Development of Animal Models and Related Biological Materials For Research (R21) | Apply Online

Opportunity Summary:

The Development of Animal Models and Related Biological Materials For Research (R21) funding opportunity (PA 07-336) is a discretionary National Institutes of Health (NIH) grant program that supports early-stage, exploratory, or developmental projects focused on animal models and key related resources that enable biomedical research. The central goal is to fund work that creates new animal models, substantially improves existing models, or rigorously characterizes models so they become more useful for studying human diseases. A second major focus is improving the diagnosis, prevention, and control of diseases in laboratory animals when those conditions could compromise experiments or distort research findings. In practice, the FOA is aimed at strengthening the foundational tools that many different biomedical research areas rely on, rather than funding a narrow, single-disease research project.

A key requirement is that the proposed model(s) or resources must be relevant to the scientific missions of at least two categorical NIH Institutes or Centers. This emphasizes broad utility and cross-cutting impact, meaning the model should be able to serve multiple research communities or disease areas rather than only one specialized niche. The mechanism is the NIH Exploratory/Developmental grant (R21), which is generally used for projects that are innovative or high-impact but still at a stage where extensive preliminary data may be limited, and where the work is designed to establish feasibility, generate foundational data, or develop enabling resources.

The opportunity is associated with CFDA number 93.389 and was listed under the National Center for Research Resources (as reflected in the source record). Like most NIH opportunities, awards are not guaranteed; funding decisions depend on congressional appropriations, NIH priorities, and the number and quality of applications received. The announcement notes that awards are contingent on the availability of funds and the submission of a sufficient number of meritorious applications, which signals a standard peer-review and competitive funding process.

Eligibility is broad and includes many types of domestic applicants: public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (including small businesses), and multiple levels of government entities (state, county, city/township, special districts), as well as independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. Importantly, foreign institutions are eligible to apply, and faith-based or community-based organizations may also apply, expanding the pool of potential applicants beyond the typical university-centered applicant base. There is no cost sharing or matching requirement stated for this FOA, which means applicants are not required to contribute non-federal funds as a condition of receiving an award.

From a timeline standpoint, the opportunity was posted on March 23, 2007, with an original closing date of May 8, 2010 and a current closing date also listed as May 8, 2010, after which it was archived on June 7, 2010. The record indicates a creation date of December 5, 2008, which reflects how the listing was entered or updated in the source system rather than changing the original posting date. In other words, this is a historical opportunity rather than an open solicitation today, but the summary still reflects the intent and structure of the program while it was active.

For applicants seeking the full text and detailed NIH-specific instructions, the announcement provided an official link to the NIH Grants Guide (http://grants.nih.gov/grants/guide/pa-files/PA-07-336.html). The contact information in the listing points to the NIH Office of Extramural Research (OER) Webmaster for technical issues accessing or linking to the announcement, rather than a scientific/program contact, indicating the listing was primarily meant to route applicants to the full FOA where scientific scope, application requirements, and review considerations would be spelled out in detail.

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