Opportunity Information: Apply for W81XWH 14 BCRP BREAKTHROUGH12
Apply for W81XWH 14 BCRP BREAKTHROUGH12
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer Breakthrough Award Levels 1 and 2" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Mar 28, 2014 and posted on Mar 28, 2014.
- Applicants must submit their applications by May 28, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $39,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 30 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Breast Cancer Breakthrough Award Levels 1 and 2 (Funding Opportunity Number W81XWH 14 BCRP BREAKTHROUGH12) is a U.S. Department of the Army/USAMRAA funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) that aims to support breast cancer research with genuine breakthrough potential. The central priority is impact: proposed projects must be positioned to make a major difference in breast cancer, speeding progress toward improved prevention, detection, treatment, or other meaningful outcomes for people with breast cancer or those at risk. The program is not looking for small, incremental steps. Instead, applicants are expected to clearly explain how the work could lead to a substantial advance, and to spell out a realistic pathway toward clinical impact, even if direct clinical outcomes will not be achieved within the project period.
A key feature of this announcement is that it offers two funding levels tailored to the maturity and scope of a research idea. Funding Level 1 is designed for innovative, high-risk/high-reward concepts that are still in the earliest stages. These projects are meant to open up new directions or create entirely new avenues of investigation, with a strong emphasis on proof of concept. Importantly, preliminary data are not required at Level 1, which makes it a fit for bold ideas that are scientifically compelling but not yet well supported by existing results. Funding Level 2 is intended for work that is more developed and already backed by preliminary data. Level 2 projects should be positioned to make significant progress toward clinical translation, and where applicable, should include demonstration of efficacy in in vivo models. In other words, Level 2 expects a stronger evidence base and a clearer translational trajectory, while still requiring that the anticipated advance be substantial rather than incremental. Applicants are responsible for choosing the level that best matches their project, and the announcement notes that higher Levels 3 and 4 exist but are competed under a different program announcement.
Collaboration is actively encouraged through an optional Partnering PI structure. Under this option, two principal investigators can apply together as an Initiating PI and a Partnering PI, with each PI receiving a separate award. While they have different submission requirements, both investigators are expected to play meaningful roles in shaping and executing the project, including contributing to core elements like the project narrative and statement of work. The program stresses that each PI should bring distinct, clearly defined contributions, whether they come from similar fields or different disciplines. New collaborations are welcomed but not mandatory. What matters is that the application makes a convincing case that the partnership materially strengthens the science and that the work is better done together than as two independent efforts. To keep collaborations substantive, the opportunity discourages individuals from serving as a Partnering PI on multiple submissions unless those applications clearly address different research questions.
The opportunity also places emphasis on building a capable research team. The PI or PIs are expected to assemble personnel with the right mix of expertise and breast cancer-relevant experience to carry out the work successfully. In addition, the program encourages, though does not require, involvement of consumer advocates for applications at Levels 1 and 2. These consumer advocates are meant to serve as informed lay representatives who have personally been diagnosed with breast cancer and are active in a breast cancer advocacy organization. Their potential roles can include helping shape the research question, contributing to study design, participating in oversight, advising on recruitment, and assisting with evaluation or other meaningful project functions. The guidance also sets boundaries to maintain independence: consumer advocates cannot be employees of the applicant or participating organizations, and their participation should not be tied to employment. They are expected to have strong awareness of current breast cancer issues and sufficient background or training to contribute productively in a research setting.
From an administrative standpoint, this is a discretionary funding opportunity in the science and technology/research and development category, using grant and cooperative agreement instruments. The solicitation anticipated about 30 awards, with an estimated total funding amount of $39,000,000. There is no cost sharing or matching requirement, and eligibility is described as unrestricted (open to any type of entity), subject to any additional eligibility clarifications in the full announcement. The original posting date was March 28, 2014, with a closing date of May 28, 2014, and an archive date of June 27, 2014. For assistance accessing the full announcement, the contact listed is the CDMRP Help Desk (301-682-5507, help@eBRAP.org).
Frequently Asked Questions (FAQs)
What is the DoD Breast Cancer Breakthrough Award Levels 1 and 2?
It is a U.S. Department of the Army/USAMRAA funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) focused on breast cancer research with genuine breakthrough potential. The opportunity is identified as: DoD Breast Cancer Breakthrough Award Levels 1 and 2, Funding Opportunity Number W81XWH 14 BCRP BREAKTHROUGH12.
What is the main goal or priority of this opportunity?
The central priority is impact. Proposed projects must be positioned to make a major difference in breast cancer by accelerating progress toward improved prevention, detection, treatment, or other meaningful outcomes for people with breast cancer or those at risk.
What kind of research is this program looking for?
The program is focused on projects with breakthrough potential rather than small, incremental advances. Applicants are expected to explain how the work could lead to a substantial advance and to describe a realistic pathway toward clinical impact, even if direct clinical outcomes will not be reached during the project period.
What does the announcement mean by a "realistic pathway toward clinical impact"?
Applications are expected to spell out how the research could translate into meaningful clinical progress (for example, prevention, detection, treatment, or other outcomes), even if the work will not produce direct clinical results within the project timeframe.
What are the funding levels available under this announcement?
This announcement offers two funding levels: Funding Level 1 and Funding Level 2. Each level is intended for a different stage of idea maturity and translational readiness.
What is Funding Level 1 designed to support?
Funding Level 1 is designed for innovative, high-risk/high-reward concepts in the earliest stages. These projects are intended to open new directions or create new avenues of investigation, with a strong emphasis on proof of concept.
Is preliminary data required for Funding Level 1?
No. Preliminary data are not required at Funding Level 1, making it suitable for scientifically compelling ideas that are not yet strongly supported by existing results.
What is Funding Level 2 designed to support?
Funding Level 2 is intended for more developed work that is already backed by preliminary data. Level 2 projects should be positioned to make significant progress toward clinical translation.
Does Funding Level 2 have any specific expectations regarding models or evidence?
Yes. Funding Level 2 expects a stronger evidence base and a clearer translational trajectory. Where applicable, projects should include demonstration of efficacy in in vivo models.
Who chooses whether to apply to Level 1 or Level 2?
Applicants are responsible for selecting the level that best matches their project based on maturity, evidence base, and translational readiness.
Are there other Breakthrough Award levels beyond Levels 1 and 2?
Yes. The announcement notes that higher Levels 3 and 4 exist, but those are competed under a different program announcement.
Does this opportunity encourage collaboration?
Yes. Collaboration is actively encouraged through an optional Partnering PI structure.
What is the Partnering PI option?
The Partnering PI option allows two principal investigators to apply together as an Initiating PI and a Partnering PI. Under this structure, each PI receives a separate award, and both investigators are expected to play meaningful roles in shaping and executing the project.
Do the Initiating PI and Partnering PI have different submission requirements?
Yes. The announcement indicates that the two PIs have different submission requirements, while still requiring that both contribute to core elements such as the project narrative and statement of work.
What does the program expect from a collaboration under the Partnering PI option?
Each PI should bring distinct, clearly defined contributions. The application should make a convincing case that the partnership materially strengthens the science and that the work is better done together than as two independent efforts.
Are new collaborations required?
No. New collaborations are welcomed but not mandatory. The key requirement is demonstrating that the partnership adds meaningful scientific value.
Can someone serve as a Partnering PI on multiple applications?
The opportunity discourages individuals from serving as a Partnering PI on multiple submissions unless the applications clearly address different research questions.
What are the expectations for the research team?
The PI (or PIs) is expected to assemble personnel with the appropriate mix of expertise and breast cancer-relevant experience needed to successfully conduct the proposed work.
Are consumer advocates included in this opportunity?
Yes. The program encourages, but does not require, involvement of consumer advocates for applications at Funding Levels 1 and 2.
Who qualifies as a consumer advocate for this program?
Consumer advocates are described as informed lay representatives who have personally been diagnosed with breast cancer and are active in a breast cancer advocacy organization. They should have strong awareness of current breast cancer issues and sufficient background or training to contribute productively in a research setting.
What roles can consumer advocates play on a project?
Potential roles include helping shape the research question, contributing to study design, participating in oversight, advising on recruitment, and assisting with evaluation or other meaningful project functions.
Are there restrictions on consumer advocate independence or employment?
Yes. Consumer advocates cannot be employees of the applicant or participating organizations, and their participation should not be tied to employment.
What type of funding opportunity is this (administratively)?
It is described as a discretionary funding opportunity in the science and technology/research and development category, using grant and cooperative agreement instruments.
How many awards were anticipated and what was the estimated total funding?
The solicitation anticipated about 30 awards, with an estimated total funding amount of $39,000,000.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is described as unrestricted (open to any type of entity), subject to any additional eligibility clarifications in the full announcement.
What are the key dates listed for this opportunity?
The original posting date was March 28, 2014. The closing date was May 28, 2014. The archive date was June 27, 2014.
Who can be contacted for help accessing the full announcement?
The contact listed is the CDMRP Help Desk at 301-682-5507 or help@eBRAP.org.
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