Opportunity Information: Apply for W81XWH 10 ALSRP TDA
Apply for W81XWH 10 ALSRP TDA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Amyotrophic Lateral Sclerosis Therapeutic Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Apr 14, 2010 and posted on Apr 14, 2010.
- Applicants must submit their applications by Aug 4, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,800,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Amyotrophic Lateral Sclerosis (ALS) Therapeutic Development Award is a U.S. Department of the Army funding opportunity administered through USAMRAA that is focused specifically on moving potential ALS treatments forward through preclinical development. The core purpose is to support studies that generate practical, decision-driving evidence about therapeutic candidates, rather than purely exploratory biology. Projects are expected to be empirical and product driven, meaning the work should be organized around advancing a drug, biologic, or other therapeutic approach toward the next developmental milestone. A hypothesis-driven framework can be included, but the central emphasis must remain on therapeutics and on producing results that directly inform development pathways.
The opportunity is structured to fund preclinical assessment, which typically includes activities such as testing candidate agents in relevant in vitro or animal models, evaluating efficacy signals, characterizing pharmacology, dosing, and potential safety considerations, and producing data packages that make a candidate more ready for later-stage development. The program explicitly anticipates that the agents and/or the datasets generated through funded projects will help accelerate advancement of ALS therapeutics, implying an expectation that deliverables will be actionable and suitable for guiding subsequent development, partnerships, or future funding steps.
This announcement was released under Funding Opportunity Number W81XWH-10-ALSRP-TDA and is categorized as discretionary funding within science and technology and other research and development. Awards may be made either as grants or cooperative agreements, indicating that some projects could involve substantial involvement or coordination with the funding agency beyond what is typical for a standard grant, depending on the specific award mechanism used.
The total estimated funding available under this announcement is $4.8 million, with an anticipated two awards expected to be made. There is no cost sharing or matching requirement, which reduces barriers for applicants who may not have institutional funds to contribute. Eligibility is listed as unrestricted, meaning the competition is broadly open to applicant types, subject to any additional clarifications in the full announcement.
Key administrative dates for this particular cycle include a posted and created date of April 14, 2010, with an original and current closing date of August 4, 2010. The opportunity archive date is September 3, 2010, reflecting that this is a past funding cycle, though the program concept and structure can still be useful for understanding what the DoD ALS program tends to prioritize.
For support issues related to accessing the full announcement or submitting materials, the contact points provided include PA HELP at 301-619-7079 and cdmrp.pa@amedd.army.mil, as well as eReceipt HELP at 301-682-5507 and help@cdmrp.org, with the CDMRP Help Desk also referenced for assistance.
FAQs: DoD ALS Therapeutic Development Award (W81XWH-10-ALSRP-TDA)
What is the DoD ALS Therapeutic Development Award?
The DoD Amyotrophic Lateral Sclerosis (ALS) Therapeutic Development Award is a U.S. Department of the Army funding opportunity (administered through USAMRAA) designed to move potential ALS treatments forward through preclinical development.
What is the main purpose of this award?
The core purpose is to support studies that generate practical, decision-driving evidence about therapeutic candidates. The focus is on work that directly informs development pathways for ALS treatments rather than purely exploratory biology.
What kinds of projects are a good fit for this program?
Projects are expected to be empirical and product driven, organized around advancing a drug, biologic, or other therapeutic approach toward the next developmental milestone. While a hypothesis-driven framework can be included, the central emphasis must remain on therapeutics and on producing results that directly inform development decisions.
Is this funding for basic biology or exploratory research?
The opportunity emphasizes practical therapeutic advancement and decision-driving evidence. It is not centered on purely exploratory biology as a primary aim.
What stage of development does this award support?
This opportunity is structured to fund preclinical assessment, with the intent of advancing ALS therapeutic candidates toward later-stage development readiness.
What preclinical activities are typically included under this award?
Preclinical assessment typically includes testing candidate agents in relevant in vitro or animal models, evaluating efficacy signals, characterizing pharmacology, exploring dosing, considering potential safety issues, and producing data packages that make a candidate more ready for subsequent development.
What kinds of deliverables does the program expect?
The program anticipates that funded work will generate actionable outputs, such as agents and/or datasets that can accelerate advancement of ALS therapeutics. Deliverables are expected to be suitable for guiding next development steps, partnerships, or future funding efforts.
Does the award require results that directly guide development decisions?
Yes. The emphasis is on generating practical evidence that is decision-driving for therapeutic development pathways, rather than results that are only descriptive or exploratory.
What is the funding opportunity number (FOA number)?
The announcement was released under Funding Opportunity Number W81XWH-10-ALSRP-TDA.
Which agency administers this opportunity?
It is a U.S. Department of the Army funding opportunity administered through USAMRAA.
How is this opportunity categorized?
It is categorized as discretionary funding within science and technology and other research and development.
What award mechanisms may be used?
Awards may be made either as grants or as cooperative agreements.
What is a cooperative agreement in this context?
The announcement indicates that some projects may involve substantial involvement or coordination with the funding agency beyond what is typical for a standard grant, depending on the specific mechanism used.
How much total funding was estimated to be available under this announcement?
The total estimated funding available is $4.8 million.
How many awards were anticipated?
Approximately two awards were anticipated for this announcement.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement for this opportunity.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning the competition is broadly open to applicant types, subject to any additional clarifications in the full announcement.
When was this funding opportunity posted?
The posted/created date for this cycle was April 14, 2010.
What was the application closing date?
The original and current closing date listed for this cycle was August 4, 2010.
Is this an active opportunity?
The opportunity archive date is September 3, 2010, which indicates this is a past funding cycle. Even so, the description can still be useful for understanding what the DoD ALS program tends to prioritize.
Who can I contact for help accessing the full announcement or submitting materials?
For support, the announcement lists PA HELP at 301-619-7079 and cdmrp.pa@amedd.army.mil, and eReceipt HELP at 301-682-5507 and help@cdmrp.org. The CDMRP Help Desk is also referenced for assistance.
What types of assistance do the listed help contacts provide?
The contacts provided are specifically for support issues related to accessing the full announcement or submitting application materials (including eReceipt support).
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Previous opportunity: DoD Amyotrophic Lateral Sclerosis Therapeutic Idea Award
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