Opportunity Information: Apply for W81XWH 13 NFRP EHDA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Exploration Hypothesis Development Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on May 3, 2013 and posted on May 3, 2013.
  • Applicants must submit their applications by Jul 11, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $640,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 4 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:

The DoD Neurofibromatosis (NF) Exploration Hypothesis Development Award (EHDA) is a FY2013 funding opportunity run through the Department of the Army (USAMRAA) under the Congressionally Directed Medical Research Programs framework. It sits within the Neurofibromatosis Research Program (NFRP), which has an overall vision of decreasing the clinical impact of neurofibromatosis. In practical terms, the program is looking to push the field forward by supporting innovative and high impact studies, encouraging multidisciplinary and multi-institutional collaboration, bringing in new perspectives, helping develop the next generation of NF researchers, and strengthening translational and clinical work that can move promising ideas from the lab toward patient care. The program also emphasizes maintaining a balanced research portfolio across NF1, NF2, and schwannomatosis rather than focusing on only one subtype.

This particular award mechanism is geared toward early-stage exploration of bold ideas. The EHDA is intended for high risk, high gain, potentially groundbreaking concepts that may not yet have the amount of evidence typically expected for more mature grants. The core expectation is that the project will generate initial findings or “first principles” that can justify a new hypothesis or open up a new research direction. A distinctive feature is that it explicitly creates room for investigators to chase compelling, unexpected leads, including serendipitous observations, rather than only tightly scripted extensions of prior work. Preliminary data and published support are encouraged because they can strengthen the application, but they are not required, which signals that novelty and potential impact are central evaluation themes. At the same time, the Principal Investigator is expected to clearly explain what makes the idea innovative and why the concept is truly novel in the NF landscape.

For FY2013, the NFRP strongly encouraged applications that align with specific Areas of Emphasis reflecting pressing needs in the NF community. These priorities include cognitive and social dysfunction associated with NF, drug discovery efforts aimed at NF treatments, and understanding the heterogeneity of neurofibromas and other NF-related tumors using modern approaches such as genomics, epigenetics, systems biology, and similar methods. Additional emphasis areas include studying how NF manifests after adolescence (recognizing that patient needs evolve across the lifespan), developing novel disease markers including imaging-based and proteomics-based biomarkers, and addressing pain in the context of NF. While the broader program supports work across the full spectrum of NF conditions, applicants were clearly nudged to connect their exploratory concept to one or more of these targeted gaps.

Administratively, the opportunity was posted May 3, 2013, with an application deadline of July 11, 2013, and an archive date of August 10, 2013. The funding opportunity number is W81XWH-13-NFRP-EHDA, and it was offered as either a grant or cooperative agreement under the Science and Technology and other Research and Development activity category. The total estimated funding was $640,000 with an expectation of making about four awards, suggesting relatively limited, competitive funding intended to seed a small number of especially promising exploratory projects. There was no cost sharing or matching requirement. Eligibility was described as unrestricted (open to any entity type), subject to any clarifications in the full announcement. The CFDA listing associated with this program is 12.420 (Military Medical Research and Development). For applicants needing access support or assistance with the announcement, the listed point of contact was the CDMRP Help Desk at 301-682-5507.

FAQs: DoD Neurofibromatosis (NF) Exploration Hypothesis Development Award (EHDA) - FY2013

What is the DoD Neurofibromatosis (NF) Exploration Hypothesis Development Award (EHDA)?

The EHDA is a FY2013 funding opportunity within the Department of Defense Neurofibromatosis Research Program (NFRP), administered through the Department of the Army (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP). It is designed to support early-stage, exploratory research in neurofibromatosis (NF).

What is the main purpose of the EHDA mechanism?

This award mechanism is geared toward early exploration of bold ideas and is intended to generate initial findings or "first principles" that can justify a new hypothesis or open a new research direction in NF.

What types of projects does the EHDA aim to fund?

The EHDA targets high risk, high gain, potentially groundbreaking concepts. It is specifically structured to allow researchers to pursue innovative ideas that may not yet have the level of supporting evidence typically expected for more mature grant mechanisms.

Is preliminary data required to apply?

No. Preliminary data and published support are encouraged because they can strengthen an application, but they are not required. Novelty and potential impact are central themes of this opportunity.

Does the EHDA allow pursuit of unexpected or serendipitous findings?

Yes. A distinctive feature of this mechanism is that it explicitly creates room to chase compelling, unexpected leads, including serendipitous observations, rather than only proposing tightly scripted extensions of prior work.

What does the program expect from the Principal Investigator regarding innovation?

The Principal Investigator is expected to clearly explain what makes the idea innovative and why the concept is truly novel within the NF landscape.

Which neurofibromatosis conditions are within the scope of the broader NFRP?

The NFRP emphasizes maintaining a balanced research portfolio across NF1, NF2, and schwannomatosis rather than focusing on only one subtype.

What is the overall vision of the Neurofibromatosis Research Program (NFRP)?

The NFRP has an overall vision of decreasing the clinical impact of neurofibromatosis. It aims to push the field forward through innovative and high-impact studies and by strengthening translational and clinical work that can move promising ideas toward patient care.

Does the program encourage collaboration?

Yes. The program encourages multidisciplinary and multi-institutional collaboration, bringing in new perspectives, helping develop the next generation of NF researchers, and strengthening translational and clinical research.

What were the FY2013 Areas of Emphasis that the NFRP strongly encouraged?

For FY2013, the NFRP strongly encouraged applications aligned with these Areas of Emphasis:

  • Cognitive and social dysfunction associated with NF
  • Drug discovery efforts aimed at NF treatments
  • Understanding heterogeneity of neurofibromas and other NF-related tumors using modern approaches (e.g., genomics, epigenetics, systems biology, and similar methods)
  • How NF manifests after adolescence (recognizing evolving needs across the lifespan)
  • Novel disease markers, including imaging-based biomarkers and proteomics-based biomarkers
  • Pain in the context of NF

Do applications need to align with an Area of Emphasis?

The FY2013 NFRP strongly encouraged alignment with the listed Areas of Emphasis, and applicants were clearly nudged to connect their exploratory concept to one or more targeted gaps.

What kind of research approaches were highlighted for tumor heterogeneity studies?

The opportunity highlighted modern approaches such as genomics, epigenetics, systems biology, and similar methods for understanding heterogeneity in neurofibromas and other NF-related tumors.

What was the funding opportunity number for this award?

The funding opportunity number was W81XWH-13-NFRP-EHDA.

Which agency administered this opportunity?

The opportunity was run through the Department of the Army (USAMRAA) under the CDMRP framework.

What was the activity category for this opportunity?

The activity category was Science and Technology and other Research and Development.

What funding instrument types were offered?

The opportunity was offered as either a grant or a cooperative agreement.

How much total funding was estimated for FY2013?

The total estimated funding was $640,000.

How many awards were expected to be made?

The program expected to make about four awards, indicating a limited and competitive funding pool intended to seed a small number of especially promising exploratory projects.

Was there a cost sharing or matching requirement?

No. There was no cost sharing or matching requirement.

Who was eligible to apply?

Eligibility was described as unrestricted (open to any entity type), subject to any clarifications in the full announcement.

What is the CFDA number associated with this program?

The CFDA listing associated with this program is 12.420 (Military Medical Research and Development).

When was the opportunity posted?

The opportunity was posted on May 3, 2013.

What was the application deadline?

The application deadline was July 11, 2013.

When was the archive date?

The archive date was August 10, 2013.

Who should applicants contact for help with access or assistance?

Applicants needing access support or assistance with the announcement were directed to the CDMRP Help Desk at 301-682-5507.

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