Opportunity Information: Apply for PAR 08 215

  • The National Institutes of Health in the environment health income security and social services sector is offering a public funding opportunity titled "Developmental Pharmacology (R03)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.242 Mental Health Research Grants 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Dec 5, 2008 and posted on Jul 24, 2008.
  • Applicants must submit their applications by May 21, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Independent school districts Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Small businesses County governments Native American tribal governments (Federally recognized) Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Developmental Pharmacology (R03) funding opportunity (PAR 08 215) is an NIH discretionary grant program led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), along with other participating NIH Institutes, to support research in developmental pharmacology. The central goal is to advance basic and translational, investigator-initiated work that explains how normal growth and development (ontogeny) changes the way drugs are handled and how they act in the body. The opportunity places special emphasis on understanding how drug-metabolizing enzymes, transporters, receptors, and downstream signaling pathways vary across key stages of development, spanning fetal life through adolescence. In practical terms, the program is aimed at building better evidence for age-appropriate dosing, safety, and therapeutic effectiveness by accounting for biological differences that occur as children grow.

This announcement uses the NIH Small Research Grant (R03) mechanism, which is designed for smaller, tightly focused projects that can be completed relatively quickly with limited resources. The R03 mechanism is suited to pilot and feasibility studies, small self-contained projects, secondary analyses of existing datasets, and early work to develop or refine research methods and technologies. The intent is to help investigators generate foundational data or proof-of-concept findings that can clarify developmental mechanisms relevant to pharmacology and potentially position a project for larger follow-on funding. The FOA is part of a set of parallel announcements with the same scientific scope offered through other NIH mechanisms, specifically an R21 option (PAR 08 216) for exploratory/developmental projects and an R01 option (PAR 07 416) for full-scale research projects.

The opportunity is broadly open to many types of applicants, reflecting NIH-wide eligibility norms. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government (state, county, city/township, special district). It also explicitly includes tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a wide range of mission-specific institutional categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs). Foreign (non-U.S.) organizations, regional organizations, U.S. territories or possessions, federal agencies, and faith-based or community-based organizations are also listed among eligible entities, indicating an intent to allow participation from diverse research settings and communities. No cost sharing or matching is required.

Administratively, this FOA is associated with CFDA program areas that include Environmental Health (93.113), Mental Health Research Grants (93.242), and Child Health and Human Development Extramural Research (93.865), which signals the cross-cutting relevance of developmental pharmacology to multiple NIH missions. The opportunity was posted July 24, 2008, created December 5, 2008, and had an original and current closing date of May 21, 2010, with an archive date of June 21, 2010, meaning it is a historical announcement rather than an active competition today. Applicants seeking the original announcement details were directed to the NIH Grants Guide link (http://grants.nih.gov/grants/guide/pa-files/PAR-08-215.html). For access or technical issues, the contact point provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

Developmental Pharmacology (R03) (PAR-08-215) FAQs

1) What is the Developmental Pharmacology (R03) funding opportunity (PAR-08-215)?

PAR-08-215 is an NIH discretionary grant opportunity that uses the NIH Small Research Grant (R03) mechanism to support research in developmental pharmacology. It is led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) with other participating NIH Institutes.

2) What is the main goal of this program?

The central goal is to advance basic and translational, investigator-initiated research explaining how normal growth and development (ontogeny) changes how drugs are handled by the body and how drugs act in the body.

3) What developmental stages are emphasized in the scientific scope?

The announcement emphasizes variation across key stages of development spanning fetal life through adolescence.

4) What kinds of biological factors does the FOA emphasize?

It places special emphasis on understanding how drug-metabolizing enzymes, transporters, receptors, and downstream signaling pathways vary across development.

5) Why is developmental pharmacology important according to this FOA?

In practical terms, the program aims to build better evidence for age-appropriate dosing, safety, and therapeutic effectiveness by accounting for biological differences that occur as children grow.

6) What grant mechanism does this opportunity use?

This announcement uses the NIH Small Research Grant (R03) mechanism, intended for smaller, tightly focused projects that can be completed relatively quickly with limited resources.

7) What types of projects are typically appropriate for the R03 mechanism under this FOA?

R03 projects described as suitable include pilot and feasibility studies, small self-contained projects, secondary analyses of existing datasets, and early work to develop or refine research methods and technologies.

8) What is the intent of using an R03 for developmental pharmacology work?

The intent is to help investigators generate foundational data or proof-of-concept findings that clarify developmental mechanisms relevant to pharmacology and potentially position a project for larger follow-on funding.

9) Are there related NIH announcements with the same scientific scope but different mechanisms?

Yes. The FOA is part of a set of parallel announcements with the same scientific scope offered through other NIH mechanisms: an R21 option (PAR-08-216) for exploratory/developmental projects and an R01 option (PAR-07-416) for full-scale research projects.

10) Who leads this funding opportunity at NIH?

The opportunity is led by NICHD (Eunice Kennedy Shriver National Institute of Child Health and Human Development) along with other participating NIH Institutes.

11) What organizations are eligible to apply?

The announcement indicates broad eligibility consistent with NIH-wide norms. Eligible applicants include public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status, other than institutions of higher education), and for-profit organizations (including small businesses and other for-profit entities).

12) Are government entities eligible to apply?

Yes. Multiple levels of government are listed as eligible, including state, county, city/township, and special district governments.

13) Are tribal governments and tribal organizations eligible?

Yes. Tribal governments and tribal organizations are explicitly included, along with public housing authorities/Indian housing authorities.

14) Does the FOA explicitly include certain institution types such as MSIs and other mission-specific categories?

Yes. The eligible entity list explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and related categories.

15) Are foreign (non-U.S.) organizations eligible to apply?

Yes. Foreign (non-U.S.) organizations are listed among eligible entities.

16) Are U.S. territories or possessions eligible to apply?

Yes. U.S. territories or possessions are listed among eligible entities.

17) Are federal agencies eligible to apply?

Yes. Federal agencies are listed among eligible entities.

18) Are faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations are listed among eligible entities.

19) Is cost sharing or matching required?

No. The announcement states that no cost sharing or matching is required.

20) What CFDA program areas are associated with this FOA?

This FOA is associated with CFDA program areas including Environmental Health (93.113), Mental Health Research Grants (93.242), and Child Health and Human Development Extramural Research (93.865), signaling cross-cutting relevance to multiple NIH missions.

21) When was this opportunity posted and when did it close?

The opportunity was posted on July 24, 2008. It had an original and current closing date of May 21, 2010, and an archive date of June 21, 2010.

22) Is PAR-08-215 an active opportunity today?

Based on the provided dates (closing date in 2010 and archive date in 2010), it is a historical announcement rather than an active competition today.

23) Where can someone find the original NIH Grants Guide announcement page?

The original announcement details were directed to the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAR-08-215.html

24) Who is the contact for access or technical issues related to the announcement?

The contact provided for access or technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

25) What does "investigator-initiated" mean in the context provided?

In the context of this announcement, the research supported is described as investigator-initiated, meaning the projects are proposed by investigators and aligned to the FOA's developmental pharmacology scope.

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