Opportunity Information: Apply for PA 15 087
Apply for PA 15 087
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351 Research Infrastructure Programs.
- This funding opportunity was created on Mar 4, 2015 and posted on Jan 12, 2015.
- Applicants must submit their applications by Jan 5, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the followingNon domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
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Opportunity Summary:
The grant opportunity "Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R41/R42)" (Funding Opportunity Number PA 15 087) is a National Institutes of Health (NIH) Small Business Technology Transfer (STTR) program solicitation aimed at strengthening the technology base that makes zebrafish a powerful and practical model for biomedical research. It is listed as a discretionary grant in the health area under CFDA 93.351 (Research Infrastructure Programs) and does not require cost sharing or matching funds. In plain terms, NIH is looking for small businesses to build and validate new tools that make it easier, faster, or more reliable to develop, detect, identify, and characterize zebrafish models that mirror human diseases, and to improve how valuable zebrafish genetic lines are preserved and maintained.
The scientific motivation behind the announcement is the growing role of zebrafish as a high-value research organism. Zebrafish are widely used because they are small, reproduce quickly, and have embryos that are easy to manipulate. Their optical transparency, especially at early stages, enables direct observation of development and disease processes in living animals. These traits make zebrafish particularly useful for studying gene structure and gene function in ways that can translate to human genetics and human disease biology. NIH also highlights the model's broad relevance across disciplines such as pharmacology and toxicology (including screening and safety evaluation), neurobiology and behavior (including neural development and function), and developmental biology more generally.
What NIH is encouraging through this FOA is research and development of innovative technologies, including both tangible reagents and scalable equipment, that support zebrafish research workflows. That can include tools that improve the creation of disease models (for example, methods that make genetic modification more efficient, accurate, or standardized), tools that improve detection and identification (for example, technologies that enable faster genotyping or phenotyping), and tools that improve characterization (for example, imaging, analysis, or functional assay platforms that produce higher-quality data or enable new kinds of measurements). Another major emphasis is preserving genetic stocks, which is a practical but critical need for zebrafish research communities because laboratories and repositories must maintain and safeguard large numbers of lines over time. Technologies that improve cryopreservation, stock management, quality control, or recovery of lines would fit the stated goals, as long as the approach is truly enabling and supports biomedical model development and use.
The mechanism is STTR, which is designed for small business concerns (SBCs) working in partnership with a research institution, with projects typically structured in phases (R41 and R42 align with Phase I and Phase II concepts). The overall intent is not just basic discovery, but development-oriented work that can realistically produce usable technology. High-throughput capability is specifically mentioned, signaling interest in platforms that can scale to large numbers of animals, lines, or assays, which is often essential for genetics-driven disease modeling and screening applications.
Eligibility is limited to small businesses; non-U.S. (foreign) institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible either. However, foreign components may be allowed under NIH policy as defined in the NIH Grants Policy Statement, meaning some discrete foreign collaboration could potentially be permissible if it meets NIH rules and is well-justified. The FOA was posted on January 12, 2015, created March 4, 2015, with an original closing date of January 7, 2018 and a current closing date listed as January 5, 2018. It was archived on February 5, 2018, indicating the announcement is no longer open for new applications under that specific listing, though similar or successor FOAs may exist.
For full details, NIH provided an official link to the archived program announcement (http://grants.nih.gov/grants/guide/pa-files/PA-15-087.html). Administrative help is routed through the NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues, which is typical for NIH grant postings.
FAQs: Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R41/R42) - PA-15-087
What is the title and funding opportunity number for this grant?
The opportunity is titled "Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R41/R42)" and the Funding Opportunity Number is PA-15-087.
Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What type of program is this?
It is an NIH Small Business Technology Transfer (STTR) program solicitation, using the R41/R42 mechanisms (which align with Phase I and Phase II concepts).
What is the main goal of this FOA?
The goal is to strengthen the technology base that makes zebrafish a powerful and practical model for biomedical research by supporting development and validation of new tools and technologies that improve zebrafish disease-model workflows and genetic stock preservation/maintenance.
What kinds of projects is NIH looking to fund under this announcement?
NIH is encouraging research and development of innovative technologies, including tangible reagents and scalable equipment, that support zebrafish research workflows. This includes technologies that make it easier, faster, or more reliable to develop, detect, identify, and characterize zebrafish models relevant to human disease, as well as technologies that improve preservation and maintenance of zebrafish genetic lines.
What does NIH mean by "novel and emerging technologies" in this context?
Based on the description provided, "novel and emerging" refers to enabling, development-focused technologies (tools, reagents, platforms, or equipment) that can be built and validated for practical use in zebrafish biomedical research, rather than basic discovery alone.
Why does NIH emphasize zebrafish as a biomedical research model?
NIH highlights zebrafish as high-value because they are small, reproduce quickly, have embryos that are easy to manipulate, and are optically transparent at early stages, which enables direct observation of development and disease processes in living animals. These traits support studies of gene structure and function with relevance to human genetics and disease biology.
Which research areas does NIH associate with zebrafish relevance in this announcement?
The announcement notes broad relevance across disciplines including pharmacology and toxicology (screening and safety evaluation), neurobiology and behavior (neural development and function), and developmental biology.
What stages of zebrafish model work are specifically targeted?
The FOA emphasizes technologies that support (1) development/creation of disease models, (2) detection and identification (such as faster genotyping or phenotyping), and (3) characterization (such as imaging, analysis, or functional assay platforms).
Does the FOA mention genetic modification technologies?
Yes. It gives examples such as methods that make genetic modification more efficient, accurate, or standardized as fitting the goal of improving creation of disease models.
Does the FOA encourage tools for genotyping and phenotyping?
Yes. The description specifically points to technologies that enable faster genotyping or phenotyping as examples of tools that improve detection and identification.
Does the FOA include imaging and analysis platforms?
Yes. Imaging, analysis, and functional assay platforms that produce higher-quality data or enable new kinds of measurements are described as fitting the characterization emphasis.
Why is preservation of zebrafish genetic lines a major emphasis?
Because laboratories and repositories must maintain and safeguard large numbers of zebrafish lines over time, and preserving genetic stocks is described as a practical but critical need for the zebrafish research community.
What kinds of genetic stock preservation technologies are relevant?
The FOA identifies areas such as cryopreservation, stock management, quality control, and recovery of lines, as long as the approach is enabling and supports biomedical model development and use.
Is high-throughput capability important for this FOA?
Yes. High-throughput capability is specifically mentioned, signaling interest in platforms that can scale to large numbers of animals, genetic lines, or assays, which can be important for disease modeling and screening applications.
What is the grant mechanism used in this opportunity?
The mechanism is STTR, using R41/R42, typically structured in phases that correspond to Phase I (R41) and Phase II (R42) concepts.
Who is eligible to apply?
Eligibility is limited to small businesses (small business concerns, SBCs) that participate in the STTR partnership model with a research institution.
Are non-U.S. (foreign) institutions eligible to apply?
No. Non-U.S. (foreign) institutions are not eligible to apply under this opportunity.
Are non-U.S. components of U.S. organizations allowed?
No. Non-U.S. components of U.S. organizations are stated as not eligible.
Can a project include any foreign collaboration at all?
Potentially yes. The description notes that foreign components may be allowed under NIH policy as defined in the NIH Grants Policy Statement, meaning discrete foreign collaboration could be permissible if it complies with NIH rules and is well-justified.
Is this considered a discretionary grant, and what is the program area?
Yes. It is listed as a discretionary grant in the health area.
What is the CFDA number associated with this opportunity?
The CFDA number provided is 93.351 (Research Infrastructure Programs).
Does this FOA require cost sharing or matching funds?
No. The information provided states that it does not require cost sharing or matching funds.
When was this FOA posted and when was it created?
It was posted on January 12, 2015, and created on March 4, 2015.
What were the closing dates listed for this opportunity?
The original closing date is listed as January 7, 2018, and the current closing date is listed as January 5, 2018.
Is this funding opportunity still open?
No. It was archived on February 5, 2018, which indicates the announcement is no longer open for new applications under that specific listing.
Where can applicants find the official archived announcement?
NIH provided the official link to the archived program announcement at http://grants.nih.gov/grants/guide/pa-files/PA-15-087.html.
Who should be contacted for technical issues accessing the NIH posting?
Administrative help for access or linking issues is routed through the NIH Office of Extramural Research (OER) webmaster contacts, as noted in the posting description.
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