Opportunity Information: Apply for PA 07 218
Apply for PA 07 218
- The National Institutes of Health in the education food and nutrition health income security and social services sector is offering a public funding opportunity titled "Diet Composition and Energy Balance (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.273 Alcohol Research Programs 93.393 Cancer Cause and Prevention Research 93.837 Cardiovascular Diseases Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Nov 12, 2009 and posted on Feb 14, 2007.
- Applicants must submit their applications by May 7, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments State governments Small businesses Native American tribal governments (Federally recognized) Private institutions of higher education County governments Independent school districts Public housing authorities/Indian housing authorities For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Diet Composition and Energy Balance (R01) opportunity (Funding Opportunity Number PA 07 218) is a National Institutes of Health (NIH) funding announcement inviting Research Project Grant (R01) applications focused on how diet composition influences energy balance. In practical terms, the program is looking for research that helps explain and test how the types and characteristics of what people (or animal models) eat affect key drivers of body weight and metabolic health, including appetite regulation, metabolism, and total energy expenditure. The scope is intentionally broad so applicants can propose anything from tightly controlled mechanistic work to real-world clinical interventions, as long as the central theme is the relationship between diet composition and energy balance.
A major emphasis of the announcement is welcoming both animal and human studies, and supporting both short-term and longer-term research designs. On the basic science side, the FOA encourages studies that dig into mechanisms, such as how changing micronutrients or macronutrients (for example, varying carbohydrate, fat, protein, fiber, specific fatty acids, or key vitamins/minerals) alters hunger and satiety signals, metabolic pathways, substrate utilization, thermogenesis, or energy expenditure. On the clinical and translational side, it invites projects that test diets differing in composition or structure and evaluate outcomes like weight loss and weight maintenance. The announcement specifically signals interest in diet features beyond just macronutrient ratios, including differences in nutrient absorption, dietary variety, and energy density, which can influence caloric intake and adherence even when diets appear similar on paper.
This FOA uses the NIH R01 mechanism, meaning it is intended for discrete, hypothesis-driven research projects with a clear plan, milestones, and well-justified budgets. The announcement does not set a single fixed award size or project length because it anticipates wide variation in what applicants might propose (for example, a shorter controlled feeding study versus a multi-year clinical trial, or a lab-based mechanistic study versus a community-based intervention). As a result, the number of awards and total dollars committed under this announcement are not pre-specified; they depend on the volume of submissions, scientific merit, project duration, and requested costs.
Eligibility is broad and includes many types of organizations that commonly apply for NIH grants. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a range of government entities (state, county, city/township, special districts, independent school districts, and certain housing authorities). Tribal organizations are eligible, including federally recognized tribal governments and other tribal entities. Importantly, foreign institutions are eligible to apply, and eligible U.S. federal agencies may also apply. The announcement also notes that faith-based and community-based organizations may apply, which can be relevant for studies that require community settings, recruitment infrastructure, or culturally tailored dietary interventions.
In terms of timing and administrative details, the opportunity was posted on February 14, 2007, with multiple receipt dates rather than a single one-time deadline, and the listing indicates a last noted closing date of May 7, 2010, with an archive date of June 7, 2010. The FOA is cataloged under multiple CFDA numbers spanning areas such as complementary and integrative health research, alcohol research programs, cancer prevention, cardiovascular research, neuroscience-related extramural programs, child health and human development, and aging research. That spread reflects how diet composition and energy balance connects to many disease areas and NIH institute missions. There is no cost sharing or matching requirement.
The full announcement is available through the NIH grants page at http://grants.nih.gov/grants/guide/pa-files/PA-07-218.html. For access or technical linking issues, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs): Diet Composition and Energy Balance (R01) - NIH (PA-07-218)
1) What is the name of this grant opportunity?
The opportunity is titled Diet Composition and Energy Balance (R01).
2) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-07-218.
3) Which federal agency is offering this opportunity?
This is a National Institutes of Health (NIH) funding announcement.
4) What type of grant mechanism is used?
This opportunity uses the NIH Research Project Grant (R01) mechanism.
5) What is the overall purpose of this FOA?
The FOA invites R01 applications focused on how diet composition influences energy balance. The intent is to support research that explains and tests how the types and characteristics of what people (or animal models) eat affect key drivers of body weight and metabolic health, including appetite regulation, metabolism, and total energy expenditure.
6) What does NIH mean by "diet composition" in this announcement?
Based on the description, "diet composition" includes the types and characteristics of what is eaten. Examples mentioned include modifying macronutrients (carbohydrate, fat, protein, fiber), specific fatty acids, and micronutrients (key vitamins/minerals). The FOA also highlights diet features beyond macronutrient ratios, such as nutrient absorption, dietary variety, and energy density.
7) What does NIH mean by "energy balance" in this announcement?
Within the provided description, energy balance relates to factors that shape body weight and metabolic health, including caloric intake, appetite and satiety signals, metabolic pathways, substrate utilization, thermogenesis, and total energy expenditure.
8) Is the scope narrow or broad?
The scope is described as intentionally broad. Applicants can propose studies ranging from tightly controlled mechanistic research to real-world clinical interventions, as long as the central theme is the relationship between diet composition and energy balance.
9) Are both human and animal studies allowed?
Yes. A major emphasis of the announcement is welcoming both animal and human studies.
10) Are both short-term and long-term studies allowed?
Yes. The FOA supports both short-term and longer-term research designs.
11) What kinds of basic science or mechanistic studies are encouraged?
The FOA encourages mechanistic studies examining how changing micro- or macronutrients alters physiological and metabolic drivers of energy balance. Examples named include effects on hunger and satiety signals, metabolic pathways, substrate utilization, thermogenesis, and energy expenditure.
12) What kinds of clinical or translational studies are encouraged?
On the clinical/translational side, the FOA invites projects that test diets differing in composition or structure and evaluate outcomes like weight loss and weight maintenance.
13) Does the FOA care only about macronutrient ratios (for example, low-fat vs. low-carb)?
No. The announcement specifically signals interest in diet features beyond ratios, including differences in nutrient absorption, dietary variety, and energy density. These factors can affect caloric intake and adherence even when diets appear similar on paper.
14) What kinds of outcomes or endpoints are implied by the description?
The description points to endpoints related to body weight and metabolic health and underlying drivers such as appetite regulation, metabolism, and total energy expenditure. It also mentions clinical outcomes including weight loss and weight maintenance.
15) Is this opportunity limited to one disease area or NIH institute?
No single disease area is indicated. The FOA is cataloged under multiple CFDA numbers spanning areas such as complementary and integrative health research, alcohol research programs, cancer prevention, cardiovascular research, neuroscience-related extramural programs, child health and human development, and aging research. This reflects that diet composition and energy balance connect to many disease areas and NIH missions.
16) Does the FOA specify a fixed award amount or fixed project duration?
No. The FOA does not set a single fixed award size or project length. It anticipates wide variation across study types (for example, shorter controlled feeding studies versus multi-year clinical trials, or lab-based mechanistic work versus community-based interventions).
17) Does NIH specify how many awards will be made or the total dollars committed?
No. The number of awards and total dollars are not pre-specified. They depend on factors such as volume of submissions, scientific merit, project duration, and requested costs.
18) What kinds of projects is the R01 mechanism intended for (as described here)?
As described, the R01 is intended for discrete, hypothesis-driven research projects with a clear plan, milestones, and well-justified budgets.
19) Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
20) Who is eligible to apply?
Eligibility is broad. Eligible applicants include:
- Public and private institutions of higher education
- Nonprofit organizations, including both 501(c)(3) and non-501(c)(3) entities
- For-profit organizations, including small businesses and other for-profits
- A range of government entities (state, county, city/township, special districts, independent school districts, and certain housing authorities)
- Tribal organizations, including federally recognized tribal governments and other tribal entities
- Foreign institutions
- Eligible U.S. federal agencies
- Faith-based and community-based organizations
21) Are foreign organizations allowed to apply?
Yes. The announcement notes that foreign institutions are eligible to apply.
22) Can for-profit organizations apply?
Yes. For-profit organizations (including small businesses and other for-profits) are listed as eligible applicants.
23) Can tribal entities apply?
Yes. Tribal organizations are eligible, including federally recognized tribal governments and other tribal entities.
24) Can faith-based or community-based organizations apply?
Yes. The announcement states that faith-based and community-based organizations may apply, which may be relevant for community settings, recruitment infrastructure, or culturally tailored dietary interventions.
25) When was this opportunity posted?
The opportunity was posted on February 14, 2007.
26) Does the FOA have a single deadline?
No. The opportunity indicates multiple receipt dates rather than a single one-time deadline.
27) What are the listed closing and archive dates?
The listing indicates a last noted closing date of May 7, 2010, and an archive date of June 7, 2010.
28) Where can applicants find the full announcement?
The full announcement is available on the NIH grants page at:
http://grants.nih.gov/grants/guide/pa-files/PA-07-218.html
29) Who should be contacted for website access or technical linking issues?
For access or technical linking issues, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
30) What are examples of diet-related variables specifically mentioned in the FOA description?
Examples explicitly mentioned include:
- Macronutrients: carbohydrate, fat, protein, fiber
- Specific fatty acids
- Micronutrients: key vitamins/minerals
- Nutrient absorption
- Dietary variety
- Energy density
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 218) also looked into and applied for these:
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