Opportunity Information: Apply for PA 07 219
Apply for PA 07 219
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Fragile X Pre mutation and Ovarian Function (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Feb 16, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education For profit organizations other than small businesses State governments City or township governments Native American tribal governments (Federally recognized) County governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Fragile X Pre mutation and Ovarian Function (R01) funding opportunity (PA-07-219) is an NIH grant announcement from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) that supports research on how the Fragile X premutation affects ovarian function. The central scientific focus is understanding and addressing ovarian dysfunction associated with the premutation, especially premature ovarian failure and early menopause. Projects can be basic, clinical, or translational in nature, and they may study these effects in women, in animal models, or in a combination of both, as long as the work is clearly aimed at clarifying mechanisms, consequences, or potential approaches relevant to ovarian health in premutation carriers.
The award mechanism is the standard NIH Research Project Grant (R01), which is intended for substantial, hypothesis-driven research programs that may involve multi-year, multi-aim studies. This FOA is described as running in parallel with another announcement of the same scientific scope that uses the R03 mechanism (PA-07-220). In practical terms, that means applicants with smaller, more limited, or pilot-style projects might consider the R03 route, while applicants proposing larger and more comprehensive research plans would typically align with the R01 mechanism under PA-07-219.
Funding levels and the number of awards are not fixed in advance. Instead, awards depend on the availability of NIH funds and the volume of strong applications received. Because proposed projects can vary widely in design (for example, laboratory-based mechanistic studies versus longitudinal clinical studies), the NIH anticipates that both the budget size and project duration will vary across funded grants. The total number of awards and total dollars awarded will ultimately be driven by factors such as scientific merit, requested costs, and how long each project is proposed to run.
From an administrative and eligibility standpoint, this is a discretionary grant opportunity within the Health category (CFDA 93.865: Child Health and Human Development Extramural Research), and it does not require cost sharing or matching. A broad range of applicant organizations are eligible, including higher education institutions (public and private), nonprofit organizations (including those with and without 501(c)(3) status, with the noted exception categories), for-profit organizations (including small businesses and other for-profits), independent school districts, and multiple levels of government entities (state, county, city/township, special district governments). Tribal governments and certain tribal organizations are also eligible. Importantly, foreign institutions are eligible to apply, eligible federal agencies may apply, and faith-based or community-based organizations are not excluded.
The opportunity was posted on February 16, 2007, and it used multiple receipt dates rather than a single deadline, meaning applications could be submitted on recurring standard NIH due dates during the active period of the announcement. The listing indicates an archive date of April 5, 2010, which signals that the specific announcement is no longer active in that original form, although similar topics may reappear under newer NIH funding announcements. The full announcement was historically available through the NIH Grants Guide webpage referenced in the listing, and general access or technical issues were routed to the NIH Office of Extramural Research (OER) webmaster contact provided.
Frequently Asked Questions (FAQs)
What is the funding opportunity?
This opportunity is the Fragile X Pre mutation and Ovarian Function (R01) funding opportunity announcement (FOA) PA-07-219. It is an NIH grant announcement from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What is the main research focus of PA-07-219?
The central focus is research on how the Fragile X premutation affects ovarian function. The goal is to better understand and address ovarian dysfunction associated with the premutation, with particular emphasis on premature ovarian failure and early menopause.
What types of studies does this FOA support (basic, clinical, translational)?
Projects may be basic, clinical, or translational in nature. The key requirement is that the proposed work is clearly aimed at clarifying mechanisms, consequences, or potential approaches relevant to ovarian health in Fragile X premutation carriers.
Are studies in humans required, or are animal models allowed?
The FOA allows studies in women, in animal models, or a combination of both. The work should be clearly tied to understanding ovarian function impacts related to the Fragile X premutation.
What grant mechanism is used for this opportunity?
The award mechanism is the standard NIH Research Project Grant (R01). This mechanism is typically used for substantial, hypothesis-driven research programs, often involving multiple aims over multiple years.
How does PA-07-219 relate to the R03 announcement PA-07-220?
This FOA (PA-07-219) is described as running in parallel with another announcement of the same scientific scope that uses the R03 mechanism (PA-07-220). In practical terms, applicants with smaller, more limited, or pilot-style projects might consider the R03 route, while larger and more comprehensive research plans would typically align with the R01 mechanism under PA-07-219.
Is the number of awards fixed?
No. The number of awards is not fixed in advance. Awards depend on the availability of NIH funds and the volume of strong applications received.
Are funding levels and project duration pre-set?
No. The NIH anticipates that both the budget size and project duration will vary across funded grants because proposed projects can differ widely in design (for example, laboratory-based mechanistic studies versus longitudinal clinical studies).
What factors influence how many awards are made and the total amount funded?
The total number of awards and total dollars awarded are driven by factors such as scientific merit, requested costs, and how long each project is proposed to run, along with NIH funds availability and application volume.
Does this opportunity require cost sharing or matching funds?
No. The listing states that cost sharing or matching is not required.
What is the CFDA number and category for this grant?
The opportunity is within the Health category and is associated with CFDA 93.865: Child Health and Human Development Extramural Research.
What kinds of organizations are eligible to apply?
A broad range of applicant organizations are eligible, including:
- Higher education institutions (public and private)
- Nonprofit organizations (including those with and without 501(c)(3) status, with noted exception categories)
- For-profit organizations (including small businesses and other for-profits)
- Independent school districts
- Government entities at multiple levels (state, county, city/township, special district governments)
- Tribal governments and certain tribal organizations
- Foreign institutions
- Eligible federal agencies
Are foreign institutions allowed to apply?
Yes. The information provided explicitly states that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The information provided states that eligible federal agencies may apply.
Are faith-based or community-based organizations excluded?
No. The information provided indicates that faith-based or community-based organizations are not excluded.
When was this opportunity posted, and how were due dates handled?
The opportunity was posted on February 16, 2007. It used multiple receipt dates rather than a single deadline, meaning applications could be submitted on recurring standard NIH due dates during the active period of the announcement.
Is PA-07-219 still active?
The listing indicates an archive date of April 5, 2010, which signals that the specific announcement is no longer active in its original form. Similar topics may reappear under newer NIH funding announcements.
Where was the full announcement historically available?
The full announcement was historically available through the NIH Grants Guide webpage referenced in the listing.
Who should be contacted for general access or technical issues related to the announcement listing?
General access or technical issues were routed to the NIH Office of Extramural Research (OER) webmaster contact provided in the listing.
Browse more opportunities from the same category: Health Income Security and Social Services
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 219) also looked into and applied for these:
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