Opportunity Information: Apply for PA 15 038
Apply for PA 15 038
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Diabetes and Cardiovascular Disease in Older Adults (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Nov 19, 2014 and posted on Nov 18, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: Private institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education State governments Small businesses For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) County governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Diabetes and Cardiovascular Disease in Older Adults (R21) (Funding Opportunity Number PA 15 038) is an NIH discretionary grant program designed to support early stage, exploratory research on how aging influences diabetes mellitus (DM) and the cardiovascular disease (CVD) complications that often accompany it. The opportunity is centered on basic, clinical, and epidemiological outcomes research that can clarify why older adults are especially vulnerable to developing diabetes, how diabetes is detected and managed in later life, and why CVD outcomes may be more frequent or more severe in older people with diabetes. Studies may involve older human populations or appropriate animal models, with an emphasis on generating insights that can later translate into better prevention, diagnosis, risk prediction, and treatment approaches tailored to older adults.
The scientific scope highlights several priority directions. One focus is epidemiology: understanding the rising incidence and prevalence of diabetes with advancing age, including careful attention to racial and ethnic disparities that may shape risk, access to care, disease recognition, and outcomes. A second focus is mechanisms: identifying age-related biological or physiological changes that predispose older adults to diabetes and, downstream, to cardiovascular complications. A third focus is outcomes: determining how aging itself contributes to the increased incidence, progression, or severity of cardiovascular disease in older people who already have diabetes. A fourth focus is clinical strategy: developing and testing age-specific approaches for prevention, screening, diagnosis, and management of diabetes in older adults, including strategies to prevent or better manage cardiovascular complications. Across these areas, the underlying goal is to connect aging biology and real-world clinical outcomes so that research findings can guide practical improvements in care.
The FOA makes clear that NIH is looking for work that does more than document that older adults have higher risk; it aims to explain the aging-related mechanisms behind that risk and translate those explanations into evidence-based guidance. In practice, this means the funded studies are expected to inform more appropriate diagnostic criteria for older populations, improve risk stratification (so clinicians can better identify which older adults are most likely to develop diabetes or CVD complications), and strengthen intervention recommendations that prevent disease onset or improve both short- and long-term outcomes. The intent is to support research that can lead to more precise and clinically useful decision-making for older adults, rather than simply applying one-size-fits-all standards developed in younger populations.
From an administrative and eligibility standpoint, this is an NIH R21 mechanism, which typically supports exploratory and developmental projects that can generate proof-of-concept data or open new lines of inquiry. The award ceiling listed is $275,000, and there is no cost sharing or matching requirement. Eligible applicants are broad and include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses, for-profit organizations (including those other than small businesses), state and local governments (including city, county, special district, and independent school districts), public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The eligibility language also explicitly includes a wide range of institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and other minority-serving institutions, as well as faith-based and community-based organizations. Importantly, non-U.S. entities and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed consistent with NIH policy.
Key timeline details provided in the listing indicate the FOA was posted in November 2014, with an original and current closing date of January 7, 2018, and an archive date of February 7, 2018. The CFDA number associated with the program is 93.866 (Aging Research). The program is administered by the National Institutes of Health, and additional details were provided through the NIH grants guide link in the announcement. For access issues or technical problems with the posting, the contact point listed is the NIH Office of Extramural Research webmaster.
Frequently Asked Questions (FAQs)
What is the “Diabetes and Cardiovascular Disease in Older Adults (R21)†funding opportunity?
This opportunity (Funding Opportunity Number PA 15 038) is an NIH discretionary grant program using the R21 mechanism to support early-stage, exploratory research focused on how aging influences diabetes mellitus (DM) and the cardiovascular disease (CVD) complications that often occur alongside diabetes.
Which agency administers this program?
The program is administered by the National Institutes of Health (NIH).
What is the main purpose of this FOA?
The central purpose is to support research that explains why older adults are especially vulnerable to developing diabetes, how diabetes is detected and managed later in life, and why cardiovascular outcomes can be more frequent or more severe in older people with diabetes. The FOA emphasizes generating insights that can later translate into better prevention, diagnosis, risk prediction, and treatment approaches tailored to older adults.
What type of research does the FOA support?
The FOA supports basic, clinical, and epidemiological outcomes research. It is specifically framed around connecting aging biology with real-world clinical outcomes so findings can guide practical improvements in care for older adults.
Is this intended for exploratory or proof-of-concept work?
Yes. This is an NIH R21 mechanism, which typically supports exploratory and developmental projects that can generate proof-of-concept data or open new lines of inquiry.
What populations or models can be studied?
Studies may involve older human populations or appropriate animal models, with an emphasis on producing insights that can translate into improved clinical approaches for older adults.
What are the priority scientific areas highlighted in the FOA?
The scope highlights four major directions: (1) epidemiology of diabetes in older adults, including incidence/prevalence and disparities; (2) mechanisms, including age-related biological or physiological changes that predispose older adults to diabetes and cardiovascular complications; (3) outcomes, including how aging contributes to increased incidence, progression, or severity of CVD among older adults with diabetes; and (4) clinical strategy, including age-specific approaches for prevention, screening, diagnosis, and management of diabetes and CVD complications in older adults.
Does the FOA emphasize health disparities?
Yes. Within the epidemiology focus, it explicitly calls for careful attention to racial and ethnic disparities that may influence risk, access to care, disease recognition, and outcomes.
What kinds of deliverables or impacts is NIH looking for from funded studies?
NIH is looking for work that goes beyond documenting higher risk in older adults. The FOA emphasizes explaining aging-related mechanisms and translating those explanations into evidence-based guidance, such as informing more appropriate diagnostic criteria for older populations, improving risk stratification, and strengthening intervention recommendations to prevent disease onset or improve outcomes.
Is the FOA encouraging age-specific clinical approaches rather than applying standards developed in younger populations?
Yes. The intent is to support research that leads to more precise and clinically useful decision-making for older adults rather than one-size-fits-all standards developed in younger populations.
What is the award ceiling for this opportunity?
The listed award ceiling is $275,000.
Is cost sharing or matching required?
No. The listing states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes: public and private institutions of higher education; nonprofit organizations (including those with and without 501(c)(3) status); small businesses; for-profit organizations (including those other than small businesses); state and local governments (including city, county, special district, and independent school districts); public housing authorities/Indian housing authorities; and tribal governments and tribal organizations.
Are minority-serving institutions included in the eligible applicant types?
Yes. The eligibility language explicitly includes a wide range of institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and other minority-serving institutions.
Are faith-based or community-based organizations eligible?
Yes. The eligibility language explicitly includes faith-based and community-based organizations.
Can non-U.S. or foreign organizations apply?
Yes. Non-U.S. entities and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed consistent with NIH policy.
What are the key dates for this FOA?
The listing indicates the FOA was posted in November 2014. The original and current closing date is January 7, 2018, and the archive date is February 7, 2018.
What is the CFDA number associated with this program?
The CFDA number listed is 93.866 (Aging Research).
Where were additional details provided?
Additional details were provided through the NIH grants guide link referenced in the announcement.
Who is the contact for access issues or technical problems with the posting?
The contact point listed for access issues or technical problems is the NIH Office of Extramural Research webmaster.
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