DOD FY12 Tuberous Sclerosis Complex Exploration Hypothesis Development Award | Apply Online

Opportunity Summary:

The DOD FY12 Tuberous Sclerosis Complex (TSC) Exploration Hypothesis Development Award was a competitive research funding opportunity run through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), under the Congressionally Directed Medical Research Programs (CDMRP) umbrella. Its purpose was to spark early-stage, high-risk, high-reward studies in the TSC field, with an emphasis on ideas that could be genuinely novel or even potentially groundbreaking. Rather than funding large, fully mature projects, the award was structured to help researchers take the first serious step toward testing an unconventional concept, exploring an unexpected result, or building the early evidence needed to justify a brand-new hypothesis.

The central goal of the program was exploration and hypothesis formation. Proposed work was expected to establish initial scientific principles around an innovative question or concept and to generate results that could serve as a rationale for developing a new hypothesis (or substantially reshaping existing thinking). A key theme was flexibility: the award explicitly aimed to give investigators room to follow up on serendipitous observations, meaning surprising or unplanned findings that might open an important new direction but would be difficult to pursue under more conservative funding mechanisms.

Preliminary data were encouraged but not required, which signaled that the program was intentionally designed to lower the barrier for bold ideas that might not yet have extensive supporting evidence. In practice, this type of mechanism typically favors proposals that clearly explain why the idea is novel and important, what initial experiments or analyses will be done to test feasibility, and how the outcomes will position the research for a stronger, more definitive follow-on hypothesis and future funding.

Administratively, the opportunity was posted on March 22, 2012, and had an application deadline of May 31, 2012, with an archive date of June 30, 2012. It was offered as either a cooperative agreement or a grant under the broad category of science and technology and other research and development. The program anticipated making about three awards, with an estimated total funding level of $480,000. There was no cost-sharing or matching requirement, which meant applicants were not expected to contribute non-federal funds as a condition of receiving the award.

Eligibility was listed as unrestricted, meaning it was broadly open to various types of entities, subject to any additional clarifications in the full announcement. The listing also included the CFDA number 12.420 (Military Medical Research and Development), which is the federal catalog identifier associated with the broader funding stream supporting military medical research and related development efforts.

For support, the announcement directed applicants who had trouble accessing the full materials to contact the CDMRP Help Desk (PA HELP and eReceipt HELP) at 301-682-5507 or help@cdmrp.org. Overall, the award was aimed at accelerating creative, early investigations in tuberous sclerosis complex research by providing a relatively accessible funding path for innovative, potentially transformative ideas that were not yet ready for large-scale validation.

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