Opportunity Information: Apply for W81XWH 10 BCRP MTA
Apply for W81XWH 10 BCRP MTA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer Multi Team Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Feb 1, 2010 and posted on Jan 29, 2010.
- Applicants must submit their applications by Jun 23, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $23,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Breast Cancer Multi Team Award (BCRP MTA) is a Department of the Army funding opportunity designed to push breast cancer research forward by requiring a tightly integrated, highly collaborative project run by three coordinated research teams. Rather than supporting three loosely connected projects, this mechanism is built around the idea that consistent, intensive teamwork across disciplines can reshape how the research is done, speed up translation into patient impact, and open up new directions where the field may not yet have a clear roadmap. The award is structured to encourage creativity and innovation, and it expects a level of interaction that keeps all teams actively engaged in planning, execution, problem-solving, and decision-making throughout the life of the project.
A central requirement is that the proposed work must revolve around a major breast cancer question that is both high impact and insufficiently addressed to date, especially in areas where established paradigms, standard methods, or technical frameworks may be missing. The program emphasizes broad, disease-level issues with real implications for prevention, prognosis, and risk management, using examples like risk factors or tumor dormancy. In other words, the focus should not be limited to narrow, incremental work such as studying a single pathway or gene in isolation. Importantly, the project must include a clinical research component, and clinical trials may be included, reinforcing the expectation that the overall effort connects basic discovery to patient-oriented investigation.
The collaboration must be organized as three teams, each led by a Principal Investigator, and the PI group must include (1) a basic scientist, (2) a clinician, and (3) a third PI from another relevant discipline such as epidemiology or a similarly appropriate area of expertise. At least two different institutions must be represented among the three PIs, which encourages cross-institutional coordination rather than a single-site effort. The opportunity is explicit that all three PIs should have demonstrated creativity and innovation, and that they are expected to share real intellectual ownership of the project. The application should clearly show that the PIs jointly developed the research plan and management approach, that responsibilities and effort are balanced across teams unless a strong justification is provided, and that the combined membership across the teams brings the right mix of skills needed to answer the overarching research question.
Another defining feature of this award is the required, meaningful integration of breast cancer consumer advocates. Each PI-led team must include one or more consumer advocates who are not simply advisors on the side, but active participants in planning, implementation, and collaboration management. Their involvement is expected to span key functions such as shaping the research question, contributing to study design, helping oversee progress, supporting recruitment where relevant, and participating in evaluation. These interactions must be ongoing and well-integrated rather than limited to occasional attendance at presentations or periodic meetings. The advocates must be lay representatives diagnosed with breast cancer, affiliated with a breast cancer advocacy organization, and acting independently of their employment; they also cannot be employees of any organization applying for the grant. Even though they are considered lay representatives, they are expected to be well trained and familiar with current issues in breast cancer research.
The program also places strong operational demands on how teams work together. Regular in-person multi-team meetings are required at least twice per year, and these meetings must include all three PIs and key members of the teams, including consumer advocates. In addition, the award anticipates frequent remote meetings (for example, weekly) using teleconferencing or web-based tools to share data, track progress toward aims, and coordinate work in real time. The announcement also expects the creation of a shared server or equivalent infrastructure so that presentations and source data are accessible to all team members, reinforcing transparency and continuous collaboration rather than siloed progress reports.
Cross-disciplinary training is not optional under this mechanism. To ensure the collaboration is immersive and genuinely integrative, at least two key members from each research team must spend time working in another collaborating team’s lab or clinical setting. This cross-training can occur as a single extended visit lasting several weeks or as multiple shorter visits, but the intent is hands-on exposure to the other discipline’s methods, constraints, and workflows. Applicants must also present a clear, credible collaboration management plan explaining how the teams will coordinate day to day, resolve problems, make decisions, and keep the effort aligned with milestones. Participating institutions are expected to proactively address intellectual property and materials issues and remove institutional barriers that could limit cooperation.
From an application and accountability standpoint, the proposal should include an organizational chart that clarifies roles, responsibilities, and workflow both within and between labs and clinical settings. The required Statement of Work (SOW) must lay out specific milestones and describe how aims will be staged or integrated to reach those milestones. The announcement stresses that key decision points should be clearly identified, along with how those decisions affect downstream tasks and overall project success, signaling a preference for well-structured project management rather than open-ended exploratory plans.
Administratively, this opportunity was posted under Funding Opportunity Number W81XWH-10-BCRP-MTA and is categorized as a discretionary Science and Technology / R&D program using a cooperative agreement or grant instrument. The program anticipated making about three awards, with an estimated total funding level of $23,000,000 and no cost sharing or matching requirement. Eligibility is listed as unrestricted (open broadly to entity types, subject to any additional eligibility clarifications in the full announcement). The opportunity was posted January 29, 2010, with an original and current closing date of June 23, 2010, and an archive date of July 23, 2010. The sponsoring agency is the Department of the Army through USAMRAA, and the CFDA listing is 12.420 (Military Medical Research and Development). For applicant support, the announcement provides contacts for assistance accessing the announcement and for submission support through the CDMRP help resources.
DoD Breast Cancer Multi Team Award (BCRP MTA) - FAQs
What is the DoD Breast Cancer Multi Team Award (BCRP MTA)?
The Breast Cancer Multi Team Award (MTA) is a Department of the Army funding opportunity under the DoD Breast Cancer Research Program (BCRP). It is designed to advance breast cancer research by supporting a single, tightly integrated project carried out by three coordinated research teams that work together intensively across disciplines.
What is the core purpose of this award mechanism?
The award is built to promote consistent, high-level collaboration rather than three loosely connected projects. It aims to reshape how the research is done, speed translation into patient impact, and open new directions where the field may not yet have established paradigms, standard methods, or technical frameworks.
How many research teams are required?
Three coordinated research teams are required. The project is expected to function as one integrated effort with continuous interaction across all teams.
Who leads each team?
Each team must be led by a Principal Investigator (PI). The three PIs are expected to share real intellectual ownership of the overall project and jointly develop both the research plan and the collaboration/management approach.
What disciplines must be represented among the three PIs?
The PI group must include: (1) a basic scientist, (2) a clinician, and (3) a third PI from another relevant discipline (for example, epidemiology or a similarly appropriate area of expertise).
Are multiple institutions required?
Yes. At least two different institutions must be represented among the three PIs, encouraging cross-institutional coordination rather than a single-site effort.
What kind of research question should the project address?
The work must revolve around a major breast cancer question that is high impact and insufficiently addressed to date, especially in areas where established paradigms or standard methods may be missing. The program emphasizes broad, disease-level issues with real implications for prevention, prognosis, and risk management.
What kinds of topics are explicitly emphasized as examples?
The opportunity gives examples such as risk factors and tumor dormancy to illustrate the kind of broad, disease-level questions it is interested in supporting.
What kinds of projects are discouraged?
The program indicates the focus should not be limited to narrow, incremental work such as studying a single pathway or gene in isolation.
Is a clinical research component required?
Yes. The project must include a clinical research component, reinforcing the expectation that the effort connects basic discovery to patient-oriented investigation.
Are clinical trials allowed under this award?
Yes. Clinical trials may be included.
How is collaboration expected to work in practice?
The award expects consistent, intensive teamwork across disciplines, with all teams actively engaged in planning, execution, problem-solving, and decision-making throughout the project period. The intent is continuous collaboration rather than independent workstreams that only connect at reporting time.
What is required regarding consumer advocate involvement?
Meaningful integration of breast cancer consumer advocates is required. Each PI-led team must include one or more consumer advocates who are active participants in planning, implementation, and collaboration management, not occasional advisors.
What roles can consumer advocates play in the project?
The announcement describes involvement spanning key functions such as shaping the research question, contributing to study design, helping oversee progress, supporting recruitment where relevant, and participating in evaluation.
How often should consumer advocates interact with the teams?
Interactions are expected to be ongoing and well-integrated. The opportunity notes that participation should not be limited to occasional attendance at presentations or periodic meetings.
Who qualifies as a consumer advocate for this award?
Consumer advocates must be lay representatives diagnosed with breast cancer, affiliated with a breast cancer advocacy organization, and acting independently of their employment. Even as lay representatives, they are expected to be well trained and familiar with current issues in breast cancer research.
Are there restrictions on consumer advocates being employees of applicant organizations?
Yes. Consumer advocates cannot be employees of any organization applying for the grant.
What are the required in-person meeting expectations?
Regular in-person multi-team meetings are required at least twice per year. These meetings must include all three PIs and key members of the teams, including consumer advocates.
Are remote meetings expected as well?
Yes. The award anticipates frequent remote meetings (for example, weekly) using teleconferencing or web-based tools to share data, track progress toward aims, and coordinate work in real time.
Is shared collaboration infrastructure required?
Yes. The announcement expects the creation of a shared server or equivalent infrastructure so that presentations and source data are accessible to all team members, supporting transparency and continuous collaboration.
Is cross-disciplinary training required?
Yes. Cross-disciplinary training is required and is described as not optional for this mechanism.
What exactly is required for cross-training?
At least two key members from each research team must spend time working in another collaborating team’s lab or clinical setting. This can be one extended visit lasting several weeks or multiple shorter visits, with the intent being hands-on exposure to the other discipline’s methods, constraints, and workflows.
Is a collaboration management plan required?
Yes. Applicants must present a clear, credible collaboration management plan describing how the teams will coordinate day to day, resolve problems, make decisions, and keep the effort aligned with milestones.
What does the announcement say about intellectual property (IP) and materials issues?
Participating institutions are expected to proactively address intellectual property and materials issues and remove institutional barriers that could limit cooperation.
What application elements are mentioned as required for organization and accountability?
The proposal should include an organizational chart clarifying roles, responsibilities, and workflow within and between labs and clinical settings. A required Statement of Work (SOW) must lay out specific milestones and describe how aims will be staged or integrated to reach those milestones.
What does the Statement of Work (SOW) need to emphasize?
The SOW should identify specific milestones, explain how aims will be staged or integrated to reach those milestones, and clearly identify key decision points, including how decisions affect downstream tasks and overall project success.
What is the Funding Opportunity Number (FON) for this award?
The Funding Opportunity Number is W81XWH-10-BCRP-MTA.
What is the sponsoring agency?
The sponsoring agency is the Department of the Army through USAMRAA.
What is the CFDA listing for this program?
The CFDA listing is 12.420 (Military Medical Research and Development).
What type of funding instrument is used?
The opportunity is categorized as a discretionary Science and Technology / R&D program using a cooperative agreement or grant instrument.
How many awards were anticipated?
The program anticipated making about three awards.
What was the estimated total funding level?
The estimated total funding level was $23,000,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning it is open broadly to entity types, subject to any additional eligibility clarifications in the full announcement.
When was the opportunity posted?
The opportunity was posted on January 29, 2010.
What was the closing date for applications?
The original and current closing date was June 23, 2010.
When was the opportunity archived?
The archive date was July 23, 2010.
Where can applicants get help with accessing the announcement or submitting an application?
The announcement provides contacts for assistance accessing the announcement and for submission support through CDMRP help resources.
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