Opportunity Information: Apply for RFA RM 09 007
Apply for RFA RM 09 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pilot Scale Libraries (PSL) for High Throughput Screening (P41)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on May 27, 2009 and posted on May 27, 2009.
- Applicants must submit their applications by Oct 1, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education Private institutions of higher education Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The Pilot Scale Libraries (PSL) for High Throughput Screening (P41) funding opportunity (RFA-RM-09-007) is a National Institutes of Health (NIH) discretionary grant program designed to strengthen the chemical library resources used for high throughput biological screening. It sits within the NIH Roadmap Molecular Libraries Program (MLP) and is specifically meant to support the creation, expansion, and delivery of chemical libraries that can be screened across a wide range of biological assays. In practical terms, the goal is to help supply well-designed sets of small molecules (and related compounds) that researchers can run through automated screening platforms to discover chemical probes and starting points for drug discovery. These libraries are intended for use by the Molecular Libraries Probe Production Centers Network (MLPCN), which is the broader network responsible for screening compounds and generating validated probes for the research community.
This opportunity uses the P41 mechanism, which NIH classifies as a Biomedical Research Resource grant. That mechanism is generally used when NIH wants to fund a capability, infrastructure, or resource that will serve a broad user community rather than only a single, narrow research project. For this particular announcement, the resource focus is the ability to generate pilot-scale chemical libraries suitable for high throughput screening efforts. Because the science and production approaches can differ widely from one applicant to another (for example, different chemistry platforms, synthesis workflows, compound classes, or quality control strategies), NIH notes that award size and project duration may vary depending on the scope of the proposed work.
In terms of funding scale, NIH indicated an intention to commit up to 2.5 million dollars in fiscal year 2010 for this program and anticipated making roughly 6 to 8 awards. The opportunity lists an award ceiling of 250,000 dollars, signaling that individual awards were expected to stay at or below that level, though the final distribution of funds would depend on the number of awards made and the budgets proposed. As with most federal research opportunities, awards were contingent on two main factors: the availability of appropriated funds and the presence of a sufficient number of strong, meritorious applications. NIH also emphasized that both the total number of awards and the total dollars actually awarded would ultimately reflect the quality, duration, and cost structure of the applications received.
Eligibility is broad and spans many organization types, reflecting NIHs interest in tapping expertise wherever strong library generation capabilities exist. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, small businesses, for-profit organizations other than small businesses, and nonprofit organizations both with and without 501(c)(3) status (other than institutions of higher education). The announcement also explicitly recognizes eligibility for several institution categories that NIH often highlights for inclusion, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and eligible federal agencies. The listing also notes that cost sharing or matching is not required, which typically lowers barriers to applying and helps organizations propose work based on scientific and operational need rather than an ability to contribute institutional funds.
Administrative details place the announcement in 2009, with a posted and creation date of May 27, 2009, and an original and current closing date of October 1, 2009. The archive date is November 1, 2009, meaning it is no longer active as a current competition, but the record remains as a reference point for how NIH structured this solicitation. The program is associated with CFDA number 93.310 (Trans-NIH Research Support), consistent with its Roadmap-style, NIH-wide research infrastructure emphasis. For applicants or readers needing the full text, NIH provided a link to the detailed FOA on the NIH grants site, along with contact instructions through the NIH Office of Extramural Research (OER) webmaster for access or technical issues.
Overall, the PSL (P41) opportunity was built to fund groups capable of producing high-quality, screening-ready chemical libraries at a pilot scale, with the explicit expectation that these libraries would feed into the MLPCN pipeline. The underlying public value proposition is that better and more diverse compound collections increase the odds of finding useful biological modulators, which can become widely shared chemical probes that accelerate basic research and early translational discovery across many disease and biology areas.
Frequently Asked Questions (FAQs)
What is the Pilot Scale Libraries (PSL) for High Throughput Screening (P41) funding opportunity?
The Pilot Scale Libraries (PSL) for High Throughput Screening (P41) opportunity (RFA-RM-09-007) is an NIH discretionary grant program intended to strengthen chemical library resources used for high throughput biological screening. It was part of the NIH Roadmap Molecular Libraries Program (MLP) and focused on supporting the creation, expansion, and delivery of chemical libraries that could be screened across many different biological assays.
What is the main goal of this program?
The goal is to help supply well-designed sets of small molecules (and related compounds) suitable for automated, high throughput screening. These screening-ready libraries are meant to help identify chemical probes and starting points for drug discovery by improving the quality and diversity of compounds available for screening.
How does this opportunity fit within NIH programs?
This opportunity sits within the NIH Roadmap Molecular Libraries Program (MLP) and is designed to support chemical library resources that contribute to high throughput screening efforts. It is specifically aligned with the broader Molecular Libraries Probe Production Centers Network (MLPCN), which screens compounds and produces validated probes for the research community.
What is the P41 mechanism and why was it used here?
The P41 mechanism is classified by NIH as a Biomedical Research Resource grant. It is generally used to fund capabilities, infrastructure, or resources that serve a broad user community rather than a single narrowly defined research project. In this case, the resource is the ability to generate pilot-scale chemical libraries suitable for high throughput screening.
What kinds of activities were expected to be supported by this grant?
The announcement emphasizes support for creating, expanding, and delivering chemical libraries that can be screened in a wide range of biological assays. It also notes that approaches could vary substantially by applicant, including differences in chemistry platforms, synthesis workflows, compound classes, and quality control strategies.
Who are the intended users or beneficiaries of the chemical libraries produced?
The libraries were intended for use by the Molecular Libraries Probe Production Centers Network (MLPCN), which is responsible for screening compounds and generating validated probes for broad use by the research community.
How many awards did NIH expect to make under this program?
NIH anticipated making approximately 6 to 8 awards.
How much total funding did NIH plan to commit?
NIH indicated an intention to commit up to $2.5 million in fiscal year 2010 for this program.
Was there an award ceiling for individual grants?
Yes. The opportunity listed an award ceiling of $250,000, signaling that individual awards were expected to stay at or below that level.
Were awards guaranteed at the stated funding levels?
No. As with most federal research opportunities, awards were contingent on the availability of appropriated funds and the receipt of a sufficient number of strong, meritorious applications. NIH also noted that the final number of awards and total dollars awarded would reflect application quality, project duration, and proposed costs.
Why might award size and project duration vary across recipients?
NIH noted that the science and production approaches could differ widely between applicants (for example, different chemistry platforms, synthesis workflows, compound classes, or quality control strategies). Because of those differences, award size and duration could vary depending on the scope of the proposed work.
What organizations were eligible to apply?
Eligibility was broad and included:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Small businesses
- For-profit organizations other than small businesses
- Nonprofit organizations with 501(c)(3) status (other than institutions of higher education)
- Nonprofit organizations without 501(c)(3) status (other than institutions of higher education)
- Eligible federal agencies
Did the announcement specifically mention any institution categories NIH wanted to include?
Yes. The announcement explicitly recognized eligibility for several institution categories often highlighted for inclusion, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and eligible federal agencies.
Was cost sharing or matching required?
No. The listing states that cost sharing or matching is not required.
When was this funding opportunity posted and when did it close?
The announcement has a posted and creation date of May 27, 2009. The original and current closing date listed is October 1, 2009.
Is this funding opportunity still active?
No. The archive date is November 1, 2009, which indicates it is no longer active as a current competition and remains available as a reference record.
What is the CFDA number associated with this program?
The program is associated with CFDA number 93.310 (Trans-NIH Research Support).
What is the broader public value or rationale behind funding pilot-scale chemical libraries?
The opportunity is built around the idea that better and more diverse compound collections increase the likelihood of finding useful biological modulators. Those modulators can become widely shared chemical probes that accelerate basic research and early translational discovery across many disease and biology areas.
Where could applicants find the full funding opportunity details or get help accessing the FOA?
NIH provided a link to the detailed FOA on the NIH grants site. For access or technical issues, the announcement referenced contact instructions through the NIH Office of Extramural Research (OER) webmaster.
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