Opportunity Information: Apply for PA 07 026
Apply for PA 07 026
- The National Institutes of Health in the education food and nutrition health income security and social services sector is offering a public funding opportunity titled "Developmental Biology and Regeneration of the Liver (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Nov 20, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments County governments State governments Private institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Small businesses For profit organizations other than small businesses Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Developmental Biology and Regeneration of the Liver (R01) opportunity (Funding Opportunity Number PA 07 026) is a National Institutes of Health (NIH) discretionary grant program designed to support in-depth, hypothesis-driven research on how the liver forms, grows, and repairs itself. It was built directly from scientific priorities identified by the working group on liver developmental biology and regeneration within the trans-NIH Action Plan for Liver Disease Research (referenced at liverplan.niddk.nih.gov). The central aim is to encourage strong, mechanistic studies that can clearly define the molecular and cellular processes that drive liver development and regeneration in both normal physiology and disease settings, and then leverage that knowledge toward improved therapeutic strategies for liver disease.
This announcement uses the NIH Research Project Grant (R01) mechanism, which typically supports mature research projects with substantial scope, clear experimental plans, and meaningful deliverables. It also runs alongside a separate but scientifically identical announcement that uses the R21 Exploratory/Developmental mechanism (PA 06 232). In practice, that pairing signals that NIH is interested in both early-stage, high-risk concept testing (R21) and larger, more comprehensive research programs that can pursue validated ideas in depth (R01), giving applicants a pathway depending on the maturity of their preliminary data and project readiness.
The scientific focus is explicitly on liver development and regenerative biology, with emphasis on fully characterizing underlying mechanisms. That includes clarifying how liver cell types arise and differentiate, how tissue architecture and functional units are established, how signaling networks coordinate growth and repair, and how these processes change under injury, chronic disease, or other pathological conditions. The FOA also highlights translation in the broad sense: not necessarily immediate clinical trials, but using mechanistic insight to point toward better therapies, targets, or regenerative approaches for liver disease. Overall, the opportunity is meant to strengthen the foundational science that enables improved interventions, whether those interventions eventually take the form of drugs, biologics, cell-based therapies, or strategies that enhance endogenous repair.
Funding levels and the number of awards are not fixed. NIH notes that award size and project duration will vary depending on what applicants propose, and that the total amount funded and the number of grants made will ultimately depend on the quantity, quality, costs, and durations of applications received. Rather than setting a single budget cap in the summary provided, the FOA frames funding as flexible and tied to scientific merit and program priorities, which is typical for many NIH program announcements using the R01 mechanism.
Eligibility is broad and includes many categories of domestic organizations, such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses and other for-profit organizations, state and local governments (including counties, cities or townships, special district governments, and independent school districts), public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations. The announcement also states that foreign institutions are eligible to apply, that eligible federal agencies may apply, and that faith-based or community-based organizations are permitted. No cost sharing or matching is required, removing a common barrier that can complicate budgeting for academic and nonprofit applicants.
Administratively, the FOA was posted on November 20, 2006, with multiple receipt dates rather than a single deadline, meaning applications were accepted on recurring NIH submission cycles during the active period. The archived date is June 1, 2009, indicating the specific announcement is no longer active, though similar initiatives may reappear under newer NIH funding announcements. The program spans several CFDA numbers associated with NIH research areas (including biomedical research and training and several cancer and alcohol research program listings), reflecting the cross-cutting relevance of liver development and regeneration to many NIH missions and disease areas.
For full details, NIH directs applicants to the complete announcement at http://grants.nih.gov/grants/guide/pa-files/PA-07-026.html. For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: Developmental Biology and Regeneration of the Liver (R01) - NIH (PA-07-026)
What is the purpose of this grant opportunity?
This NIH discretionary grant opportunity supports in-depth, hypothesis-driven research focused on how the liver forms, grows, and repairs itself. The emphasis is on mechanistic studies that define molecular and cellular processes underlying liver development and regeneration in both normal physiology and disease settings, with the longer-term goal of informing improved therapeutic strategies for liver disease.
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is PA-07-026.
What NIH grant mechanism does this opportunity use?
This announcement uses the NIH Research Project Grant (R01) mechanism, which is generally intended for mature research projects with substantial scope, clear experimental plans, and meaningful deliverables.
Is there a related opportunity for earlier-stage or higher-risk projects?
Yes. NIH notes a separate, scientifically identical announcement using the R21 Exploratory/Developmental mechanism (PA-06-232). The pairing reflects interest in both early-stage concept testing (R21) and more comprehensive programs that can pursue validated ideas in depth (R01).
What scientific areas does the FOA prioritize?
The scientific focus is liver development and regenerative biology, with an explicit emphasis on fully characterizing underlying mechanisms. Examples of focus areas described include how liver cell types arise and differentiate, how tissue architecture and functional units are established, how signaling networks coordinate growth and repair, and how these processes change under injury, chronic disease, or other pathological conditions.
Does the FOA require clinical trials or immediate clinical translation?
The FOA highlights translation in a broad sense, not necessarily immediate clinical trials. It encourages using mechanistic insight to point toward better therapies, targets, or regenerative approaches for liver disease, strengthening foundational science that may eventually support interventions such as drugs, biologics, cell-based therapies, or strategies that enhance endogenous repair.
Where did the scientific priorities for this program come from?
The program was built directly from scientific priorities identified by the working group on liver developmental biology and regeneration within the trans-NIH Action Plan for Liver Disease Research (referenced at liverplan.niddk.nih.gov).
How are award size and project duration determined?
Funding levels and the number of awards are not fixed. NIH indicates that award size and project duration will vary depending on what applicants propose, and that total funding and the number of awards will depend on the quantity, quality, costs, and durations of applications received.
Is there a set budget cap listed in the summary provided?
No. In the information provided, the FOA frames funding as flexible and tied to scientific merit and program priorities rather than setting a single budget cap.
What types of organizations are eligible to apply?
Eligibility is broad and includes many categories of domestic organizations such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses and other for-profit organizations, state and local governments (including counties, cities or townships, special district governments, and independent school districts), public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations.
Are foreign institutions eligible to apply?
Yes. The announcement states that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The announcement states that eligible federal agencies may apply.
Are faith-based or community-based organizations permitted to apply?
Yes. The announcement states that faith-based or community-based organizations are permitted.
Is cost sharing or matching required?
No. The FOA indicates that no cost sharing or matching is required.
When was this FOA posted?
The FOA was posted on November 20, 2006.
Did the FOA have a single deadline or multiple receipt dates?
It used multiple receipt dates rather than a single deadline, meaning applications were accepted on recurring NIH submission cycles during the active period.
Is this specific announcement still active?
No. The archived date is June 1, 2009, indicating this specific announcement is no longer active, although similar initiatives may appear under newer NIH announcements.
What CFDA coverage is associated with this program?
The program spans several CFDA numbers associated with NIH research areas, including biomedical research and training and several cancer and alcohol research program listings, reflecting the cross-cutting relevance of liver development and regeneration across NIH missions and disease areas.
Where can applicants find the full official announcement?
NIH directs applicants to the complete announcement at http://grants.nih.gov/grants/guide/pa-files/PA-07-026.html.
Who is the contact for access or technical issues?
For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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