Opportunity Information: Apply for W81XWH 12 NFRP NIA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD FY12 Neurofibromatosis New Investigator Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Mar 22, 2012 and posted on Mar 22, 2012.
  • Applicants must submit their applications by May 31, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,920,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:

The DOD FY12 Neurofibromatosis (NF) New Investigator Award (Funding Opportunity Number W81XWH-12-NFRP-NIA) is a competitive research funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Department of the Army. It sits within the Congressionally Directed Medical Research Programs (CDMRP) umbrella and is listed under CFDA 12.420 (Military Medical Research and Development). The program is designed to expand and strengthen the neurofibromatosis research workforce by helping investigators build independence and establish a sustained research direction in NF.

The main purpose of this award is career and field development: it supports either (1) promising investigators who are already operating independently and need support to further develop their NF-focused research program, or (2) established investigators from other areas who want to transition into neurofibromatosis research. Prior experience working specifically in NF is permitted but not mandatory, which makes the mechanism accessible to researchers coming from related disciplines (for example, cancer biology, neuroscience, genetics, dermatology, tumor microenvironment research, imaging, or drug development) who can bring fresh approaches into NF. At the same time, the announcement signals that applicants with limited NF background are strongly encouraged to include a collaborator who already has NF expertise, which is a practical way to ensure scientific and clinical relevance, appropriate models and endpoints, and credibility within the NF community.

A key requirement is that applications must include preliminary data that is directly relevant to neurofibromatosis and to the proposed project. In practice, this means the award is not intended for purely speculative ideas without supporting evidence; instead, it favors projects where the investigator can show early feasibility, proof-of-concept results, or compelling pilot findings that justify further investment. The emphasis on NF-relevant preliminary data also suggests the program expects applicants to demonstrate a real connection between their approach and NF biology or NF patient needs, rather than a generic research plan that could apply to any disease area.

From an administrative and funding standpoint, the opportunity is categorized as discretionary and supports projects through either grants or cooperative agreements (as indicated by the listed funding instrument types). The total estimated funding amount for this specific cycle was $1,920,000, with an expectation of making about three awards, implying a relatively selective competition. There is no cost-sharing or matching requirement, which reduces barriers for applicants and institutions by not requiring them to contribute additional funds as a condition of receiving the award.

Eligibility is described as unrestricted, meaning it is broadly open to a wide range of applicant organizations and entity types, subject to any clarifications that would have appeared in the full announcement under the eligibility details section. The posting date was March 22, 2012, and the application deadline for that cycle was May 31, 2012, with the opportunity later archived on June 30, 2012. For applicant support and technical issues accessing the full announcement, the listed point of contact was the CDMRP Help Desk (help@cdmrp.org, 301-682-5507), which is typical for CDMRP-managed opportunities that rely on their electronic submission and receipt systems.

Overall, this funding mechanism is best understood as an on-ramp or accelerator for investigators who can show early, NF-specific traction and who are positioned to become long-term contributors to the neurofibromatosis research landscape. It rewards both scientific promise and a credible plan to execute NF-relevant work, particularly when supported by appropriate collaboration and preliminary evidence.

FAQs: DOD FY12 Neurofibromatosis (NF) New Investigator Award (W81XWH-12-NFRP-NIA)

What is this funding opportunity?

The DOD FY12 Neurofibromatosis (NF) New Investigator Award is a competitive research funding opportunity administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Department of the Army. It is part of the Congressionally Directed Medical Research Programs (CDMRP) and is listed under CFDA 12.420 (Military Medical Research and Development).

What is the main goal of the New Investigator Award?

The award is designed to expand and strengthen the neurofibromatosis research workforce by helping investigators build independence and establish a sustained research direction focused on neurofibromatosis (NF). The emphasis is career and field development, not just a single standalone project.

Who is this award intended to support?

The program supports two main groups: (1) promising investigators who are already operating independently and need support to further develop their NF-focused research program, and (2) established investigators from other research areas who want to transition into neurofibromatosis research.

Do applicants need prior experience specifically in neurofibromatosis research?

No. Prior NF experience is allowed but not required. The opportunity is designed to be accessible to investigators coming from related disciplines who can bring fresh approaches into NF research.

What kinds of non-NF backgrounds might be a fit for this mechanism?

The announcement highlights that researchers from areas such as cancer biology, neuroscience, genetics, dermatology, tumor microenvironment research, imaging, or drug development may be well positioned to transition into NF research and contribute new methods or perspectives.

If an applicant has limited NF background, is collaboration expected?

Yes. While not stated as mandatory, applicants with limited NF background are strongly encouraged to include a collaborator who already has NF expertise. This is presented as a practical way to ensure scientific and clinical relevance, appropriate models and endpoints, and credibility within the NF community.

Is preliminary data required?

Yes. A key requirement is that applications must include preliminary data that is directly relevant to neurofibromatosis and to the proposed project.

What does it mean that preliminary data must be "directly relevant to NF"?

Based on the description, this means the project should not be purely speculative. Applicants are expected to show early feasibility, proof-of-concept results, or compelling pilot findings that connect the proposed approach to NF biology and/or NF patient needs, rather than presenting a generic plan that could apply to any disease area.

What types of funding instruments are used for this opportunity?

The opportunity supports projects through grants or cooperative agreements, as indicated by the listed funding instrument types.

Is this a discretionary funding opportunity?

Yes. The opportunity is categorized as discretionary.

How much total funding was estimated for this FY12 cycle?

The total estimated funding amount for this cycle was $1,920,000.

How many awards were expected to be made?

The program expected to make about three awards, which suggests a relatively selective competition.

Is cost-sharing or matching required?

No. The opportunity states there is no cost-sharing or matching requirement.

Who is eligible to apply?

Eligibility is described as unrestricted, meaning it is broadly open to a wide range of applicant organizations and entity types, subject to any further details that would have been provided in the full announcement's eligibility section.

What is the Funding Opportunity Number (FON) for this award?

The Funding Opportunity Number is W81XWH-12-NFRP-NIA.

When was this opportunity posted and when was it due?

The posting date was March 22, 2012, and the application deadline for that cycle was May 31, 2012.

Is this opportunity still open?

No. The opportunity was later archived on June 30, 2012.

Where does this award sit within the federal funding landscape?

It is administered through USAMRAA under the Department of the Army, sits within CDMRP, and is listed under CFDA 12.420 (Military Medical Research and Development).

Who should be contacted for help with applicant support or technical issues?

The listed point of contact for applicant support and technical issues accessing the full announcement is the CDMRP Help Desk: help@cdmrp.org or 301-682-5507.

How should applicants think about the "new investigator" focus in practical terms?

Based on the description, the mechanism functions as an on-ramp or accelerator for investigators who can show early NF-specific traction and who are positioned to become long-term contributors to the NF research landscape, including those building independence in NF or transitioning into NF from another field.

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