Opportunity Information: Apply for W81XWH 14 BCRP BREAKTHROUGH34
Apply for W81XWH 14 BCRP BREAKTHROUGH34
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer Breakthrough Award Levels 3 and 4" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Mar 28, 2014 and posted on Mar 28, 2014.
- Applicants must submit their applications by Aug 15, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $40,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Breast Cancer Breakthrough Award Levels 3 and 4 (Funding Opportunity Number W81XWH-14-BCRP-BREAKTHROUGH34) is a U.S. Army Medical Research Acquisition Activity (USAMRAA) funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program (BCRP). It is designed to back breast cancer research that is positioned to produce genuine breakthroughs rather than small, incremental steps. The central expectation is impact: proposed work should have clear potential to substantially change the field and accelerate progress toward ending breast cancer. Even when the immediate outcomes are not clinical, applications are expected to spell out a credible pathway showing how the work could ultimately translate into clinical impact for people who have breast cancer or who are at risk.
This announcement focuses specifically on the higher-scope project categories, Funding Levels 3 and 4. The program explicitly recognizes that breakthrough research can come in different sizes and stages of development, from advanced translational efforts to large, practice-changing initiatives. The applicant (Principal Investigator, or PI) is responsible for choosing the funding level that best matches the project scope. (Separate program guidance covers Funding Levels 1 and 2 under a different announcement.) In practical terms, Level 3 is aimed at advanced translational studies that are mature enough to support near-term clinical investigation; appropriately designed small-scale clinical trials are allowed at this level. Level 4 is reserved for large-scale efforts intended to transform and revolutionize clinical management and/or prevention of breast cancer, with near-term clinical impact expected. Because Level 4 projects are inherently complex and resource-intensive, the opportunity emphasizes that PIs should already have experience successfully leading large-scale projects. A special review-related requirement also applies to Level 4: an invited oral presentation to the BCRP Integration Panel is required as part of application review, meaning applicants must be prepared for an additional, live evaluation step beyond the written submission.
The award mechanism allows either grants or cooperative agreements, reflecting that some projects may involve more active program involvement depending on scope and execution needs. The opportunity was posted March 28, 2014, with an application deadline of August 15, 2014, and an estimated total funding pool of $40,000,000. The program anticipated making about eight awards. The assistance listing/CFDA number associated with the program is 12.420 (Military Medical Research and Development). Cost sharing or matching is not required, which lowers administrative and financial barriers for applicants and lets scientific merit and impact drive competitiveness.
Eligibility is described as unrestricted, meaning the competition is broadly open to many entity types, subject to any clarifications in the full announcement. A notable structural feature is the Partnering PI Option, which is meant to encourage meaningful, productive collaborations rather than superficial multi-investigator arrangements. Under this option, two PIs participate: an Initiating PI and a Partnering PI. Each PI receives a separate award, and while their submission requirements differ, both are expected to contribute substantially to core parts of the application, including the project narrative and the statement of work. The program expects each PI to bring distinct expertise or capabilities that strengthen the science and improve the likelihood of achieving breakthrough-level impact. Collaborations can be new or established, but the application must clearly justify why the work is stronger together than it would be as separate, parallel projects. To keep the partnering structure focused and authentic, the program discourages someone from serving as a Partnering PI on multiple applications unless those applications clearly address different research questions.
For applicants needing help accessing the full announcement or navigating submission systems, the CDMRP Help Desk is the primary support channel (301-682-5507; help@eBRAP.org).
FAQs: DoD Breast Cancer Breakthrough Award Levels 3 and 4 (W81XWH-14-BCRP-BREAKTHROUGH34)
What is this funding opportunity?
This opportunity is the DoD Breast Cancer Breakthrough Award Levels 3 and 4, Funding Opportunity Number W81XWH-14-BCRP-BREAKTHROUGH34. It is offered by the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program (BCRP).
What is the main goal of the Breakthrough Award?
The central goal is to fund breast cancer research positioned to produce genuine breakthroughs rather than small, incremental advances. The core expectation is strong impact: the proposed work should have clear potential to substantially change the field and accelerate progress toward ending breast cancer.
Is clinical impact required even if the research is not immediately clinical?
Yes. Even if the immediate outcomes are not clinical, applications are expected to present a credible pathway explaining how the work could ultimately translate into clinical impact for people who have breast cancer or who are at risk.
Which funding levels are covered by this announcement?
This announcement focuses specifically on the higher-scope project categories, Funding Levels 3 and 4. (Separate program guidance covers Funding Levels 1 and 2 under a different announcement.)
How should the Principal Investigator (PI) choose between Level 3 and Level 4?
The PI is responsible for selecting the funding level that matches the project scope. Level 3 targets advanced translational studies mature enough to support near-term clinical investigation, while Level 4 targets large-scale efforts expected to transform and revolutionize clinical management and/or prevention with near-term clinical impact.
What types of projects are appropriate for Funding Level 3?
Level 3 is intended for advanced translational studies that are sufficiently mature to support near-term clinical investigation. Appropriately designed small-scale clinical trials are allowed at this level.
What types of projects are appropriate for Funding Level 4?
Level 4 is reserved for large-scale, complex efforts intended to transform and revolutionize clinical management and/or prevention of breast cancer, and near-term clinical impact is expected.
Does Level 4 have any special PI experience expectations?
Yes. Because Level 4 projects are inherently complex and resource-intensive, the opportunity emphasizes that the PI should already have experience successfully leading large-scale projects.
Is there any additional review step for Level 4 applications?
Yes. Level 4 includes a special review-related requirement: an invited oral presentation to the BCRP Integration Panel is required as part of the application review. Applicants should be prepared for an additional live evaluation step beyond the written submission.
What award mechanisms are available under this opportunity?
The mechanism allows either grants or cooperative agreements. This reflects that some projects may require more active program involvement depending on the project scope and execution needs.
When was this opportunity posted and what was the application deadline?
The opportunity was posted on March 28, 2014. The application deadline was August 15, 2014.
How much funding was expected to be available, and how many awards were anticipated?
The estimated total funding pool was $40,000,000, and the program anticipated making about eight awards.
What is the assistance listing (CFDA) number for this program?
The assistance listing/CFDA number associated with the program is 12.420 (Military Medical Research and Development).
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning the competition is broadly open to many entity types, subject to any clarifications in the full announcement.
What is the Partnering PI Option?
The Partnering PI Option is a structure designed to encourage meaningful, productive collaborations rather than superficial multi-investigator arrangements. Under this option, two PIs participate: an Initiating PI and a Partnering PI.
How does the Partnering PI Option work in terms of awards?
Each PI receives a separate award. While submission requirements differ between the two roles, both PIs are expected to contribute substantially to core parts of the application, including the project narrative and the statement of work.
What does the program expect from collaborations under the Partnering PI Option?
The program expects each PI to bring distinct expertise or capabilities that strengthen the science and improve the likelihood of achieving breakthrough-level impact. Collaborations can be new or established, but the application must clearly justify why the work is stronger together than as separate, parallel projects.
Can someone serve as a Partnering PI on multiple applications?
The program discourages an individual from serving as a Partnering PI on multiple applications unless those applications clearly address different research questions.
Where can applicants get help accessing the full announcement or navigating submission systems?
Applicants can contact the CDMRP Help Desk for support at 301-682-5507 or help@eBRAP.org.
Browse more opportunities from the same category: Science and Technology and other Research and Development
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