Opportunity Information: Apply for PA 15 086
Apply for PA 15 086
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351 Research Infrastructure Programs.
- This funding opportunity was created on Mar 4, 2015 and posted on Jan 12, 2015.
- Applicants must submit their applications by Jan 5, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the followingNon domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
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Opportunity Summary:
The NIH funding opportunity titled "Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R43/R44)" (Funding Opportunity Number PA 15-086) is an SBIR grant program aimed at helping small businesses develop new tools and technology that make zebrafish-based biomedical research faster, more reliable, and more scalable. It sits in the health research infrastructure space (CFDA 93.351) and is structured as an R43/R44 mechanism, meaning it supports the typical SBIR pathway where early feasibility and proof-of-concept work (Phase I, R43) can progress into more advanced research, development, and commercialization-focused activities (Phase II, R44). The program does not require cost sharing or matching funds, which is important for small companies trying to move enabling technologies from concept to practical use.
The scientific motivation behind the opportunity is that zebrafish have become a high-value model organism across many areas of biomedical research because they are small, have a short generation time, produce large numbers of offspring, and have embryos that are relatively easy to manipulate and observe due to their optical transparency. These traits make zebrafish especially useful for studying gene function, developmental processes, and disease mechanisms in ways that can be meaningfully connected to human genetics and human disease. The FOA also recognizes that zebrafish are not just a niche genetics tool; they are widely used in pharmacology, toxicology, neurobiology, behavioral research, and developmental biology, including applications where researchers need to observe biology in real time or run many experiments in parallel.
The funding is specifically intended to stimulate innovative research and development of technologies that support the full pipeline of zebrafish model generation and use. That includes tools, reagents, and high-throughput equipment that improve the creation of zebrafish models of human disease, as well as technologies that enhance detection, identification, and characterization of those models once they exist. In practical terms, the scope is broad and enabling: it is focused on the kinds of platforms and products that make it easier to build disease models, confirm that the intended genetic or phenotypic changes are present, and measure relevant outcomes efficiently and reproducibly. Another emphasized area is the preservation of genetic stocks, which reflects a real operational need in zebrafish research to reliably maintain and archive valuable lines so that genetic resources are not lost and can be shared or rederived when needed.
Eligibility is limited to small business concerns, consistent with SBIR rules, and the announcement explicitly notes that non-U.S. (foreign) institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible. However, foreign components, as NIH defines them in its Grants Policy Statement, may be allowable in some cases. Administratively, the opportunity was posted on January 12, 2015, and the final closing date listed is January 5, 2018, with an archive date of February 5, 2018, meaning it is no longer open but remains available as a reference for the kind of projects NIH sought to fund under that initiative.
Overall, the FOA is best understood as NIH encouraging commercialization-minded R&D by small companies to remove technical bottlenecks in zebrafish research. The emphasis is on practical, innovative technologies that can be adopted by the research community, particularly those that increase throughput, improve measurement and characterization, and strengthen the infrastructure for maintaining and preserving zebrafish disease models and genetic resources.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R43/R44)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA 15-086.
What type of grant mechanism is this?
This is an NIH SBIR funding opportunity using the R43/R44 mechanism. R43 generally corresponds to SBIR Phase I (feasibility/proof-of-concept) and R44 generally corresponds to SBIR Phase II (more advanced R&D with a commercialization-oriented trajectory).
What is the overall purpose of this SBIR program?
The purpose is to help small businesses develop novel and emerging tools and technologies that make zebrafish-based biomedical research faster, more reliable, and more scalable, with an emphasis on enabling technologies that can be broadly adopted by the research community.
What scientific area does this opportunity fall under (CFDA)?
It sits in the health research infrastructure space under CFDA 93.351.
Why is NIH emphasizing zebrafish as a model organism in this program?
The FOA highlights zebrafish as a high-value biomedical model because they are small, have short generation times, produce many offspring, and have embryos that are relatively easy to manipulate and observe due to optical transparency. These features support studies of gene function, development, and disease mechanisms that can connect to human genetics and human disease.
What kinds of research areas use zebrafish, according to the FOA?
The FOA notes zebrafish are used broadly, including in genetics, pharmacology, toxicology, neurobiology, behavioral research, and developmental biology, especially where real-time observation or many parallel experiments are important.
What kinds of projects are in scope for funding?
The scope is enabling and technology-focused. It includes innovative R&D on tools, reagents, high-throughput equipment, and platforms that support the full pipeline of zebrafish model generation and use, including improved creation of zebrafish models of human disease and improved detection, identification, and characterization of those models.
Does the program support technologies for both making and analyzing zebrafish disease models?
Yes. The description emphasizes technologies that improve generating disease models (upstream) as well as technologies that help confirm and characterize genetic/phenotypic changes and measure outcomes efficiently and reproducibly (downstream).
Is high-throughput capability specifically encouraged?
Yes. The FOA explicitly mentions high-throughput equipment and also emphasizes scalability, parallel experimentation, throughput, and reproducibility as program motivations.
Does the FOA include preservation of zebrafish genetic stocks as an area of interest?
Yes. Preservation of genetic stocks is specifically emphasized as an operational need so valuable zebrafish lines can be reliably maintained, archived, shared, and rederived when needed.
Who is eligible to apply?
Eligibility is limited to small business concerns, consistent with SBIR rules.
Are non-U.S. (foreign) institutions eligible to apply?
No. The announcement explicitly states that non-U.S. (foreign) institutions are not eligible to apply.
Can a U.S. organization include non-U.S. components on the application?
No. The FOA states that non-U.S. components of U.S. organizations are not eligible.
Are any foreign components allowed at all?
The FOA notes that foreign components, as NIH defines them in its Grants Policy Statement, may be allowable in some cases.
Is cost sharing or matching required?
No. The program does not require cost sharing or matching funds.
What is the intended development pathway supported by R43/R44?
The opportunity aligns with the typical SBIR pathway: Phase I (R43) supports early feasibility and proof-of-concept work, and Phase II (R44) supports more advanced research, development, and commercialization-focused activities.
When was this opportunity posted?
It was posted on January 12, 2015.
Is this FOA still open for applications?
No. The final closing date listed is January 5, 2018, and the archive date is February 5, 2018, so it is no longer open and remains available as a reference.
What is the NIH trying to achieve with this funding opportunity?
NIH is encouraging commercialization-minded R&D by small businesses to remove technical bottlenecks in zebrafish research by building practical, innovative technologies that improve throughput, measurement, characterization, and infrastructure for maintaining and preserving zebrafish disease models and genetic resources.
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Previous opportunity: Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R41/R42)
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