Opportunity Information: Apply for RFA HD 10 006
Apply for RFA HD 10 006
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Developmental Mechanisms of Human Structural Birth Defects (P01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 30, 2010 and posted on Jul 30, 2010.
- Applicants must submit their applications by Nov 30, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $900,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses State governments Public and State controlled institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) .
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The Developmental Mechanisms of Human Structural Birth Defects (P01) funding opportunity (RFA-HD-10-006) is a National Institutes of Health program project grant announcement issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Its central goal is to support tightly integrated, multidisciplinary research programs that explain how congenital structural malformations arise, with a particular emphasis on developmental biology and genetic mechanisms. The intent is to bring together basic science, translational research, and clinical investigation in a way that is genuinely interactive and synergistic, meaning the combined projects should accomplish more together than the same studies would in isolation.
A defining feature of this FOA is its required program structure. To control costs and keep projects focused, each P01 application is limited to three component research projects plus associated shared cores. Within those three projects, the FOA requires balance across the research spectrum: at least one component project must be basic research using an animal model system, and at least one component project must be clinical or translational in nature. The projects cannot be loosely related; they must be united by a clear central theme focused on a specific structural malformation or a coherent class of anomalies. Importantly, the chosen defect or defect class must be comparable across animal models and humans in a meaningful way, such as shared genetic causes, underlying developmental mechanisms, biological pathways, or observable phenotypes that are analogous or homologous between species. In practice, this pushes applicants to pick problems where animal model discoveries can be directly tied to human biology and where human observations can refine mechanistic hypotheses tested in models.
The award uses the NIH Program Project (P01) mechanism, which is designed for coordinated, multi-project research efforts supported by shared resources. The expectation is that cores (for example, administrative, data management, biostatistics, imaging, genomics, animal model services, or similar shared infrastructure) will enable the three projects to function as a cohesive program rather than separate labs operating in parallel.
In terms of funding, NICHD anticipated making two to three awards under this announcement. The FOA indicated total costs of up to $4,000,000 per year over a five-year project period across the competition, and it listed an award ceiling of $900,000 (as provided in the source data). The opportunity did not require cost sharing or matching. It was posted on July 30, 2010, with an application due date of November 30, 2010, and it was later archived on December 31, 2010.
Eligibility was broad and included public and private institutions of higher education, state governments, public and state-controlled institutions, nonprofits (including both 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), and for-profit organizations other than small businesses. The FOA also explicitly recognized a range of other eligible applicants and institution types, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), regional organizations, and eligible federal agencies. Administrative details and the full announcement were made available through the NIH grants website, with NIH Office of Extramural Research (OER) webmaster contact information provided for access or linking issues.
Overall, this opportunity was aimed at building compact but high-impact research teams that connect animal model developmental biology with human genetics and clinical/translational studies, all focused on understanding the origins of specific structural birth defects and accelerating progress toward biologically grounded insights that can inform diagnosis, risk assessment, and future interventions.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "The Developmental Mechanisms of Human Structural Birth Defects (P01)" and is identified as RFA-HD-10-006.
Which agency and NIH institute issued this announcement?
This is a National Institutes of Health (NIH) program project grant announcement issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What is the main goal of the FOA?
The central goal is to support tightly integrated, multidisciplinary research programs that explain how congenital structural malformations arise, with particular emphasis on developmental biology and genetic mechanisms.
What kind of research approach does NICHD want to see in applications?
The FOA is intended to bring together basic science, translational research, and clinical investigation in a way that is genuinely interactive and synergistic. The expectation is that the combined set of projects will accomplish more together than they would as separate, stand-alone efforts.
What grant mechanism is used for this opportunity?
The award uses the NIH Program Project (P01) mechanism, which is designed for coordinated, multi-project research efforts supported by shared resources (cores).
How many component research projects are allowed in a P01 application under this FOA?
Each P01 application is limited to three component research projects, along with associated shared cores.
Are there specific requirements for what the three projects must include?
Yes. Within the three projects, the FOA requires balance across the research spectrum:
- At least one component project must be basic research using an animal model system.
- At least one component project must be clinical or translational in nature.
Do the projects need to be closely related?
Yes. The component projects cannot be loosely connected. They must be united by a clear central theme focused on a specific structural malformation or a coherent class of anomalies.
What does it mean that the defect or defect class must be comparable across animal models and humans?
The FOA emphasizes that the chosen defect or class of defects should be meaningfully comparable between animal models and humans. Examples of meaningful comparability include shared:
- Genetic causes
- Underlying developmental mechanisms
- Biological pathways
- Observable phenotypes that are analogous or homologous between species
This encourages programs where animal model discoveries can be tied directly to human biology and where human observations can refine mechanistic hypotheses tested in models.
What are "cores" in a P01, and why are they important here?
Cores are shared resources and infrastructure that support all component projects and help the program function as a cohesive whole rather than separate labs working in parallel. The FOA gives examples such as:
- Administrative core
- Data management
- Biostatistics
- Imaging
- Genomics
- Animal model services
How many awards did NICHD anticipate making?
NICHD anticipated making two to three awards under this announcement.
What level of funding was described in the FOA?
The FOA indicated total costs of up to $4,000,000 per year over a five-year project period across the competition, and it listed an award ceiling of $900,000 (as provided in the source data).
Is cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
When was the opportunity posted, and when were applications due?
It was posted on July 30, 2010, and the application due date was November 30, 2010.
Is this funding opportunity still open?
No. The opportunity was later archived on December 31, 2010.
Who was eligible to apply?
Eligibility was broad and included:
- Public and private institutions of higher education
- State governments
- Public and state-controlled institutions
- Nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status)
- For-profit organizations other than small businesses
Were any specific institution types explicitly recognized as eligible?
Yes. The FOA explicitly recognized additional eligible applicants and institution types, including:
- Alaska Native and Native Hawaiian Serving Institutions
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Regional organizations
- Eligible federal agencies
What kinds of outcomes or impact is this FOA trying to accelerate?
This opportunity was aimed at building compact but high-impact research teams that connect animal model developmental biology with human genetics and clinical/translational studies, focused on understanding the origins of specific structural birth defects. The stated intent includes accelerating progress toward biologically grounded insights that can inform diagnosis, risk assessment, and future interventions.
Where were administrative details and the full announcement made available?
Administrative details and the full announcement were made available through the NIH grants website.
Who was listed as the contact for access or linking issues?
The FOA provided NIH Office of Extramural Research (OER) webmaster contact information for access or linking issues.
Browse more opportunities from the same category: Health Income Security and Social Services
Next opportunity: FY11 Announcement of Anticipated Availability of Funds for Family Planning Services Grants (Illinois, Chicago Area)
Previous opportunity: Nutrition and Alcohol Related Health Outcomes (R21)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA HD 10 006
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA HD 10 006) also looked into and applied for these:
| Funding Opportunity |
|---|
| NICHD Program Project Grant (P01) Apply for PAR 10 245 Funding Number: PAR 10 245 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Molecular Mechanisms of Adverse Metabolic Drug Effects in Children and Adolescents (R01) Apply for RFA HD 10 010 Funding Number: RFA HD 10 010 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $250,000 |
| Dual Purpose with Dual Benefit Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Species (R01) Apply for PAR 10 276 Funding Number: PAR 10 276 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Identifying and Understanding Effective Interventions for Orphans and Vulnerable Children Affected by HIV/AIDS (R01) Apply for RFA HD 10 017 Funding Number: RFA HD 10 017 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Preclinical Research on Model Organisms to Predict Treatment Outcomes for Disorders Associated with Intellectual and Developmental Disabilities (R01) Apply for PAR 11 038 Funding Number: PAR 11 038 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Treating Co Morbid Conditions in Adolescents with Intellectual and Developmental Disabilities (R01) Apply for PA 11 039 Funding Number: PA 11 039 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Treating Co Morbid Conditions in Adolescents with Intellectual and Developmental Disabilities (R03) Apply for PA 11 040 Funding Number: PA 11 040 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Treating Co Morbid Conditions in Adolescents with Intellectual and Developmental Disabilities (R21) Apply for PA 11 041 Funding Number: PA 11 041 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Specialized Cooperative Centers Program in Reproduction and Infertility Research (U54) Apply for RFA HD 12 169 Funding Number: RFA HD 12 169 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Outcome Measures for Use in Treatment Trials for Individuals with Intellectual and Developmental Disabilities (R01) Apply for PAR 11 045 Funding Number: PAR 11 045 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Indo US Collaborative Program on Low Cost Medical Devices (R03) Apply for PAR 11 044 Funding Number: PAR 11 044 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Mechanisms of Adverse Drug Reactions in Children (R01) Apply for PAR 11 051 Funding Number: PAR 11 051 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Mechanisms of Adverse Drug Reactions in Children (R03) Apply for PAR 11 052 Funding Number: PAR 11 052 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Studies in Neonatal Hypoglycemia (R03) Apply for PA 11 054 Funding Number: PA 11 054 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Studies in Neonatal Hypoglycemia (R01) Apply for PA 11 053 Funding Number: PA 11 053 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Studies in Neonatal Hypoglycemia (R21) Apply for PA 11 055 Funding Number: PA 11 055 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Mentored Patient Oriented Research Career Development Award in Muscular Dystrophy Research (K23) Apply for PA 11 076 Funding Number: PA 11 076 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award in Muscular Dystrophy Research (K99/R00) Apply for PA 11 078 Funding Number: PA 11 078 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award in Muscular Dystrophy Research (K08) Apply for PA 11 077 Funding Number: PA 11 077 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Specialized Centers in Research in Pediatric Developmental Pharmacology Program (U54) Apply for RFA HD 10 026 Funding Number: RFA HD 10 026 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $500,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA HD 10 006", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.