HIV Treatment Adherence Research (R01) | Apply Online

FAQs: HIV Treatment Adherence Research (R01) - PA-07-338

What is the HIV Treatment Adherence Research (R01) opportunity (PA-07-338)?

PA-07-338 is a National Institutes of Health (NIH) discretionary grant announcement that supports scientific research and intervention development focused on improving adherence to HIV treatment. The emphasis is on understanding why adherence succeeds or fails and testing strategies that help people living with HIV take and sustain prescribed treatment as intended.

Which NIH organizations sponsor this funding opportunity?

This opportunity is sponsored jointly by three NIH institutes: the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), and the National Institute of Nursing Research (NINR).

What is the main goal of this funding opportunity?

The central goal is to support research that advances understanding of the factors that drive HIV treatment adherence and to test interventions or strategies that improve adherence over time. The announcement recognizes that adherence can be influenced by behavioral factors, mental health, substance use, social influences, and health-system factors.

What grant mechanism does PA-07-338 use?

PA-07-338 uses the NIH Research Project Grant (R01) mechanism. This mechanism is typically intended for well-developed, hypothesis-driven projects with a strong scientific premise and a defined research plan.

How should applicants decide whether to apply under this R01 FOA versus related announcements?

The announcement notes that PA-07-338 runs in parallel with related NIH funding announcements in the same topic area that use different mechanisms designed for smaller, earlier-stage, or exploratory work. The practical takeaway is to choose the mechanism that matches the maturity and scope of the proposed project; PA-07-338 is specifically for full R01-scale projects.

What related NIH funding announcements are mentioned as running in parallel?

The announcement references three related opportunities that cover the same general topic area but use different mechanisms: an R03 small grant (PA-07-339), an R21 exploratory/developmental grant (PA-07-340), and an R34 mechanism aimed at exploratory grants for mental health interventions and services (PAR-07-341).

Does this opportunity guarantee a certain number of awards?

No. The announcement does not promise a fixed number of awards. It indicates that awards depend on the availability of NIH funds and the quality and competitiveness of the applications received.

Is funding under PA-07-338 contingent on anything?

Yes. Funding decisions depend on both the availability of NIH funds and whether enough meritorious, competitive proposals are submitted.

What CFDA program numbers are associated with this opportunity?

This opportunity is tied to multiple CFDA numbers reflecting the participating institutes and their missions: 93.242 (Mental Health Research Grants), 93.279 (Drug Abuse and Addiction Research Programs), and 93.361 (Nursing Research).

Is there a cost sharing or matching requirement?

No. The announcement states there is no cost sharing or matching requirement, meaning applicants generally are not required to contribute non-federal funds as a condition of receiving the award.

Who is eligible to apply?

Eligibility is broad and includes many organization types. Examples listed include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations, small businesses, independent school districts, special district governments, city/county/state governments, public housing authorities and Indian housing authorities, and Native American tribal governments and tribal organizations.

Are for-profit organizations eligible?

Yes. The eligibility examples explicitly include for-profit organizations (other than small businesses, though small businesses are also listed as eligible).

Are small businesses eligible?

Yes. Small businesses are listed among the eligible applicant types.

Are state, local, or tribal government entities eligible?

Yes. The examples of eligible applicants include city/county/state governments, as well as Native American tribal governments and tribal organizations. Independent school districts and special district governments are also listed.

Are foreign (non-U.S.) institutions eligible to apply?

Yes. A notable feature of this opportunity is that foreign institutions are explicitly eligible to apply, opening the competition to non-U.S. organizations that can meet NIH application and compliance requirements.

When was this funding opportunity originally posted?

The announcement was originally posted on March 27, 2007.

Did this opportunity have a single deadline?

No. The announcement used multiple receipt dates rather than a single deadline.

What was the closing date and current status of this opportunity?

The opportunity carried a closing date of January 7, 2010, and an archive date of February 7, 2010. This means it was active during that period and is now archived, though it can still serve as a reference for NIH priorities and approaches during that cycle.

Where was the full announcement hosted?

The full announcement was hosted on the NIH grants website.

Who should be contacted for access or linking issues related to the announcement?

The provided contact for access or linking issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

What kinds of adherence factors does the announcement highlight as relevant to research?

The announcement highlights that adherence is influenced by multiple dimensions, including behavioral factors, mental health, substance use, social factors, and health-system factors. The opportunity is designed to support research and interventions that account for these influences.

Is PA-07-338 primarily for early-stage, exploratory projects?

No. This particular announcement uses the R01 mechanism, which is typically intended for well-developed projects with a strong scientific premise and a defined research plan. The announcement points to other mechanisms (R03, R21, R34) for smaller or earlier-stage work in the same topic area.