Opportunity Information: Apply for W81XWH 10 BCRP TVA
Apply for W81XWH 10 BCRP TVA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer Transformative Vision Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Feb 1, 2010 and posted on Jan 29, 2010.
- Applicants must submit their applications by Jun 23, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $9,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Breast Cancer Transformative Vision Award (Funding Opportunity Number W81XWH-10-BCRP-TVA) is a Department of the Army, USAMRAA funding opportunity under the Congressionally Directed Medical Research Programs that is built around one central expectation: applicants must present a bold, clearly stated vision for a fundamentally new approach that could dramatically change the prevention or treatment of breast cancer, and then back that vision with a concrete plan to test it and move it forward as quickly as possible. The emphasis is not on incremental progress or routine extensions of existing work, but on ideas that can credibly shift the field in a major way. Proposals are expected to explain the current state of the art and make a compelling case for how the proposed vision would transform that baseline, whether the anticipated impact is near-term or longer-term, as long as the ultimate effect on breast cancer outcomes is truly transformative.
A defining feature of this mechanism is that it demands both imagination and execution. On the “Vision” side, the application should articulate a new conceptual direction that could significantly alter how breast cancer is prevented or treated. Reviewers are looking for a clear description of what is currently possible, what gap or limitation is holding the field back, and how the applicant’s approach changes the rules rather than simply optimizing existing methods. The vision needs to be ambitious but also grounded in a plausible scientific rationale, showing why this direction could realistically produce a revolutionary impact if successful.
On the “Implementation” side, the opportunity requires a detailed, milestone-driven plan. Applicants must identify critical milestones and describe the innovations and technical solutions that will be used to reach them. This includes laying out what will be built, tested, validated, or translated, and how progress will be measured along the way. The expectation is an exceptional level of innovation and creativity paired with a practical roadmap, including assembling the right multidisciplinary team to execute the work. The Principal Investigator is expected to have demonstrated experience leading large, focused projects, reflecting the scale and complexity implied by a transformative effort that may span basic research through clinical studies, as long as the endpoint aims at a revolutionary change in breast cancer prevention or treatment.
The award is structured in two phases to balance early validation with later-scale execution. Phase I is meant to establish the foundation of the project and test the basic concepts underlying the vision, essentially proving that the core idea is workable and worth expanding. Phase II supports the expansion needed to drive toward accomplishing the vision, allowing the team to build on Phase I results and push toward the intended transformative impact. This phased structure signals that the program values both early feasibility testing and a pathway to broader development, rather than funding a single static research plan from start to finish.
Administratively, this opportunity was posted January 29, 2010, with an original and current closing date of June 23, 2010, and an archive date of July 23, 2010. It is categorized as discretionary funding for science and technology and other research and development, offered as a cooperative agreement grant. The estimated total funding amount was $9,000,000, with an expectation of approximately three awards. The CFDA number listed is 12.420 (Military Medical Research and Development). There is no cost sharing or matching requirement, and eligibility is described as unrestricted, meaning it is broadly open to applicant organizations, subject to any additional eligibility clarifications in the full announcement. For assistance, the announcement provides contact points for program announcement help (cdmrp.pa@amedd.army.mil; 301-619-7079) and eReceipt/CDMRP help desk support (help@cdmrp.org; 301-682-5507).
FAQs: DoD Breast Cancer Transformative Vision Award (W81XWH-10-BCRP-TVA)
What is the DoD Breast Cancer Transformative Vision Award?
The Breast Cancer Transformative Vision Award (Funding Opportunity Number W81XWH-10-BCRP-TVA) is a Department of Defense funding opportunity managed by the Department of the Army, USAMRAA under the Congressionally Directed Medical Research Programs (CDMRP). It is built around a central expectation: applicants must present a bold, clearly stated vision for a fundamentally new approach that could dramatically change the prevention or treatment of breast cancer, and back that vision with a concrete plan to test it and move it forward quickly.
What type of funding mechanism is this opportunity?
This opportunity is offered as a cooperative agreement grant.
What is the primary goal of this award?
The primary goal is to support proposals that can credibly shift the breast cancer field in a major way by introducing a fundamentally new approach to prevention or treatment, rather than producing incremental progress or routine extensions of existing work.
What kinds of projects is the program explicitly trying to avoid funding?
The program emphasizes that it is not focused on incremental progress or routine extensions of existing work. It is intended for ideas that change the rules rather than simply optimize current methods.
What does the program mean by a "transformative vision"?
A transformative vision is a new conceptual direction that could significantly alter how breast cancer is prevented or treated. The application is expected to describe the current state of the art, identify the gap or limitation holding the field back, and explain how the proposed approach would transform that baseline in a major way.
Does the proposed impact need to be immediate?
No. Proposals may target near-term or longer-term impact, as long as the ultimate expected effect on breast cancer outcomes is truly transformative.
What are reviewers looking for on the "Vision" side of the application?
Reviewers are looking for a clear description of what is currently possible, what key limitation or gap exists, and how the proposed approach changes the field rather than making incremental improvements. The vision should be ambitious but grounded in a plausible scientific rationale that explains why it could produce a revolutionary impact if successful.
What are reviewers looking for on the "Implementation" side of the application?
The opportunity requires a detailed, milestone-driven plan. Applicants must identify critical milestones and describe the innovations and technical solutions that will be used to reach them. The plan should spell out what will be built, tested, validated, or translated, and how progress will be measured.
Are milestones required, and what should they include?
Yes. The program expects applicants to identify critical milestones, explain how those milestones will be achieved, and describe how progress will be measured along the way.
What kinds of activities might be included in the implementation plan?
Based on the announcement description, the plan may include building, testing, validating, or translating innovations and technical solutions, with clear measures of progress tied to defined milestones.
Is the award structured in phases?
Yes. The award is structured in two phases (Phase I and Phase II) to balance early validation with later-scale execution.
What is Phase I intended to support?
Phase I is intended to establish the foundation of the project and test the basic concepts underlying the vision. In other words, Phase I is meant to show that the core idea is workable and worth expanding.
What is Phase II intended to support?
Phase II supports the expansion needed to drive toward accomplishing the vision, allowing the team to build on Phase I results and push toward the intended transformative impact.
Does the program fund a single static plan from start to finish?
The phased structure indicates the program values early feasibility testing followed by a pathway to broader development, rather than supporting one static research plan without staged validation and expansion.
What is the expected role or experience level of the Principal Investigator (PI)?
The PI is expected to have demonstrated experience leading large, focused projects, reflecting the scale and complexity implied by a transformative effort.
Is a multidisciplinary team expected?
Yes. The description emphasizes assembling the right multidisciplinary team to execute the work, aligning with the innovation and execution demands of a transformative effort.
What research scope does the program contemplate?
The effort may span basic research through clinical studies, as long as the endpoint aims at a revolutionary change in breast cancer prevention or treatment.
When was this funding opportunity posted?
The opportunity was posted on January 29, 2010.
What was the closing date for applications?
The original and current closing date listed is June 23, 2010.
When was the opportunity archived?
The archive date listed is July 23, 2010.
How much total funding was estimated for this opportunity?
The estimated total funding amount was $9,000,000.
How many awards were expected to be made?
The opportunity expected approximately three awards.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
What is the CFDA number associated with this program?
The CFDA number listed is 12.420 (Military Medical Research and Development).
How is this opportunity categorized?
It is categorized as discretionary funding for science and technology and other research and development.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to applicant organizations, subject to any additional eligibility clarifications in the full announcement.
Which office administers this opportunity?
The opportunity is associated with the Department of the Army, USAMRAA, and is part of the Congressionally Directed Medical Research Programs (CDMRP).
What is the best contact for program announcement questions?
For program announcement help, the listed contact is cdmrp.pa@amedd.army.mil or 301-619-7079.
What is the best contact for eReceipt/CDMRP Help Desk support?
For eReceipt/CDMRP Help Desk support, the listed contact is help@cdmrp.org or 301-682-5507.
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