Opportunity Information: Apply for PAR 11 057
Apply for PAR 11 057
- The National Institutes of Health in the environment health income security and social services sector is offering a public funding opportunity titled "Developmental Pharmacology (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.242 Mental Health Research Grants 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Aug 7, 2013 and posted on Dec 3, 2010.
- Applicants must submit their applications by Aug 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $499,999.00 in funding.
- Eligible applicants include: Small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities State governments County governments City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Private institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Developmental Pharmacology (R01) funding opportunity (PAR-11-057) is an NIH discretionary grant program built around the standard Research Project Grant (R01) mechanism. It was issued jointly by several NIH Institutes: the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute of General Medical Sciences (NIGMS), the National Institute of Mental Health (NIMH), and the National Institute of Environmental Health Sciences (NIEHS). The central goal is to support multidisciplinary, investigator-initiated basic and translational research that improves understanding of how drug response changes across development, with a strong emphasis on ontogeny, meaning how biological systems mature over time from fetal life through adolescence. In practical terms, the program is looking for projects that explain why children and adolescents can process and respond to medicines differently than adults, and how those differences should shape dosing, safety assessments, and therapeutic strategies.
Scientifically, the opportunity prioritizes research on developmental changes in key biological determinants of pharmacology. That includes drug-metabolizing enzymes, drug transporters, receptors, and downstream signaling pathways, and how the activity and regulation of these systems vary across developmental windows. Studies may focus on fetal development, neonatal periods, infancy, childhood, and adolescence, and can be framed as basic mechanistic work or translational efforts that connect mechanistic findings to clinically meaningful outcomes. The multidisciplinary angle signals that the NIH expects proposals that draw on multiple areas such as developmental biology, pharmacokinetics and pharmacodynamics, molecular and systems pharmacology, genomics, pediatrics, toxicology, computational modeling, or disease-specific expertise (for example, cancer, mental health, or environmentally influenced conditions), depending on the research question.
From a funding and administrative standpoint, this is a grant (not a contract) under the R01 mechanism, with no cost sharing or matching requirement. The listed award ceiling is $499,999, indicating the anticipated maximum for budgets under this announcement as presented in the source data. The opportunity is categorized under broad federal activity areas that include environmental health and mental health, among others, and it is associated with multiple CFDA programs: 93.113 (Environmental Health), 93.242 (Mental Health Research Grants), 93.853 (Neurosciences and Neurological Disorders), 93.859 (Biomedical Research and Research Training), and 93.865 (Child Health and Human Development Extramural Research). The posting date was December 3, 2010, and the record reflects subsequent administrative dates (including a creation date of August 7, 2013) and an archival date of September 8, 2013, with the original closing date noted as May 7, 2014 and a current closing date shown as August 7, 2013 in the provided dataset.
Eligibility is broad and includes many organization types that commonly apply for NIH research grants. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government such as state, county, city or township, and special district governments. The announcement also explicitly includes tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and independent school districts. Additional eligible groups listed include Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), U.S. territories or possessions, faith-based or community-based organizations, regional organizations, eligible federal agencies, and non-U.S. entities (foreign organizations). This wide eligibility range reflects the NIH focus on supporting high-quality research wherever the expertise and infrastructure exist, including international collaborators or applicants when appropriate under NIH rules.
For applicants looking for the official announcement text and any institute-specific nuances, the provided additional information link points to the NIH Grants Guide page for PAR-11-057 at http://grants.nih.gov/grants/guide/pa-files/PAR-11-057.html. The contact information in the source data directs technical access or linking problems to the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs) - Developmental Pharmacology (R01) (PAR-11-057)
What is the Developmental Pharmacology (R01) funding opportunity (PAR-11-057)?
PAR-11-057 is an NIH discretionary grant opportunity that uses the standard Research Project Grant (R01) mechanism to support investigator-initiated research in developmental pharmacology, including both basic and translational studies.
What is the main goal of this opportunity?
The central goal is to support multidisciplinary research that improves understanding of how drug response changes across development, with a strong emphasis on ontogeny (how biological systems mature over time), from fetal life through adolescence. The program is intended to help explain why children and adolescents may process and respond to medicines differently than adults and how those differences should affect dosing, safety assessments, and therapeutic strategies.
Which NIH Institutes issued this funding opportunity?
This opportunity was issued jointly by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute of General Medical Sciences (NIGMS), the National Institute of Mental Health (NIMH), and the National Institute of Environmental Health Sciences (NIEHS).
What types of research does the program prioritize?
The program prioritizes research on developmental changes in key biological determinants of pharmacology, including drug-metabolizing enzymes, drug transporters, receptors, and downstream signaling pathways, and how their activity and regulation vary across developmental windows.
What developmental stages are within scope?
Studies may focus on fetal development, neonatal periods, infancy, childhood, and adolescence.
Does this opportunity support basic research, translational research, or both?
Both. Projects can be framed as basic mechanistic research or translational efforts that connect mechanistic findings to clinically meaningful outcomes.
What does "ontogeny" mean in the context of this opportunity?
Ontogeny refers to how biological systems develop and mature over time. In this program, the emphasis is on understanding how maturation from fetal life through adolescence affects drug metabolism, transport, receptor function, signaling, and overall drug response.
What scientific topics or biological systems are specifically highlighted?
The announcement highlights developmental changes in drug-metabolizing enzymes, drug transporters, receptors, and downstream signaling pathways, including changes in activity and regulation across development.
Is a multidisciplinary approach expected?
Yes. The opportunity emphasizes multidisciplinary projects, which may draw on fields such as developmental biology, pharmacokinetics (PK) and pharmacodynamics (PD), molecular and systems pharmacology, genomics, pediatrics, toxicology, computational modeling, or disease-specific expertise (for example, cancer, mental health, or environmentally influenced conditions), depending on the research question.
What funding mechanism is used?
The opportunity uses the NIH Research Project Grant (R01) mechanism.
Is this a grant or a contract?
This is a grant opportunity (not a contract).
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What is the listed award ceiling?
The listed award ceiling is $499,999, indicating the anticipated maximum budget level as presented in the source data.
What federal assistance program areas (CFDA) are associated with this opportunity?
The opportunity is associated with multiple CFDA programs: 93.113 (Environmental Health), 93.242 (Mental Health Research Grants), 93.853 (Neurosciences and Neurological Disorders), 93.859 (Biomedical Research and Research Training), and 93.865 (Child Health and Human Development Extramural Research).
What broad federal activity areas are referenced?
The opportunity is categorized under broad federal activity areas that include environmental health and mental health, among others.
When was this opportunity posted?
The posting date listed is December 3, 2010.
What closing dates are shown in the provided record?
The source data notes an original closing date of May 7, 2014, and also shows a current closing date as August 7, 2013. The record also reflects subsequent administrative dates, including a creation date of August 7, 2013 and an archival date of September 8, 2013.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government (state, county, city or township, and special district governments).
Are tribal entities eligible?
Yes. The eligibility list explicitly includes tribal governments and tribal organizations, as well as public housing authorities/Indian housing authorities.
Are independent school districts eligible?
Yes. Independent school districts are explicitly listed as eligible applicants.
Are minority-serving institutions included in eligibility?
Yes. The eligibility list includes Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included in the eligibility list.
Are regional organizations eligible?
Yes. Regional organizations are listed as eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included in the eligibility list.
Can foreign (non-U.S.) organizations apply?
Yes. The eligibility list explicitly includes non-U.S. entities (foreign organizations).
Where can applicants find the official NIH announcement text?
The additional information link provided points to the NIH Grants Guide page for PAR-11-057: http://grants.nih.gov/grants/guide/pa-files/PAR-11-057.html
Who should be contacted for technical access or linking problems?
The source data directs technical access or linking problems to the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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