Opportunity Information: Apply for PA 15 037
Apply for PA 15 037
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Diabetes and Cardiovascular Disease in Older Adults (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Nov 19, 2014 and posted on Nov 18, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: City or township governments For profit organizations other than small businesses Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Small businesses State governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity "Diabetes and Cardiovascular Disease in Older Adults (R01)" (Funding Opportunity Number PA 15-037) supports research focused on how aging influences the development of diabetes mellitus (DM) and the cardiovascular disease (CVD) complications that often accompany it. The FOA is built around a central public health problem: older adults have a growing burden of diabetes, and when diabetes is present, cardiovascular outcomes are often more frequent and more severe. NIH is looking for projects that can clarify why this happens, how it should change the way clinicians detect and diagnose diabetes in later life, and which prevention and management strategies are most appropriate for older populations. The program explicitly welcomes a wide range of scientific approaches, including basic mechanistic work, clinical studies, and epidemiological and outcomes research, and it also allows studies in older-person cohorts as well as relevant animal models of aging.
The research scope is intentionally broad but highlights several priority areas. One priority is understanding the epidemiology of diabetes as people age, including why incidence and prevalence rise with advancing age and how these patterns may differ across racial and ethnic groups. Another emphasis is on identifying age-related biological mechanisms that predispose older adults to developing diabetes and, downstream, to developing cardiovascular complications. The FOA also calls for work that explains how aging changes the likelihood, presentation, and severity of cardiovascular outcomes among people who already have diabetes, recognizing that older adults may have different physiology, comorbidities, and treatment responses than younger populations. A fourth area encourages studies that test or refine age-specific approaches to prevention, screening, diagnosis, and management of diabetes in older adults, with a strong focus on strategies that reduce CVD complications.
A key expectation of this initiative is that funded studies will move the field toward more evidence-based, age-appropriate care. NIH is looking for results that can improve diagnostic criteria (for example, determining whether common thresholds or testing approaches perform differently in older adults), strengthen risk stratification (so clinicians can better predict who is most likely to develop complications), and inform interventions and clinical recommendations that are tailored to older adults. The ultimate goal is to prevent diabetes when possible, and when diabetes is present, to improve both short- and long-term outcomes related to cardiovascular complications in later life by grounding practice in better data on aging-related vulnerability.
Mechanistically, the FOA is interested in aging processes that might plausibly increase diabetes risk and worsen cardiovascular outcomes, such as age-associated changes in metabolism, inflammation, vascular function, body composition, physical function, and resilience to physiological stressors. On the clinical and outcomes side, relevant work could include studies of screening and diagnostic performance in older groups, comparative effectiveness of different treatment targets or medication strategies, and evaluation of how multimorbidity, frailty, polypharmacy, or functional limitations interact with diabetes management to influence cardiovascular events, disability, hospitalization, or mortality. On the epidemiology side, projects can examine population trends, disparities, and real-world outcomes using cohorts, registries, or other datasets, provided the focus remains on aging and older adults and on diabetes-CVD relationships.
This opportunity uses the NIH R01 grant mechanism, within the health research activity area (CFDA 93.866, Aging Research). Cost sharing or matching is not required. The FOA was posted in November 2014, with an original and current closing date listed as January 7, 2018, and an archive date of February 7, 2018, indicating it is no longer active as a current solicitation, though it remains useful as a reference point for the type of science NIH has sought in this area.
Eligibility is broad and includes many organization types: state, county, city or township, special district governments, independent school districts, public housing authorities/Indian housing authorities, public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, small businesses, and for-profit organizations other than small businesses. The FOA also allows applications from tribal governments (federally recognized and other than federally recognized) and tribal organizations, and it explicitly includes a wide range of mission-focused institutions such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities. Importantly, non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, foreign components as defined by NIH policy are allowed, and non-U.S. components of U.S. organizations are also eligible.
For applicants seeking the original announcement details, NIH provided an Additional Information link (http://grants.nih.gov/grants/guide/pa-files/PA-15-037.html). For technical access or linking issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Diabetes and Cardiovascular Disease in Older Adults (R01)" and the Funding Opportunity Number is PA 15-037.
What is the main public health problem this funding opportunity addresses?
This FOA focuses on the growing burden of diabetes mellitus (DM) in older adults and the fact that, when diabetes is present, cardiovascular disease (CVD) outcomes are often more frequent and more severe in later life. The goal is to generate evidence that helps explain why this occurs and how prevention, detection, diagnosis, and management should be adapted for older populations.
What is NIH looking for funded projects to clarify?
NIH is looking for research that clarifies why aging influences diabetes development and why CVD complications are more common or more severe in older adults with diabetes. It also seeks work that informs how clinicians should detect and diagnose diabetes in later life, and which prevention and management strategies are most appropriate for older adults, especially strategies that reduce CVD complications.
What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 research project grant mechanism.
What scientific approaches are welcomed under this FOA?
The FOA explicitly welcomes a wide range of approaches, including basic mechanistic studies, clinical studies, and epidemiological and outcomes research.
What types of study populations or models are allowed?
Projects may involve older-person cohorts and/or relevant animal models of aging, as long as the focus remains on aging, diabetes, and cardiovascular disease relationships.
How broad is the research scope, and what are the priority areas highlighted?
The scope is intentionally broad, but the FOA highlights several priority areas: (1) epidemiology of diabetes with aging, including patterns by advancing age and differences across racial and ethnic groups; (2) age-related biological mechanisms that predispose to diabetes and to downstream cardiovascular complications; (3) how aging changes the likelihood, presentation, and severity of cardiovascular outcomes among people with diabetes; and (4) age-specific approaches to prevention, screening, diagnosis, and management of diabetes in older adults, with emphasis on reducing CVD complications.
Does the FOA emphasize improving real-world clinical care for older adults?
Yes. A key expectation is that funded studies move the field toward more evidence-based, age-appropriate care for older adults, including improving diagnostic criteria, strengthening risk stratification, and informing interventions and clinical recommendations tailored to older populations.
What kinds of diagnostic questions does NIH want addressed for older adults?
The FOA is interested in whether common diagnostic thresholds or testing approaches perform differently in older adults, and how evidence could support improved diagnostic criteria that better fit older populations.
What is meant by "risk stratification" in the context of this FOA?
In this FOA, risk stratification refers to improving clinicians' ability to predict which older adults with diabetes are most likely to develop cardiovascular complications, so that prevention and management can be better targeted.
What aging-related biological mechanisms are of interest?
The FOA highlights aging processes that could plausibly increase diabetes risk and worsen cardiovascular outcomes, including age-associated changes in metabolism, inflammation, vascular function, body composition, physical function, and resilience to physiological stressors.
What clinical or outcomes research topics fit this FOA?
Relevant topics include evaluating screening and diagnostic performance in older groups; comparative effectiveness of different treatment targets or medication strategies; and assessing how multimorbidity, frailty, polypharmacy, or functional limitations interact with diabetes management to influence cardiovascular events, disability, hospitalization, or mortality.
What epidemiology-focused projects are considered relevant?
Projects may examine population trends, disparities, and real-world outcomes using cohorts, registries, or other datasets, provided they remain focused on aging/older adults and on diabetes-CVD relationships.
Does this FOA specifically encourage research on racial and ethnic differences?
Yes. One highlighted priority area is understanding how diabetes incidence and prevalence patterns with aging may differ across racial and ethnic groups.
Is cost sharing or matching required?
No. Cost sharing or matching is not required for this opportunity.
What is the CFDA number and program area listed for this opportunity?
The opportunity is within the health research activity area identified as CFDA 93.866 (Aging Research).
When was this FOA posted, and is it still active?
The FOA was posted in November 2014. It lists an original and current closing date of January 7, 2018, and an archive date of February 7, 2018. These dates indicate the solicitation is no longer active, though it may still be useful as a reference for the types of research NIH has sought in this area.
What organizations are eligible to apply?
Eligibility is broad and includes many organization types, such as: state, county, city or township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status; small businesses; and for-profit organizations other than small businesses.
Are tribal governments and tribal organizations eligible?
Yes. The FOA allows applications from tribal governments (federally recognized and other than federally recognized) and tribal organizations.
Does the FOA explicitly include applications from mission-focused institutions (for example, HBCUs or HSIs)?
Yes. The FOA explicitly includes a wide range of institutions such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply.
Are foreign components allowed under NIH policy?
Yes. Foreign components, as defined by NIH policy, are allowed under this FOA.
Can non-U.S. components of U.S. organizations participate?
Yes. Non-U.S. components of U.S. organizations are also eligible.
Where can applicants find the original NIH announcement details?
NIH provided an Additional Information link to the FOA at: http://grants.nih.gov/grants/guide/pa-files/PA-15-037.html
Who is the contact for technical access or linking issues related to the FOA page?
The contact listed for technical access or linking issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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