Opportunity Information: Apply for PA 07 220
Apply for PA 07 220
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Fragile X Pre mutation and Ovarian Function (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Feb 16, 2007.
- Applicants must submit their applications by Mar 16, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education Small businesses Independent school districts Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Special district governments Private institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments City or township governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The grant opportunity titled "Fragile X Pre mutation and Ovarian Function (R03)" (Funding Opportunity Number PA-07-220) is a National Institutes of Health (NIH) funding announcement led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). It invites Small Research Grant (R03) applications that explore how the Fragile X premutation affects ovarian function. The scientific emphasis is on understanding and characterizing connections between the premutation and reproductive aging outcomes, especially premature ovarian failure (also commonly referred to as primary ovarian insufficiency) and early menopause. Projects may be basic, clinical, or translational in nature, and they can involve studies in women, animal models, or both, as long as the central question relates to ovarian function in the context of the Fragile X premutation.
This announcement uses the NIH R03 mechanism, which is designed for smaller-scope research efforts that can still produce meaningful advances or generate data needed for later, larger studies. The FOA explicitly highlights the kinds of projects the R03 is meant to support, such as pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, and work focused on developing or refining research methods or technologies. In practical terms, that means applicants can propose targeted studies that answer focused questions, test a new approach, establish proof-of-concept findings, or leverage already-collected samples or data to examine ovarian outcomes related to premutation status.
The R03 announcement runs in parallel with a separate, scientifically identical NIH opportunity that uses the R01 mechanism (PA-07-219). The parallel structure signals that NIH is supporting the same overall research theme at different scales: the R03 for compact, early-stage, or narrowly defined studies, and the R01 for larger, more comprehensive projects. Applicants choosing the R03 route should therefore shape proposals around realistic, contained aims that fit a small-grant framework while still clearly advancing understanding of Fragile X premutation-associated ovarian dysfunction.
From an administrative standpoint, this is a discretionary grant in the Health category, listed under CFDA 93.865 (Child Health and Human Development Extramural Research). No cost sharing or matching is required, which lowers barriers for many institutions because applicants are not expected to contribute institutional matching funds as a condition of the award.
Eligibility is broad and includes a wide range of organization types. Eligible applicants include public and private institutions of higher education, nonprofits both with and without 501(c)(3) status, small businesses and other for-profit organizations (excluding small businesses in the separate category), state and local governments (including county and city/township governments), independent school districts, special district governments, public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations. The eligibility section also specifies that foreign institutions may apply, eligible federal agencies may apply, and faith-based or community-based organizations are eligible as well. The overall effect of these eligibility rules is to open the competition to universities, hospitals, research institutes, government entities, and other research-capable organizations in the United States and abroad.
Key dates listed in the source information include a posted date of February 16, 2007, and multiple receipt dates, with an original closing structure based on repeated deadlines rather than a single cutoff. The current closing date shown in the record is March 16, 2010, with an archive date of April 16, 2010, indicating the opportunity is no longer active as written and has been archived. Applicants looking for a current version would typically need to search NIH’s current funding announcements for an updated FOA addressing Fragile X premutation and ovarian function or related topics.
The full announcement is linked through NIH’s grants website (http://grants.nih.gov/grants/guide/pa-files/PA-07-220.html). For access or linking issues, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV, which is meant for technical problems rather than scientific questions about project fit.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Fragile X Pre mutation and Ovarian Function (R03)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-07-220.
Which agency and institute lead this funding announcement?
This is a National Institutes of Health (NIH) funding announcement led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What research topic is this R03 opportunity focused on?
It invites Small Research Grant (R03) applications that explore how the Fragile X premutation affects ovarian function, with emphasis on understanding and characterizing connections between the premutation and reproductive aging outcomes.
What specific reproductive outcomes are highlighted?
The announcement particularly emphasizes outcomes related to reproductive aging, especially premature ovarian failure (also commonly referred to as primary ovarian insufficiency) and early menopause.
What types of research are allowed (basic, clinical, translational)?
Projects may be basic, clinical, or translational, as long as the central question relates to ovarian function in the context of the Fragile X premutation.
Are studies in humans, animals, or both allowed?
Yes. The announcement allows studies in women, animal models, or both, provided the core focus is ovarian function in relation to Fragile X premutation status.
What grant mechanism does this announcement use?
This opportunity uses the NIH R03 (Small Research Grant) mechanism, which is designed for smaller-scope research efforts.
What kinds of projects is the R03 mechanism intended to support?
The FOA highlights that R03 awards are meant to support projects such as:
- Pilot and feasibility studies
- Secondary analyses of existing datasets
- Small, self-contained research projects
- Research focused on developing or refining methods or technologies
What does the small-grant framing mean for how applicants should design their projects?
Applicants are expected to propose targeted, realistically contained aims that fit a small-grant framework, such as answering focused questions, testing a new approach, establishing proof-of-concept findings, or leveraging already-collected samples or data to evaluate ovarian outcomes related to premutation status.
Is there a related NIH opportunity for larger projects on the same topic?
Yes. This R03 announcement runs in parallel with a scientifically identical NIH opportunity using the R01 mechanism, listed as PA-07-219.
How do the parallel R03 and R01 opportunities differ based on the description provided?
They support the same overall research theme at different scales: the R03 is for compact, early-stage, or narrowly defined studies, while the R01 is intended for larger, more comprehensive projects.
What category and assistance listing information is provided?
This is described as a discretionary grant in the Health category and is listed under CFDA 93.865 (Child Health and Human Development Extramural Research).
Is cost sharing or matching required?
No. The information provided states that no cost sharing or matching is required.
What types of organizations are eligible to apply?
Eligibility is broad and includes many organization types, including:
- Public and private institutions of higher education
- Nonprofits with and without 501(c)(3) status
- For-profit organizations (including small businesses and other for-profits, as described)
- State and local governments (including county and city/township governments)
- Independent school districts
- Special district governments
- Public housing authorities / Indian housing authorities
- Native American tribal governments and tribal organizations
- Eligible federal agencies
- Faith-based and community-based organizations
- Foreign institutions
Are foreign institutions allowed to apply?
Yes. The eligibility information explicitly states that foreign institutions may apply.
Are faith-based or community-based organizations eligible?
Yes. The eligibility section specifies that faith-based and community-based organizations are eligible.
Are federal agencies eligible to apply?
Yes. The eligibility section indicates that eligible federal agencies may apply.
When was this FOA posted?
The posted date listed is February 16, 2007.
What are the key closing and archive dates shown for this opportunity?
The record shows a current closing date of March 16, 2010 and an archive date of April 16, 2010.
Is this funding opportunity still active?
No. Based on the closing and archive dates provided, the opportunity is no longer active as written and has been archived.
If this FOA is archived, what should applicants do to find a current version?
The provided information notes that applicants typically would need to search NIH's current funding announcements for an updated FOA addressing Fragile X premutation and ovarian function or closely related topics.
Where can the full announcement be found?
The full announcement is linked through NIH's grants website at: http://grants.nih.gov/grants/guide/pa-files/PA-07-220.html
Who should be contacted for technical problems accessing the announcement link?
For access or linking issues, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Is the listed contact intended for scientific questions about project fit?
No. The description states that the webmaster contact is meant for technical problems rather than scientific questions about whether a project fits the FOA.
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