DoD FY11 Prostate Cancer Population Based Research Award | Apply Online

Opportunity Summary:

The DoD FY11 Prostate Cancer Population Based Research Award (Funding Opportunity Number W81XWH-11-PCRP-PBRA) is a U.S. Army Medical Research and Materiel Command (USAMRAA) grant program under the Congressionally Directed Medical Research Programs (CDMRP) Prostate Cancer Research Program (PCRP). It is designed to support high-impact, population-based prostate cancer research that can meaningfully reduce death and suffering from the disease. This mechanism evolved from the FY09 Population Based Idea Development Award, and the program notes that, up to that point, 51 applications had been received with 3 recommended for funding, emphasizing that the award is competitive and focused on studies with clear potential for major contribution.

The central purpose of the award is to generate information and/or tools that can only be produced by systematically studying a defined patient population at adequate scale. In practical terms, the program is looking for projects where the population perspective is not incidental, but essential: research questions that require large, well-characterized cohorts, strong study design, and the ability to detect meaningful effects with statistical confidence. Because of that, a robust, well-justified statistical plan is a core expectation, and applicants are expected to show that the team includes the necessary statistical expertise and that the statistical approach is integrated into the study from the start rather than treated as an afterthought.

Applicants are strongly encouraged to align their proposals with one of the FY11 PCRP overarching challenges. While projects across the spectrum from basic to clinical research are welcome, proposals that do not directly address an overarching challenge must clearly justify how they still meet a critical unmet need in prostate cancer research and/or patient care. The program supports a range of population-based designs, including retrospective studies, prospective studies, case-control studies, cohort studies, and other systematic approaches. It also explicitly allows use of biospecimens and data from established retrospective databases, as long as the planned sample size is sufficient to achieve statistical significance and the hypothesis is well developed, conceptually sound, and specific to prostate cancer.

A key review and feasibility issue for this mechanism is access to the population. Applicants are expected to provide documentation showing they can access and recruit the appropriate study population(s) or obtain patient samples in the numbers needed to power the analysis. This emphasis signals that feasibility, recruitment capacity, data availability, and sample size justification are likely to weigh heavily in evaluations, alongside the scientific merit and potential impact.

Topic areas highlighted as a good fit include biomarkers, predictors of response to therapy, disease aggressiveness, epidemiology and public health, genomics (germline or somatic), health disparities, molecular genetics, and risk prediction. These areas reflect an interest in identifying who is at risk, who will progress, who will respond to treatment, and how outcomes differ across populations, with the broader aim of translating population-level insights into better prevention, diagnosis, and care strategies.

Human subjects research is allowed, but the award does not support clinical trials. The announcement draws a clear boundary: a clinical trial is defined as prospective accrual of human subjects in which an intervention (such as a drug, device, biologic, surgery, rehabilitation, or behavioral intervention) is tested for outcomes related to safety, effectiveness, or efficacy. However, correlative studies are permitted, including studies that use populations from existing clinical trials, meaning applicants can analyze clinical trial samples or datasets to answer new population-based questions as long as they are not running a new interventional trial under this award. Investigators intending to conduct a clinical trial are directed instead to the FY11 PCRP Clinical Trial Award. Additional guidance on clinical research and human subjects expectations is referenced through the CDMRP Human Subject Resource Document.

Administratively, this opportunity is listed as a discretionary funding program using a cooperative agreement grant instrument, categorized under science and technology and other research and development, with no cost sharing or matching requirement. The estimated total funding is $2.9 million, with an expectation of making about three awards. Eligibility is described as unrestricted, open to any type of entity, subject to any clarifications that may appear in the full announcement. Key dates include a posted/creation date of April 21, 2011, and an application closing date of June 8, 2011 (with an archive date of July 8, 2011). For access issues or assistance, the CDMRP Help Desk contact number is 301-682-5507.

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