DoD Amyotrophic Lateral Sclerosis Research Program Therapeutic Development Award | Apply Online

Opportunity Summary:

The DoD Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Development Award (TDA) is a U.S. Department of Defense funding opportunity designed to move potential ALS treatments forward through preclinical development. Its central purpose is to improve treatment options for amyotrophic lateral sclerosis by supporting research that is directly tied to developing or advancing therapeutic candidates. In practice, this means the program is looking for studies that generate concrete, decision-making data about a therapeutic agent, such as whether it is promising enough to justify further development. The award is explicitly restricted to ALS-focused work, and projects must stay tightly aligned with therapeutic development rather than general neuroscience or broad mechanistic exploration.

A key theme of the opportunity is that proposed projects should be empirical and product-driven. Applicants are encouraged to test both novel and existing agents in preclinical settings, with an emphasis on producing actionable outputs that can push a therapy along a development pathway. While hypothesis-driven research is not prohibited, the hypothesis must serve a therapeutic-development goal rather than basic science discovery for its own sake. The program anticipates that funded efforts will yield agents and/or datasets that enable meaningful advancement toward ALS therapeutics, such as preclinical efficacy signals, dose and regimen insights, pharmacology or toxicology indicators, or other development-enabling evidence. By contrast, basic science studies that do not directly inform therapeutic development are described as outside the intent of this mechanism.

The funding instrument is listed as a Cooperative Agreement/Grant under the Department of the Army (USAMRAA), reflecting the program’s placement within military medical research and development (CFDA 12.420). The opportunity category is discretionary, and it falls under science and technology and other research and development activities. The announcement projected an expected three awards, with an estimated total funding amount of $5,000,000. There is no cost-sharing or matching requirement stated for applicants, which means proposals are not expected to include institutional matching funds as a condition of eligibility.

Eligibility is described as “unrestricted,” meaning it is broadly open to different types of applicant entities, subject to any additional clarifications that may appear in the full announcement text. The posted date and creation date were May 27, 2009, and the application closing date was October 15, 2009, with an archive date of November 14, 2009. Importantly, the scope boundaries include a clear prohibition on clinical trials: even though the goal is to improve treatments, the work supported under this award must remain in the preclinical space and cannot be structured as a clinical trial.

For support and administrative questions, the announcement provides multiple help contacts, including assistance for accessing the full announcement (PA HELP at 301-619-7079 and cdmrp.pa@amedd.army.mil) and electronic submission support (eReceipt HELP at 301-682-5507, help@cdmrp.org), as well as the CDMRP Help Desk. Overall, this opportunity is best understood as a translational preclinical funding mechanism aimed at generating the kind of evidence and development-ready outputs that can meaningfully accelerate ALS therapeutic candidates, while excluding projects that are primarily basic research or any work that crosses into clinical trial territory.

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