Deep Sequencing and Haplotype Profiling of Mental Disorders (R01) | Apply Online

Opportunity Summary:

The NIH National Institute of Mental Health (NIMH) funding opportunity titled "Deep Sequencing and Haplotype Profiling of Mental Disorders (R01)" (Funding Opportunity Number PA-08-198) is designed to push psychiatric genetics beyond broad gene-hunting approaches and toward a more detailed, clinically useful understanding of how genomic variation contributes to mental disorders. The announcement is framed around the moment when early deliverables of the Human Genome Project made it realistic to connect comprehensive DNA sequence information to biological function and, ultimately, to diagnosis, prognosis, and treatment. In that context, NIMH is looking for research that makes practical, translational use of modern sequencing and genomic analysis to clarify the genetic architecture of mental illness, including how genomic structure and function interact with environmental factors.

A central scientific theme in this FOA is the idea of "disaggregating" a mental disorder into components of finite risk. In plain terms, the institute is encouraging study designs that break down what is often treated as a single diagnosis into more specific genetic and biological subcomponents, with the goal of identifying distinct contributing factors rather than one overly broad, averaged signal. The FOA explicitly welcomes large-scale studies and innovative analytical strategies that could produce incremental advances or even fundamentally new ways of thinking about psychiatric disease biology. The emphasis on potentially paradigm-shifting work signals that NIMH is open to proposals that rethink conventional case-control approaches, refine phenotypes, integrate new genomic measures, or otherwise make the genetic signals in mental disorders more interpretable and clinically meaningful.

On the research approach side, the announcement highlights deep sequencing and haplotype profiling as priority methods. Applications may propose cost-effective whole genome analysis technologies, as well as intensive sequencing and analysis of candidate genes or specific genomic regions. The FOA also makes clear that both family-based designs (for example, sequencing within pedigrees) and studies of unrelated individuals with mental disorders are within scope, which gives applicants flexibility to choose designs suited to rare variants, inherited patterns, de novo changes, or population-level association signals. In addition to generating data, the announcement encourages the development of new analytical methods and study designs for large-scale haplotype analysis, reflecting the need for improved tools to reconstruct and interpret the combination patterns of variants inherited together and to relate those patterns to psychiatric phenotypes.

This opportunity uses the NIH Research Project Grant (R01) mechanism. It is separate from, but runs in parallel with, another announcement of identical scientific scope (PA-08-199) that uses a Collaborative R01 structure. For applicants, this basically means PA-08-198 is the standard R01 route for a single project led by an investigator team, while the companion FOA exists for groups that want a more explicitly collaborative R01 arrangement under NIH rules. The scope and budget are intentionally flexible because the institute expects proposals to range from focused sequencing of key loci to much larger genomic efforts, and because sequencing and analytic costs can vary widely depending on sample size, depth, platforms, and computational strategy.

In terms of project structure, the maximum project period under this FOA is five years. The budget is not capped at a specific dollar amount, but applicants are expected to request funds that reflect the real needs of the proposed work and to justify those needs in line with NIH norms. The FOA does not require cost sharing or matching funds, which reduces barriers for academic and nonprofit groups and simplifies budgeting for multi-year genomic projects.

Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants span public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and various government entities (state, county, city/township, special district, and certain housing authorities), as well as independent school districts. The announcement also explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), tribal governments and tribal organizations (including those not federally recognized, as specified), U.S. territories and possessions, faith-based and community-based organizations, regional organizations, eligible federal agencies, and foreign (non-U.S.) entities. That wide eligibility aligns with the FOA's large-scale, methods-driven aims, since major sequencing and analytic efforts often involve diverse partnerships and specialized infrastructure.

Administratively, this is a discretionary grant opportunity in the health area, listed under CFDA 93.242 (Mental Health Research Grants). The posting date is July 24, 2008, with archival timing indicating it is no longer active (the archive date is February 7, 2010, and listed closing dates include January 7, 2010 and an earlier original closing date reference). The sponsor agency is the National Institutes of Health, and the program is specifically tied to NIMH priorities around translating genomic knowledge into advances for mental disorders. For full details, the announcement points applicants to the NIH grants guide link (PA-08-198) and provides NIH Office of Extramural Research (OER) webmaster contacts for access or technical linking problems.

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