Opportunity Information: Apply for W81XWH 12 NFRP EHDA
Apply for W81XWH 12 NFRP EHDA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD FY12 Neurofibromatosis Exploration Hypothesis Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Mar 22, 2012 and posted on Mar 22, 2012.
- Applicants must submit their applications by May 31, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $480,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DOD FY12 Neurofibromatosis Exploration Hypothesis Development Award (Funding Opportunity Number W81XWH 12 NFRP EHDA) was a U.S. Army Medical Research acquisition run through USAMRAA under the Congressionally Directed Medical Research Programs (CDMRP). It targeted early-stage neurofibromatosis (NF) research ideas that are intentionally bold and uncertain, with the goal of seeding concepts that could later mature into full hypotheses and larger, more definitive studies. The core purpose was to give researchers room to test unconventional directions, especially when the science is too new, speculative, or unproven to fit traditional funding mechanisms that demand extensive preliminary data.
The program was built around the idea of "high risk, high gain" exploration. Applicants were expected to propose an innovative question or concept and generate initial principles or proof-of-concept type results. Rather than requiring a fully developed hypothesis supported by strong preliminary evidence, the award emphasized discovery and early validation: producing data that could establish scientific rationale for forming a new hypothesis. In practical terms, it was meant to fund the kind of exploratory experiments that help determine whether a novel mechanism, pathway, model, technology, biomarker approach, or therapeutic strategy in NF is worth deeper investment. A distinctive feature of the opportunity was its explicit encouragement of pursuing serendipitous observations, meaning investigators could follow up on unexpected findings that might open a new line of NF research but would otherwise be difficult to support through conventional grants.
From an administrative and funding standpoint, this was a discretionary research and development opportunity in the Science and Technology/other R&D category, offered through either grants or cooperative agreements. The government anticipated making about three awards, with an estimated total program funding level of $480,000, and it did not require cost sharing or matching funds. Eligibility was listed as "unrestricted," indicating that applications were open broadly to many entity types (such as academic institutions, nonprofits, small businesses, or other organizations), subject to any specific clarifications that would have been included in the full announcement.
Key dates reflect that this was a FY12 cycle opportunity: it was posted and created on March 22, 2012, with an original and final closing date of May 31, 2012, and it was archived on June 30, 2012. The listing also referenced CFDA 12.420 (Military Medical Research and Development), which is the federal assistance catalog entry tied to this type of DOD medical R&D support. For logistical or technical issues accessing the full announcement, applicants were directed to the CDMRP help resources (PA HELP and eReceipt HELP) at 301-682-5507 and help@cdmrp.org, reflecting the typical CDMRP electronic submission and support process.
Overall, the award functioned as a catalyst for new NF research directions: it prioritized creativity, early experimental traction, and the generation of just enough evidence to justify a follow-on hypothesis and future funding, rather than rewarding only projects that were already well established.
FAQs: DOD FY12 Neurofibromatosis (NF) Exploration Hypothesis Development Award (W81XWH 12 NFRP EHDA)
What is the DOD FY12 Neurofibromatosis Exploration Hypothesis Development Award?
It was a U.S. Department of Defense (DOD) funding opportunity under the Congressionally Directed Medical Research Programs (CDMRP), run as a U.S. Army Medical Research acquisition through USAMRAA. The award supported early-stage neurofibromatosis (NF) research ideas that were intentionally bold and uncertain, with the goal of seeding concepts that could later mature into full hypotheses and larger, more definitive studies.
What is the funding opportunity number for this program?
The funding opportunity number was W81XWH 12 NFRP EHDA.
What kinds of projects was this award designed to fund?
The award was designed for exploratory, high risk/high gain NF research. It emphasized testing innovative questions or concepts and generating initial principles or proof-of-concept type results that could establish scientific rationale for forming a new hypothesis.
How does this award differ from traditional research grants?
Unlike traditional funding mechanisms that often require extensive preliminary data and a fully developed hypothesis, this opportunity emphasized discovery and early validation. It aimed to fund exploratory experiments that help determine whether a novel direction in NF research is worth deeper investment.
Was a fully developed hypothesis required to apply?
No. The opportunity emphasized early-stage exploration and generating enough evidence to support the formation of a new hypothesis, rather than requiring a fully developed hypothesis backed by strong preliminary evidence.
What does "high risk, high gain" mean in the context of this opportunity?
It means the program intentionally supported ideas that were bold, uncertain, speculative, or unproven. The expectation was that some ideas might not work, but successful projects could open meaningful new directions for NF research.
What types of research directions were explicitly within scope?
Based on the description, the award could support exploratory work on novel mechanisms, pathways, models, technologies, biomarker approaches, or therapeutic strategies related to neurofibromatosis, as long as the work was early-stage and aimed at establishing initial feasibility or rationale.
Did the program encourage following up on unexpected results?
Yes. A distinctive feature was explicit encouragement of pursuing serendipitous observations, allowing investigators to follow up on unexpected findings that might open a new line of NF research.
What was the overall purpose of the award?
The purpose was to provide room for researchers to test unconventional directions and generate early evidence that could justify a follow-on hypothesis and future funding, rather than rewarding only projects that were already well established.
Who administered and ran this opportunity?
It was a U.S. Army Medical Research acquisition run through USAMRAA under the CDMRP.
What funding instruments were used (grant vs cooperative agreement)?
The opportunity was offered through either grants or cooperative agreements.
What category of federal funding was this listed under?
It was listed as a discretionary research and development opportunity in the Science and Technology/other R&D category.
How many awards did the government anticipate making?
The government anticipated making about three awards.
What was the estimated total funding available for the program?
The estimated total program funding level was $480,000.
Was cost sharing or matching funds required?
No. The opportunity did not require cost sharing or matching funds.
Who was eligible to apply?
Eligibility was listed as "unrestricted," meaning applications were open broadly to many entity types (such as academic institutions, nonprofits, small businesses, or other organizations), subject to any specific clarifications that would have been included in the full announcement.
When was this funding opportunity posted?
It was posted (and created) on March 22, 2012.
What was the application deadline for this opportunity?
The original and final closing date was May 31, 2012.
Is this opportunity still open?
No. It was an FY12 cycle opportunity. It was archived on June 30, 2012, and the closing date was May 31, 2012.
What CFDA number was associated with this opportunity?
The listing referenced CFDA 12.420, Military Medical Research and Development.
What kind of results was the award intended to produce?
The award was intended to produce initial principles or proof-of-concept type results that could establish scientific rationale and help determine whether a new NF research direction should advance into larger, more definitive studies.
What should applicants do if they had technical or logistical issues accessing the full announcement?
Applicants were directed to CDMRP help resources (PA HELP and eReceipt HELP) at 301-682-5507 and help@cdmrp.org.
What submission/support process was referenced?
The description referenced typical CDMRP electronic submission and support processes, including PA HELP and eReceipt HELP for assistance.
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