Opportunity Information: Apply for W81XWH 12 BCRP IMPT
Apply for W81XWH 12 BCRP IMPT
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Breast Cancer Impact Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Feb 23, 2012 and posted on Feb 23, 2012.
- Applicants must submit their applications by Aug 15, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $15,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DOD Breast Cancer Impact Award is a funding opportunity run through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), under the Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program (BCRP). Its purpose is to support breast cancer research projects ranging from small to large scale that tackle major scientific or clinical problems in breast cancer. The central theme is impact: proposed studies should aim to fundamentally change what is known or what is possible in breast cancer prevention, detection, or treatment, and move the field meaningfully closer to ending the disease rather than producing incremental advances.
A key priority for this award is research that goes after breast cancer issues that remain poorly understood but have high clinical importance. The announcement explicitly highlights topics such as prevention, susceptibility (risk and underlying drivers), recurrence, and metastasis. In other words, projects are expected to confront gaps that hold the field back, especially where solving the problem could translate into fewer new cases, fewer relapses, or fewer deaths. The program is open to a wide range of approaches and does not restrict applicants to a single scientific lane, as long as the research question is substantial and the plan is compelling.
The award is designed to accommodate projects from any discipline or a combination of disciplines, including basic laboratory research, translational work that bridges lab findings to patient care, clinical research (including clinical trials), behavioral research, and epidemiology. Impact can be near term or long term, but it must be significant and clearly non-incremental. Applicants are expected to explicitly explain why the proposed work would have an unusually large effect on breast cancer outcomes, such as reducing incidence, reducing recurrence, or lowering mortality. This requirement places a strong burden on the Principal Investigator to make the case that the work is not just interesting or well designed, but genuinely transformative if successful.
Another major requirement is that the proposed research must be grounded in solid evidence. Applications need to be based on sound overall research and be fully supported by preliminary data and/or published reports. Practically, this means the program is not meant for early, speculative ideas without support; it favors proposals that already have a credible foundation and are ready to be executed at a level that could produce field-changing results.
The Impact Award also encourages collaboration through a formal Partnering PI Option. Under this structure, two Principal Investigators can apply together in a way that results in separate awards for each PI while still submitting a single, jointly developed application. One investigator serves as the Initiating PI and the other as the Partnering PI, and while they have different submission requirements, both are expected to contribute meaningfully to the unified project. The partners can come from similar or very different disciplines, but they must bring distinct strengths, and the application must explain why doing the work together is essential and superior to two separate efforts. New collaborations are welcomed but not required, and the emphasis is on demonstrating a productive, well-justified partnership that strengthens the ability to answer the research question.
From an administrative standpoint, this opportunity was posted February 23, 2012, with an original and final closing date of August 15, 2012, and an archive date of September 14, 2012. It used grant and cooperative agreement funding instruments, was categorized under Science and Technology and other Research and Development, and was associated with CFDA 12.420 (Military Medical Research and Development). The estimated total funding was $15,000,000 with an expected five awards, and it did not require cost sharing or matching. Eligibility is listed as unrestricted, meaning it was broadly open to different types of applicant organizations, subject to any additional eligibility clarifications in the full announcement. For access issues or questions, the listed point of contact was the CDMRP Help Desk (301-682-5507, help@cdmrp.org).
Frequently Asked Questions (FAQs): DOD Breast Cancer Impact Award (CDMRP BCRP)
What is the DOD Breast Cancer Impact Award?
The DOD Breast Cancer Impact Award is a breast cancer research funding opportunity administered by the Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA), under the Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program (BCRP). It supports breast cancer research projects that aim to produce major scientific or clinical impact.
What is the main goal or theme of this award?
The central theme is impact. Proposed studies are expected to fundamentally change what is known or what is possible in breast cancer prevention, detection, or treatment, and to move the field meaningfully closer to ending the disease rather than delivering incremental advances.
What kinds of breast cancer problems does the award prioritize?
The announcement highlights high-importance issues that remain poorly understood, specifically including prevention, susceptibility (risk and underlying drivers), recurrence, and metastasis. The intent is to push applicants toward addressing major gaps that limit progress, especially where solutions could lead to fewer new cases, fewer relapses, or fewer deaths.
What types of research approaches are allowed?
The award is designed to accommodate projects from any discipline or combinations of disciplines. It explicitly allows basic laboratory research, translational research, clinical research (including clinical trials), behavioral research, and epidemiology, as long as the project’s question is substantial and the plan is compelling.
Does the award require the research to be immediately applicable (near-term impact)?
No. Impact may be near term or long term. However, it must be significant and clearly non-incremental, and applicants are expected to justify why the work would have an unusually large effect on breast cancer outcomes if successful.
How does the program define or expect applicants to demonstrate "impact"?
Applications are expected to explain why the proposed work would be transformative, such as by reducing breast cancer incidence, reducing recurrence, or lowering mortality. The burden is on the Principal Investigator to show that the work is not only well designed, but capable of producing field-changing results.
Are incremental advances supported under this award?
The opportunity emphasizes transformative impact and explicitly contrasts this with incremental advances. Proposed studies should aim for fundamental change in what is known or possible in breast cancer prevention, detection, or treatment.
Is preliminary evidence required to apply?
Yes. The proposed research must be grounded in solid evidence. Applications need to be based on sound overall research and be fully supported by preliminary data and/or published reports. The program is not aimed at early, speculative ideas without support.
What does "fully supported by preliminary data and/or published reports" imply in practice?
Based on the announcement summary, proposals should already have a credible foundation demonstrating feasibility or strong scientific rationale. The program favors projects that are ready to be executed at a level capable of producing field-changing results, rather than projects that are still exploratory without supporting evidence.
Can two Principal Investigators apply together?
Yes. The award encourages collaboration through a formal Partnering PI Option. Two Principal Investigators can submit a single, jointly developed application, with one serving as the Initiating PI and the other as the Partnering PI.
How does the Partnering PI Option work in terms of awards and submissions?
Under the Partnering PI Option, the two-PIs structure results in separate awards for each PI while still being a single unified project and application. The Initiating PI and Partnering PI have different submission requirements, but both are expected to contribute meaningfully to the joint project.
Do the Partnering PIs need to be from different disciplines?
Not necessarily. The partners can come from similar or very different disciplines, but they must bring distinct strengths. The application must also explain why collaboration is essential and why the unified approach is stronger than two separate efforts.
Are new collaborations required for the Partnering PI Option?
No. New collaborations are welcomed but not required. The emphasis is on demonstrating a productive, well-justified partnership that strengthens the ability to answer the research question.
What is the expected scale of projects funded by this award?
The opportunity is intended to support projects ranging from small to large scale, as long as the work tackles major scientific or clinical problems in breast cancer and is positioned to deliver significant impact.
What funding instruments are used for this opportunity?
The listing states that grant and cooperative agreement funding instruments were used.
What is the total estimated funding and the expected number of awards?
The estimated total funding was $15,000,000, with an expected five awards.
Is cost sharing or matching required?
No. The opportunity specifies that it did not require cost sharing or matching.
Who was eligible to apply?
Eligibility is listed as unrestricted, meaning it was broadly open to different types of applicant organizations, subject to any additional eligibility clarifications in the full announcement.
Which program and agency administer this award?
This opportunity is part of the CDMRP Breast Cancer Research Program (BCRP) and is run through the Department of the Army via USAMRAA.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 12.420, Military Medical Research and Development.
How was the opportunity categorized?
It was categorized under Science and Technology and other Research and Development.
When was this opportunity posted and when did it close?
The opportunity was posted on February 23, 2012. The original and final closing date listed was August 15, 2012, and the archive date was September 14, 2012.
Who should applicants contact for access issues or questions?
The point of contact listed was the CDMRP Help Desk at 301-682-5507 or help@cdmrp.org.
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