Opportunity Information: Apply for PAR 08 216
Apply for PAR 08 216
- The National Institutes of Health in the environment health income security and social services sector is offering a public funding opportunity titled "Developmental Pharmacology (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.242 Mental Health Research Grants 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 24, 2008.
- Applicants must submit their applications by May 21, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Special district governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts Small businesses For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Developmental Pharmacology (R21) funding opportunity (PAR-08-216) is an NIH discretionary grant program led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), along with other participating NIH institutes, to support research focused on how drug response changes across childhood development. The central aim is to advance developmental pharmacology through multidisciplinary, investigator-initiated basic and translational studies, with a strong emphasis on ontogeny, meaning how biological systems mature from fetal life through adolescence. In practical terms, the program is looking for projects that explain how developmental stage affects drug metabolizing enzymes, drug transporters, receptors, and downstream signaling pathways, because these age-related differences can strongly influence drug exposure, effectiveness, and safety in pediatric populations.
This opportunity uses the NIH Exploratory/Developmental Grant mechanism (R21), which is generally intended for early-stage, innovative, or higher-risk projects that can generate proof-of-concept data or open new lines of investigation. The FOA is described as having the same scientific scope as two related companion announcements: PAR-08-215, which uses the smaller R03 mechanism, and PAR-07-416, which uses the more traditional R01 mechanism. That structure allows applicants to choose the grant type that best matches the maturity and scale of their project while staying within the same overall research theme of developmental pharmacology.
Funding details are intentionally flexible because NIH expects proposed studies to vary widely in methods, model systems, and scale. The announcement sets an award ceiling of $200,000, while also noting that both the number of awards and the total dollars ultimately distributed depend on the number of applications received and their scientific merit, duration, and budgets. There is no cost-sharing or matching requirement, which means applicants are not required to provide non-federal funds to receive an award.
Eligibility is broad and includes many categories of domestic and non-domestic organizations. Eligible applicants include state, county, city, township, and special district governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; small businesses and other for-profit entities; independent school districts; public housing authorities/Indian housing authorities; and multiple institution types that NIH often highlights for inclusion, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. The FOA also allows foreign organizations and other non-U.S. entities, regional organizations, U.S. territories or possessions, and certain tribal governments and tribal organizations, including some beyond federally recognized tribal governments as specified in the eligibility notes.
From an administrative standpoint, the opportunity was posted on July 24, 2008, with a listed original and current closing date of May 21, 2010, and an archive date of June 21, 2010, indicating the announcement is no longer active but remains available for reference. It falls under multiple CFDA program areas (93.113 Environmental Health, 93.242 Mental Health Research Grants, and 93.865 Child Health and Human Development Extramural Research), reflecting the cross-cutting relevance of developmental pharmacology to child health, environmental influences on biology, and mental health research. For full details, NIH referenced the complete FOA text at grants.nih.gov, and provided NIH Office of Extramural Research (OER) webmaster contacts for access or technical issues.
Developmental Pharmacology (R21) (PAR-08-216) - FAQs
What is the Developmental Pharmacology (R21) funding opportunity (PAR-08-216)?
PAR-08-216 is an NIH discretionary funding opportunity led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with other participating NIH institutes. It supports investigator-initiated basic and translational research on how drug response changes across childhood development.
What is the main scientific focus of this FOA?
The central focus is developmental pharmacology across the pediatric age spectrum, with emphasis on ontogeny (how biological systems mature from fetal life through adolescence) and how developmental stage influences drug exposure, effectiveness, and safety.
What does "ontogeny" mean in the context of this opportunity?
In this FOA, ontogeny refers to the maturation of biological systems over time, specifically from fetal life through adolescence, and how that maturation affects pharmacology and drug response.
What kinds of research questions is NIH looking for under this program?
The program is looking for projects that explain how developmental stage affects key determinants of drug response, including drug metabolizing enzymes, drug transporters, receptors, and downstream signaling pathways.
Why is developmental stage important for drug exposure, effectiveness, and safety?
Because enzymes, transporters, receptors, and signaling pathways can differ substantially by age, the same drug may lead to different levels of exposure, therapeutic effects, or adverse effects across pediatric developmental stages.
What grant mechanism does this opportunity use?
This opportunity uses the NIH Exploratory/Developmental Grant mechanism (R21).
What is an R21 grant generally intended to support?
R21 awards are generally intended for early-stage, innovative, or higher-risk research that can produce proof-of-concept data or open new lines of investigation.
Is this FOA limited to basic science, or does it include translational research?
It includes both basic and translational studies, and it emphasizes multidisciplinary approaches to advancing developmental pharmacology.
Are there related funding opportunities with the same scientific scope?
Yes. The FOA is described as having the same scientific scope as two companion announcements: PAR-08-215 (R03 mechanism) and PAR-07-416 (R01 mechanism). Applicants can choose the mechanism that best fits their project maturity and scale while staying within the same research theme.
How does this R21 relate to the companion R03 and R01 opportunities mentioned?
All three are aligned to the same overall developmental pharmacology theme, but they differ by grant mechanism: R03 is described as smaller, R21 supports exploratory/developmental projects, and R01 is described as more traditional.
What is the maximum award amount stated in the announcement?
The announcement sets an award ceiling of $200,000.
Is the number of awards guaranteed?
No. The number of awards and total dollars distributed depend on the number of applications received and their scientific merit, duration, and budgets.
Does this program require cost sharing or a matching contribution?
No. The announcement states there is no cost-sharing or matching requirement, so applicants are not required to provide non-federal funds to receive an award.
Who is eligible to apply?
Eligibility is broad and includes domestic and non-domestic organizations, including many types of government entities, higher education institutions, nonprofits, small businesses, and other for-profit entities, among others listed in the FOA summary.
Are U.S. government entities eligible applicants?
Yes. Eligible applicants include state, county, city, township, and special district governments.
Are colleges and universities eligible to apply?
Yes. Public and private institutions of higher education are eligible.
Are nonprofit organizations eligible, including those without 501(c)(3) status?
Yes. Nonprofit organizations with or without 501(c)(3) status are included among eligible applicants.
Are for-profit organizations eligible to apply?
Yes. Small businesses and other for-profit entities are listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are included as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Does the FOA encourage participation from specific institution types?
The FOA highlights institution types NIH often emphasizes for inclusion, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. The FOA allows foreign organizations and other non-U.S. entities, as well as regional organizations.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. Certain tribal governments and tribal organizations are eligible, including some beyond federally recognized tribal governments as specified in the eligibility notes.
When was this funding opportunity posted?
The opportunity was posted on July 24, 2008.
What was the closing date for applications?
The listed original and current closing date is May 21, 2010.
Is this funding opportunity still active?
No. The archive date is June 21, 2010, which indicates the announcement is no longer active and remains available for reference.
Which NIH institute leads this FOA?
It is led by NICHD (Eunice Kennedy Shriver National Institute of Child Health and Human Development), along with other participating NIH institutes.
What CFDA program areas are associated with this opportunity?
The FOA falls under multiple CFDA program areas: 93.113 Environmental Health, 93.242 Mental Health Research Grants, and 93.865 Child Health and Human Development Extramural Research.
What does it mean that this FOA is associated with multiple CFDA areas?
Based on the information provided, the multiple CFDA listings reflect the cross-cutting relevance of developmental pharmacology to child health, environmental influences on biology, and mental health research.
Where did NIH direct applicants to find the full FOA text?
NIH referenced the complete FOA text at grants.nih.gov.
Who was listed for access or technical issues related to the FOA?
NIH provided NIH Office of Extramural Research (OER) webmaster contacts for access or technical issues.
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