Opportunity Information: Apply for PA 10 241
Apply for PA 10 241
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Nutrition and Alcohol Related Health Outcomes (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.393 Cancer Cause and Prevention Research.
- This funding opportunity was created on Jul 30, 2010 and posted on Jul 30, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) For profit organizations other than small businesses Special district governments County governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Nutrition and Alcohol Related Health Outcomes (R21) is an NIH discretionary grant opportunity (Funding Opportunity Number PA 10 241) led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in partnership with the National Cancer Institute (NCI). The central focus is to support exploratory research that clarifies how nutrition interacts with alcohol use to shape health outcomes. The program is intentionally broad, aiming to spark new ideas and generate early evidence about nutritional factors that may influence the development of alcohol related conditions, protect against them, or improve prevention and treatment strategies.
The scientific scope emphasizes studies that examine associations between nutrition and alcohol related health outcomes in both humans and animal models. Applicants are encouraged to look at nutrition as a contributor to, or modifier of, a wide range of alcohol related issues, including alcohol dependence, psychiatric comorbidities, and both chronic and acute diseases. The announcement also highlights interest in organ function, organ damage, and related biological consequences of alcohol exposure, with nutrition framed as a potentially important driver of vulnerability, resilience, disease progression, and recovery. In practical terms, projects might explore how dietary patterns, nutrient deficiencies, supplementation, metabolism, or nutritional status affect alcohol related disease risks, or how alcohol use alters nutritional biology in ways that lead to harmful outcomes.
A notable feature of this opportunity is the flexibility in research approach. The FOA explicitly welcomes biomedical research, epidemiologic approaches, and intervention studies. That means applicants can propose mechanistic laboratory work, population based observational analyses, or early stage trials that test nutrition related strategies in the context of alcohol use and its consequences. Because this is an R21 mechanism, the intent is generally to fund exploratory or developmental projects that can establish feasibility, develop new methods, or generate preliminary data needed for larger future studies.
The award mechanism is the NIH Exploratory/Developmental Grant (R21). The funding listing includes an award ceiling of $275,000, and it notes that actual award size and project duration may vary depending on the proposed work. NIH also makes clear that the total number of awards and the total dollars ultimately committed depend on the mix of applications received, including their scientific quality, budgets, and timelines. This R21 opportunity runs in parallel with companion announcements of the same scientific scope that support other mechanisms: PA 10 239 (R01) and PA 10 240 (R03), giving applicants options depending on the maturity and scale of their proposed research.
Eligibility is broad and includes many types of organizations. Eligible applicants span public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non 501(c)(3) entities), for profit organizations (including small businesses and other for profit entities), and multiple levels of government such as state, county, city or township governments, and special district governments. The eligibility language also extends to tribal governments and tribal organizations, public housing authorities, independent school districts, and a range of mission focused institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs). The FOA also allows non U.S. entities (foreign organizations), regional organizations, faith based or community based organizations, and U.S. territories or possessions. Cost sharing or matching is not required, which lowers barriers for applicants who may not have additional funds to contribute.
From an administrative standpoint, this opportunity is cataloged under CFDA 93.273 (Alcohol Research Programs) and 93.393 (Cancer Cause and Prevention Research), reflecting the joint NIAAA and NCI interest and the potential overlap between alcohol, nutrition, and cancer related outcomes. The opportunity was posted on July 30, 2010, and the original and final closing date listed is September 7, 2013, with an archive date of October 8, 2013. The full announcement was made available through the NIH Grants Guide, and technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact listed in the notice.
Frequently Asked Questions (FAQs)
What is the "Nutrition and Alcohol Related Health Outcomes (R21)" opportunity?
Nutrition and Alcohol Related Health Outcomes (R21) is an NIH discretionary grant opportunity focused on exploratory research that clarifies how nutrition interacts with alcohol use to shape health outcomes. It is published as Funding Opportunity Number PA-10-241.
Which NIH Institutes are leading or partnering on this funding opportunity?
The opportunity is led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in partnership with the National Cancer Institute (NCI).
What is the main goal or central focus of this FOA?
The central focus is to support exploratory or developmental projects that generate early evidence and new ideas about nutritional factors that may influence the development of alcohol-related conditions, protect against them, or improve prevention and treatment strategies.
What types of research questions fit the scope of this program?
The scope is intentionally broad and emphasizes studies that examine how nutrition may contribute to, or modify, alcohol-related health outcomes. Examples of topic areas described include how dietary patterns, nutrient deficiencies, supplementation, metabolism, or nutritional status affect alcohol-related disease risks, as well as how alcohol use may alter nutritional biology in ways that lead to harmful outcomes.
Are studies in humans required, or are animal studies allowed?
Both are allowed. The scientific scope explicitly emphasizes research examining associations between nutrition and alcohol-related health outcomes in humans and in animal models.
What kinds of health outcomes are considered "alcohol-related" for this FOA?
The announcement highlights a wide range of alcohol-related issues, including alcohol dependence, psychiatric comorbidities, and both chronic and acute diseases. It also notes interest in organ function, organ damage, and biological consequences of alcohol exposure, with nutrition potentially affecting vulnerability, resilience, disease progression, and recovery.
Does the FOA encourage research on organ damage and biological consequences of alcohol exposure?
Yes. The FOA specifically highlights interest in organ function, organ damage, and related biological consequences of alcohol exposure, framing nutrition as a potentially important driver of vulnerability, resilience, disease progression, and recovery.
What research approaches are welcomed under this opportunity?
The FOA explicitly welcomes multiple approaches, including biomedical research, epidemiologic approaches, and intervention studies. This flexibility supports projects ranging from mechanistic laboratory work to population-based observational analyses and early-stage trials testing nutrition-related strategies in the context of alcohol use and its consequences.
What grant mechanism is used for this opportunity?
The award mechanism is the NIH Exploratory/Developmental Grant (R21).
What does it mean that this is an R21 mechanism?
As described in the opportunity summary, the R21 mechanism is intended to support exploratory or developmental projects. Typical aims include establishing feasibility, developing new methods, or generating preliminary data needed to support larger future studies.
What is the maximum funding amount listed for this R21?
The funding listing includes an award ceiling of $275,000.
Is the award size and project duration fixed?
No. The information provided notes that actual award size and project duration may vary depending on the proposed work.
How are the number of awards and total funding determined?
NIH indicates that the total number of awards and total dollars ultimately committed depend on the mix of applications received, including their scientific quality, budgets, and timelines.
Are there related opportunities for other project sizes or mechanisms?
Yes. This R21 opportunity runs in parallel with companion announcements of the same scientific scope supporting other mechanisms: PA-10-239 (R01) and PA-10-240 (R03). These provide options depending on the maturity and scale of the proposed research.
Who is eligible to apply?
Eligibility is broad and includes many organization types. Eligible applicants include public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) entities); for-profit organizations (including small businesses and other for-profit entities); and multiple levels of government (state, county, city or township, and special district governments).
Are tribal governments and tribal organizations eligible?
Yes. The eligibility language extends to tribal governments and tribal organizations.
Are schools and public housing authorities eligible?
Yes. The eligibility list includes independent school districts and public housing authorities.
Are mission-focused institutions (such as HBCUs or Hispanic Serving Institutions) eligible?
Yes. The FOA explicitly includes a range of mission-focused institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Can non-U.S. organizations apply?
Yes. The FOA allows non-U.S. entities (foreign organizations) and regional organizations, and it also includes U.S. territories or possessions.
Are faith-based or community-based organizations eligible?
Yes. The eligibility language includes faith-based or community-based organizations.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
What CFDA numbers are associated with this opportunity?
This opportunity is cataloged under CFDA 93.273 (Alcohol Research Programs) and CFDA 93.393 (Cancer Cause and Prevention Research), reflecting the joint NIAAA and NCI interest and overlap between alcohol, nutrition, and cancer-related outcomes.
When was this opportunity posted?
The opportunity was posted on July 30, 2010.
What were the closing date(s) and archive date listed?
The original and final closing date listed is September 7, 2013, and the archive date is October 8, 2013.
Where was the full announcement made available?
The full announcement was made available through the NIH Grants Guide.
Who was listed for technical access issues related to the announcement?
Technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact listed in the notice.
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