areas did the FOA emphasize?
The FOA emphasized studies focused on neuropathic pain and neural plasticity, specifically in the context of mechanisms involved in the transition from acute pain to chronic pain. The opportunity aimed to promote mechanistic, neuroscience-driven insights into how pain becomes persistent and maladaptive.
Was this opportunity intended to fund brand-new R01 projects?
No. This announcement did not focus on entirely new, standalone R01 projects. Instead, it focused on competitive revisions to active NIH R01 grants.
What type of application was NIH seeking under this FOA?
Applicants were expected to propose either (1) a collaborative, one-year pilot study or (2) a new specific aim that would be added onto an already funded parent R01 grant. The revision needed to create a real partnership bridging pain research and neural plasticity research.
What is a "competitive revision" in this context?
This FOA used the NIH Competitive Revision mechanism (often referred to as a revision or supplement to an existing award, but competed and peer reviewed) under the R01 activity code. In other words, the request was to add new work onto an existing funded R01, and that additional work would be reviewed competitively.
Did the parent R01 have to be a pain research grant?
No. The parent award could be rooted in pain research or could come from neural plasticity research outside of pain. The key requirement was that the competitive revision would create a genuine partnership bridging pain research and neural plasticity expertise.
How long were the proposed revision projects expected to last?
The FOA described revisions as either a collaborative, one-year pilot study or a new specific aim added to the active parent R01. The emphasis was on short, targeted work that could quickly generate data and strengthen cross-disciplinary collaborations.
Why did NIH emphasize short, targeted revision funding?
NIH framed these revisions as a way to generate early data, build working relationships between investigators, and lay the groundwork for later, more ambitious and innovative applications that more fully address mechanisms of the acute-to-chronic pain transition.
How many awards did NIH expect to make?
NIH anticipated supporting roughly five to six competitive revisions under this funding opportunity.
What was the total funding NIH expected to commit?
Participating Blueprint Institutes committed at least $375,000 in total funding for fiscal year 2010. The FOA also signaled an intent to provide at least an additional $375,000 per year for two more years after a reissue of the announcement.
What was the maximum award amount per revision?
Individual awards were capped with an award ceiling of $75,000.
Were awards guaranteed?
No. As with most federal opportunities, awards depended on the availability of funds and on receiving enough high-quality, meritorious applications.
Who was eligible to apply?
The opportunity was broadly open in terms of institutional eligibility. Eligible applicants included public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), small businesses and other for-profit organizations (with limitations noted in NIH policies), local and state governments, tribal governments and tribal organizations, U.S. territories or possessions, and non-U.S. (foreign) entities and regional organizations.
Were institutions serving specific populations explicitly included?
Yes. The listing explicitly mentioned eligibility for institutions serving specific populations, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian-serving institutions. It also noted faith-based and community-based organizations, and eligible federal agencies.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement.
When was the FOA posted and when were applications due?
The FOA was posted on September 22, 2009. The application due date (closing date) was November 23, 2009.
When was the FOA archived?
The archive date was December 24, 2009, reflecting that it was a time-limited announcement.
What NIH program or initiative issued this opportunity?
This opportunity was issued under the NIH Blueprint for Neuroscience Research, a partnership of 16 NIH Institutes, Centers, and Offices that jointly support neuroscience.
Why did the NIH Blueprint structure matter for this FOA?
The Blueprint structure reflected the cross-cutting nature of the science and the participating NIH components. It aligned with the FOA's purpose of bridging research communities and leveraging broad neuroscience expertise to address chronic pain mechanisms.
What broader research areas did the FOA connect to?
The FOA was associated with multiple CFDA program numbers spanning areas such as neuroscience, mental health, aging, child health, vision, drug and alcohol research, nursing research, and related biomedical domains. This reflected the cross-disciplinary nature of the NIH Blueprint approach.
Where could applicants find the full official announcement and instructions?
NIH directed applicants to the detailed announcement at http://grants.nih.gov/grants/guide/pa-files/PAR-09-264.html.
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