Opportunity Information: Apply for W81XWH 10 ALSRP TIA
Apply for W81XWH 10 ALSRP TIA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Amyotrophic Lateral Sclerosis Therapeutic Idea Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Apr 14, 2010 and posted on Apr 14, 2010.
- Applicants must submit their applications by Aug 4, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,920,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Amyotrophic Lateral Sclerosis (ALS) Therapeutic Idea Award is a Department of the Army funding opportunity created to spark genuinely new, early-stage therapeutic concepts for ALS. Its core purpose is to help researchers generate impactful preliminary data and open up new directions for developing novel ALS treatments. The program is explicitly aimed at conceptually innovative work that may be high risk but has the potential for high reward, meaning proposals can be exploratory and unconventional as long as they are scientifically grounded and designed to move the field toward meaningful therapeutic advances.
This award mechanism emphasizes the importance of a well-formulated, testable hypothesis supported by a strong scientific rationale. In practice, that means the project should not be a vague exploration or a general platform development effort without a clear ALS therapeutic question. Instead, applicants are expected to present a focused research plan that can produce interpretable results and provide a credible pathway toward therapeutic development, even if that pathway is still at an early, proof-of-concept stage. The intent is to fund ideas that could lead to critical discoveries or major progress in ALS therapeutics, rather than incremental extensions of established approaches.
Administratively, this opportunity was offered under Funding Opportunity Number W81XWH-10-ALSRP-TIA and was categorized as a discretionary program supporting science, technology, and other research and development activities. Funding was provided through grants and cooperative agreements, with an estimated total funding amount of $1,920,000 and an expectation of making about three awards. There was no cost sharing or matching requirement, which means applicants were not required to contribute additional non-federal funds as a condition of receiving an award.
Eligibility was listed as unrestricted, indicating it was open to essentially any type of applicant organization, subject to any clarifications that may have appeared in the full announcement under additional eligibility information. The administering agency was the Department of the Army, specifically USAMRAA, and the program was associated with CFDA number 12.420 (Military Medical Research and Development). The announcement was originally posted on April 14, 2010, with an application closing date of August 4, 2010, and it was later archived on September 3, 2010.
For applicant support and logistics, the announcement provided several help contacts: assistance accessing the full announcement through PA HELP at 301-619-7079 or cdmrp.pa@amedd.army.mil, and electronic submission support through eReceipt HELP at 301-682-5507 or help@cdmrp.org, along with the CDMRP Help Desk. Overall, the opportunity was structured to back bold, hypothesis-driven ALS therapeutic ideas at a stage where targeted funding can help determine whether a novel approach is promising enough to justify further development.
FAQs: DoD Amyotrophic Lateral Sclerosis (ALS) Therapeutic Idea Award
What is the DoD ALS Therapeutic Idea Award?
The DoD Amyotrophic Lateral Sclerosis (ALS) Therapeutic Idea Award is a Department of the Army funding opportunity designed to spark genuinely new, early-stage therapeutic concepts for ALS. It is intended to help researchers generate impactful preliminary data and open up new directions for developing novel ALS treatments.
What is the main purpose of this award?
The core purpose is to support conceptually innovative ALS therapeutic ideas so investigators can produce interpretable, proof-of-concept style data that may enable future therapeutic development. The program is positioned to help validate whether a novel approach is promising enough to justify further work.
What type of research is the program looking for?
The program is explicitly aimed at innovative, early-stage therapeutic concepts for ALS. It favors ideas that are scientifically grounded and designed to move the field toward meaningful therapeutic advances, including projects that may be exploratory or unconventional.
Does the program allow high-risk, high-reward proposals?
Yes. The award mechanism emphasizes high risk but potentially high reward work, as long as the proposal is scientifically grounded and structured to drive progress toward ALS therapeutic advances.
Do applicants need a hypothesis?
Yes. A well-formulated, testable hypothesis supported by a strong scientific rationale is emphasized. The project should be focused and designed to generate interpretable results.
Are general platform development projects a fit for this award?
Not if they lack a clear ALS therapeutic question. The opportunity indicates projects should not be vague explorations or general platform development efforts without a focused, testable ALS therapeutic hypothesis and a plan that yields interpretable outcomes.
What does the program mean by "therapeutic idea" in practice?
Based on the description provided, a therapeutic idea should be a conceptually innovative approach tied to a specific ALS therapeutic question, backed by scientific rationale, and supported by a research plan capable of producing preliminary data that informs therapeutic development.
Is this award intended for incremental extensions of existing approaches?
No. The intent is to fund ideas that could lead to critical discoveries or major progress in ALS therapeutics, rather than incremental extensions of established approaches.
What is the Funding Opportunity Number (FON) for this program?
The Funding Opportunity Number listed is W81XWH-10-ALSRP-TIA.
Which agency administers the award?
The administering agency is the Department of the Army, specifically USAMRAA.
What CFDA number is associated with this opportunity?
The program is associated with CFDA number 12.420, Military Medical Research and Development.
What type of funding instrument was used?
Funding was provided through grants and cooperative agreements.
How much total funding was estimated for this opportunity?
The estimated total funding amount was $1,920,000.
About how many awards were expected?
The opportunity indicated an expectation of making about three awards.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement, meaning applicants were not required to contribute additional non-federal funds as a condition of receiving an award.
Who was eligible to apply?
Eligibility was listed as unrestricted, meaning it was open to essentially any type of applicant organization, subject to any clarifications that may have appeared in the full announcement under additional eligibility information.
When was the opportunity posted and when did it close?
The announcement was originally posted on April 14, 2010, and the application closing date was August 4, 2010.
Is this opportunity still open?
No. The announcement was later archived on September 3, 2010.
What was the program category?
It was categorized as a discretionary program supporting science, technology, and other research and development activities.
Where could applicants get help accessing the full announcement?
Assistance accessing the full announcement was provided through PA HELP at 301-619-7079 or by email at cdmrp.pa@amedd.army.mil.
Where could applicants get help with electronic submission?
Electronic submission support was provided through eReceipt HELP at 301-682-5507 or by email at help@cdmrp.org, along with the CDMRP Help Desk.
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